The Laboratory of Jack Dixon

RECENT PUBLICATIONS

Mitchell, D.A.; Lee, S.W.; Pence, M.A.; Markley, A.M.; Limm, J.D.; Nizet, V.; Dixon, J.E. (2009)
Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S
J. Biol. Chem. In Press

Rardin MJ, Wiley SE, Murphy AN, Pagliarini DJ, Dixon JE. (2008)
Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane.
J Biol Chem. May 30;283(22):15440-50

Worby CA, Gentry MS, Dixon JE. (2008)
Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).
J Biol Chem Feb 15;283(7):4069-76.

Lee SW and Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE. (2008)
Discovery of a Widely Distributed Toxin Biosynthetic Gene Cluster
Proc. Natl. Acad. Sci. USA, 105: 5879-5884

Alto NM, Dixon JE. (2008)
Analysis of Rho-GTPase mimicry by a family of bacterial type III effector proteins.
Methods Enzymol. 439:131-43.

Robinson FL, Niesman IR, Beiswenger KK, Dixon JE. (2008)
Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot-Marie-Tooth 4B2-like peripheral neuropathy in mice.
Proc Natl Acad Sci U S A. 105:4916-4921.

Mattoo S, Alto NM, Dixon JE. (2008)
Subversion of myosin function by E. coli.
Dev. Cell. Jan;14(1):8-10.

Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. (2007)
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.
J Cell Biol. Sep 24;178(7):1265-78.

Mattoo S, Lee YM, Dixon JE. (2007)
Interactions of bacterial effectors proteins with host proteins.
Current Opinion in Immunology. Aug;19(4):392-401.

Wiley SE, Paddock ML, Abresch EC, Gross L, van der Geer P, Nechushtai R, Murphy AN, Jennings PA, Dixon JE. (2007) The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.
J. Biol. Chem. Aug 17;282(33):23745-9.

Gentry MS, Dowen RH 3rd, Worby CA, Mattoo S, Ecker JR, Dixon JE. (2007)
The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease.
J Cell Biol. 2007 Jul 30;178(3):477-88.

Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. (2007)
Identification of a molecular target for the Yersinia protein kinase A.
Mol Cell. 2007 May 25;26(4):465-77.

Kim Y, Gentry MS, Harris TE, Wiley SE, Lawrence JC Jr, Dixon JE. (2007)
A conserved phosphatase cascade that regulates nuclear membrane biogenesis.
Proc Natl Acad Sci U S A. Apr 17;104(16):6596-601

Wiley SE, Murphy AN, Ross SA, van der Geer P, Dixon JE. (2007)
MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.
Proc Natl Acad Sci U S A. Mar 27;104(13):5318-23.

Robinson FL, Dixon JE. (2006)
Myotubularin phosphatases: policing 3-phosphoinositides.
Trends Cell Biol. Aug;16(8):403-12.

Worby, C.A., JE Dixon. (2006)
Bacteria Seize Control by Acetylating Host Proteins.
Science, 312: 1150-51.

D.J. Pagliarini, JE Dixon. (2006)
Mitochondrial modulation of myotubularin phosphatases.
Trends Biochem. Sci. 31: 26-34

M.J. Begley, G.S. Taylor, M.A. Brock, P. Ghosh, V.L. Woods, JE Dixon. (2006)
Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.
Proc. Natl. Acad. Sci. USA. 103: 927-32

N.M. Alto, F. Shao, C.S. Lazar, R.L. Brost, G. Chua, S. Mattoo, P. Ghosh, T.R. Hughes, C. Boone, JE Dixon. (2006)
Identification of a Bacterial Type III Effector Family with Novel G-protein Mimicry Functions.
Cell 124: 133-145

C. A. Worby, C. A., J. E. Dixon. (2005)
Phosphoinositide Phosphatases: Emerging Roles As Voltage Sensors?
Mol. Interv. 5: 274-7

F. L. Robinson, J. E. Dixon. (2005)
The Phosphoinositide 3-Phosphatase MTMR2 Associates with MTMR13, a Novel Membrane-Assoicated Pseudophosphatase also Mutated in Type 4B Charcot-Marie-Tooth Disease.
J. Biol. Chem. 280: 31699-707

M. S. Gentry, C. A. Worby, J. E. Dixon. (2005)
Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin.
Proc. Natl. Acad. Sci. USA. 102: 8501-6

D. J. Pagliarini, S. E. Wiley, M. E. Kimple, J. R. Dixon, P. Kelly, P. J. Casey, J. E. Dixon. (2005)
Involvement of a Mitochondrial Phosphatase in the Regulation of ATP Production and Insulin Secretion in Pancreatic Beta Cells.
Molecular Cell 19: 197-207

D. J. Pagliarini, C. A. Worby, JE Dixon. (2004)
A PTEN-like Phosphatase with a Novel Substrate Specificity.
J. Biol. Chem. 279: 38590-6

A. Alonson, J. Sasin, N. Bottini, I. Friedberg, A. Osterman, A. Godzik, T. Hunter, J. E. Dixon, T. Mustelin. (2004)
Protein Tyrosine Phosphatases in the Human Genome.
Cell 117: 699-711

M. Zhu, F. Shao, R.W. Innes, J. E. Dixon, Z. Xu. (2004)
The Crystal Structure of Pseudomonas Avirulence Protein AvrPphB; a Papain-like Fold with a Distinct Substrate-binding Site
Proc. Natl. Acad. Sci, USA, 101: 302-7

M. Begley, G.S. Taylor, S-A Kim, D.M. Veine, J. E. Dixon, J.A.Stuckey (2003)
Crystal Structure of a Phosphoinositide Phosphatase, MTMR2: Insights into Myotubular Myopathy and Charcot-Marie-Tooth Syndrome
Mol. Cell, 12: 1391-02

F. Shao, G. Golstein, J. Ade, M. Stoutemyer, J. E. Dixon, R. W. Innes. (2003)
Cleavage of Arabidopsis PBS1 by a Bacterial Type III Effector.
Science, 301: 1230-33

Das S, Dixon JE, Cho W. (2003)
Membrane-binding and activation mechanism of PTEN.
Proc Natl Acad Sci U S A. 100:7491-6.

Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE. (2003)
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase.
Proc Natl Acad Sci U S A. 100:4492-7.

Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE. (2003)
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.
Proc Natl Acad Sci U S A. 100: 904-9.

Wishart MJ, Dixon JE (2002)
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.
Trends Cell Biol. 12: 579-85.

Worby CA, Dixon JE. (2002)
Sorting out the cellular functions of sorting nexins
Nat Rev Mol Cell Biol. 3: 919-31.

Shao F.,Merritt F.M., Bao Z., Innes R.W., Dixon JE (2002)
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis
Cell 109: 575-588

Hinnebusch B.J., Rudolph A.E., Cherepanov P., Dixon JE, Schwan T.G., Forsberg A. (2002)
Role of Yersinia murine toxin in survival of Yersinia pestis in the midgut of the flea vector
Science 296(5568): 733-735

Juris S.J., Shao F., Dixon JE (2002)
Yersinia effectors target mammalian signalling pathways Cell Microbiol 4(4):201-211

Worby, C.A., Simonson-Leff, N., Clemens, J.C., Huddler, D.P. Jr., Muda, M., Dixon, JE (2002)
DAck Targets its Substrate, the Sorting Nexin, DSH3PX1, to a Protein Complex Involved in Axonal Guidance
J Biol Chem 277(11):9422-9428

Wishart, M.J., Dixon, JE (2002)
The Archetype STYX/Dead-Phosphatase Complexes with a Spermatid mRNA Binding Protein and is Essential for Normal Sperm Production
Proc Natl Acad Sci USA 99(4):2112-2117

Kim, S-A., Taylor, G.S., Torgersen, M., Dixon, JE (2002)
Myotubularin and MTMR2: Phosphatidylinositol 3-Phosphatases Mutated in Myotubular Myopathy and Type 4B Charcot-Marie-Tooth Disease
J Biol Chem 277(6):4526-4531

Wang, J., Stuckey, J.A., Wishart, M.J., Dixon, JE (2002)
A Unique Carbohydrate Binding Domain Targets the Lafora Disease Phosphatase to Glycogen
J Biol Chem 277(4):2377-2380

Worby, C.A., Simonson-Leff, N., Dixon, JE (2001)
RNA Interference of Gene Expression (RNAi) in Cultured Drosophila Cells.
Sci STKE (95):PL1

Worby, C.A, Simonson-Leff, N., Clemens, J.C., Kruger, R.P., Muda, M., Dixon, JE (2001)
The Sorting Nexin, DSH3PX1, Connects the Axonal Guidance Receptor, Dscam, to the Actin Cytoskeleton
J Biol Chem 276(45):41782-41789

Wishart, M.J., Taylor, G.S., Dixon, JE (2001)
Phoxy lipids: revealing PX domains as phosphoinositide binding modules
Cell 105:817-820

Gustin, J.A., Maehama, T., Dixon, JE, Donner, D.B. (2001)
The PTEN Tumor Suppressor Protein Inhibits TNF Induced NF-B Activity
J Biol Chem 276(29):27740-27744

Maehama, T., Taylor, G.S., Dixon, JE (2001)
PTEN and Myotubularin: Novel Phosphoinositide Phosphatases
Ann Rev Biochem 70:247-279

Wishart, M.J., Taylor, G.S., Slama, J.T., and Dixon, JE (2001)
PTEN and Myotubularin Phosphoinositide Phosphatases: Bringing Bioinformatics to the Lab Bench
Curr Opin Cell Biol 13(2):172-181

PREVIOUS NOTABLE PUBLICATIONS

Lee, J-O., Yang, H., Georgescu, M-M., Di Cristofano, A., Maehama, T., Shi, Y., Dixon, JE, Pandolfi, P.P., Pavletich, N.P. (1999)
Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide
Phosphatase Activity and Membrane Association.
Cell 99: 323-334

Orth, K., Palmer, L.E, Bao, Z.Q., Stewart, S., Rudolph, A., Bliska, J.B., Dixon, JE (1999)
Inhibition of the mitogen-activated Protein Kinase Kinase Superfamily by a Yersinia deffector
Science 285:1920-1923

Rudolph, A.E., Stuckey, J., Zhao, Y., Matthews, H.R., Patton, W.A., Moss, J., Dixon, JE (1999)
Expression, Characterization, and Mutagenesis of the Yersinia pestis
MurineToxin, a Phospholipase D Superfamily Member
J Biol Chem 274(17): 11824-11831

Maehama, T. and Dixon, JE (1998)
The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate
J Biol Chem 273(22): 13375-13378

Denu, J.M., Stuckey, J.A., Saper, M.A., Dixon, JE (1996)
Form and Function in Protein Dephosphorylation
Cell 87(3): 361-364

Yuvaniyama, J., Denu, J.M., Dixon, JE, Saper, M.A. (1996)
Crystal Structure of the Dual-Specificity Protein Phosphatase VHR
Science 272(5266): 1328-1331

Denu, J.M., Lohse, D.L., Vijayalakshmi, J., Saper, M.A., Dixon, JE (1996)
Visualization of Intermediate and Transition-State Structures in Protein Tyrosine Phosphatase Catalysis
Proc Natl Acad Sci USA 93: 2493-2498

Schubert HL, Fauman EB, Stuckey JA, Dixon JE, Saper MA. (1995)
A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
Protein Sci (9):1904-13.

Stuckey, J.A., Schubert, H.L., Fauman, E.B., Zhang, Z.-Y., Dixon, JE, Saper, M.A. (1994)
Crystal Structure of Yersinia Protein Tyrosine Phosphatase at 2.5 angstom and the Complex with Tungstate
Nature 370(6490): 571-575

Guan, K., Hakes, D.J., Wang, Y., Park, H., Cooper, T.G., Dixon, JE (1992)
A Yeast Protein Phosphatase Related to the Vaccinia Virus VH1 Phosphatase is Induced by Nitrogen Starvation
Proc Natl Acad Sci USA 89: 12175-12179

Guan, K., Broyles, S.S., Dixon, JE (1991)
A Tyr/Ser Protein Phosphatase Encoded by Vaccinia Virus
Nature 350(6316): 359-362

Bliska, J.B., Guan, K., Dixon, JE, Falkow, S. (1991)
Tyrosine Phosphate Hydrolysis of Host Proteins by an Essential Yersinia Virulence Determinant
Proc Natl Acad Sci USA 88: 1187-1191

Guan, K. and Dixon, JE (1990)
Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia
Science 249(4968): 553-556