Current Lab Members

  • Larry Goldstein, Ph.D.
  • Mieko Ueno, Ph.D.
  • Angels Almenar, Ph.D.
  • Jonathan Boulanger-Weill
  • Sandra Encalada, Ph.D
  • Jessica Flippin
  • Cheryl Herrera
  • Mason Israel
  • Chelsea Kidwell
  • Rhiannon Killian
  • Emily Davis Niederst
  • Paulina Ordonez, M.D.
  • Liz Roberts,
  • Liz Rodrigues
  • Warren Plaisted
  • Jessica Rusert
  • Lukasz Szpankowski
  • Carole Weaver, Ph.D.
  • Zhaohuai Yang, Ph.D.
  • Jessica Young, Ph.D.
  • Shauna Yuan, M.D.

Larry Goldstein, Ph. D.
Principle Investigator
Investigator, Howard Hughes Medical Institute
Professor, Dept of Cellular & Molecular Medicine
Director, UC San Diego Stem Cell Program
email: lgoldstein@ucsd.edu
Tel: (858) 534-9702
Fax: (858) 534-8193

Educations:
B.A., Biology and Genetics, University of California, San Diego, 1976.
Ph.D., Genetics, University of Washington, Seattle, 1980.

Member:
American Academy of Arts and Sciences

Awards:
Public service award, American Society for Cell Biology
Loeb Chair in the Natural Sciences, Harvard University
American Cancer Society Faculty Research Award
Ellison Medical Foundation Senior Scholar Award in Aging Research

Co-Founder: Cytokinetics

Mieko Ueno(植野美枝子), Ph.D.
Lab Manager
email: goldsteinadmin@ucsd.edu
Tel: (858) 534-9700
Fax: (858) 534-8193

Educations:
Ph.D., Linguistics and Cognitive Science, University of California, San Diego, 2003
M.A., Linguistics, University of Michigan, Ann Arbor, 1997
B.A., Political Science, University of Michigan, Ann Arbor, 1990

Angels Almenar, Ph. D.Angels
Assistant Project Scientist
email: aalmenar@ucsd.edu
Tel: (858) 534-9703

Educations:
Post-doctoral Fellow, University of California San Diego - 2000-2005
Post-doctoral Fellow, The Scripps Research Institute (TSRI), Department of Cell Biology - 1999-2000
Ph.D. -TSRI, Department of Cell Biology & University of Barcelona, Spain, 1999
B.S. Biology - University of Barcelona, Spain - 1992


Jonathan Boulanger-Weill

email: jboulanger@ucsd.edu
Tel: (858) 534-9703






Sandra Encalada, Ph. D.Sandra_e
Damon Runyon Post-doctoral Fellow
email: sencalada@ucsd.edu
Tel: (858) 534-9703

Education:
Ph.D.,Molecular Biology, University of Oregon, 2003
M.S., Population Genetics, University of Florida, 1995
B.A., Physics (Biology minor), Earlham College, 1992

Research Interests:
My interest is to determine the mechanisms of axonal transport of prions and of the prion protein.

Selected Publications:
1. Encalada, S. E. and L. S. B. Goldstein. 2009. Prion Transport. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 7, pp. 1071-1075. Oxford: Academic Press.

2. Encalada, S. E., Willis, J., Lyczak, R., and B. Bowerman. 2005. A Spindle Checkpoint Functions During Mitosis in the Early C. elegans Embryo. Molecular Biology of the Cell, 16: 1056-1070.

3.Encalada, S. E., P. R. Martin, J. B. Phillips, R. Lyczak, D. R. Hamill, K. A. Swan, and B. Bowerman. 2000. DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos. Developmental Biology 228:225-238.


View all articles by Sandra Encalada

Jessica Flippin
Research Technician III
email: jflippin@ucsd.edu
Tel: (858) 534-9703

Research Interest:
I'm interested in the development of neuronal differentiation protocols to create a model system to elucidate the mechanisms involved in motor protein transport .

Selected publications:
1. Strunnikova N, Hilmer S, Flippin J, Robinson M, Hoffman E, Csaky KG. 2005. Differences in gene expression profiles in dermal fibroblasts from control and patients with age-related macular degeneration elicited by oxidative injury.Free Radic Biol Med. Sep 15;39(6):781-96.

2. Hathout Y, Flippin J, Fan C, Liu P, Csaky K. 2005
Metabolic labeling of human primary retinal pigment epithelial cells for accurate comparative proteomics. J Proteome Res. Mar-Apr;4(2):620-7.

3. Dreier B, Beerli RR, Segal DJ, Flippin JD, Barbas CF 3rd. 2001. Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem. Aug 3;276(31):29466-78.

View all articles by Jessica Flippin

Cheryl Herrera
Research Technician III
email: cmherrera@ucsd.edu
Tel: (858) 534-9703



Mason IsraelMason_I

Graduate Student in BMS
Sc.B., Biology, Brown University, 2003
email: misrael@ucsd.edu
Tel: (858) 534-9703

Research Interests:
My thesis project aims to create disease models of sporadic Alzheimer's disease using neurons derived from patient-specific stem cells. Although the vast majority of Alzheimer's disease (AD) is sporadic, analysis of cellular and animal models of the rare familial forms of AD have driven most ideas about the mechanisms that cause both familial and sporadic AD. Unclear, however, is whether sporadic AD is the same disease as familial AD and whether sporadic AD is only one disease. These issues are crucial to the development of new drugs and therapies targeting sporadic AD. The new methods of reprogramming fibroblasts into induced pluripotent stem cells provide a new way to tackle these problems and could lead to breakthroughs in our understanding of this common and devastating human neurodegenerative disorder. For the first time, it is possible to generate human, live, euploid, patient-specific neurons. We have started reprogramming primary cells from patients and control individuals and we are currently comparing differentiated cells derived from these individuals.


Publications:
Kumar R, Fossati V, Israel M, Snoeck HW. Lin-Sca1+kit- bone marrow cells contain early lymphoid-committed precursors that are distinct from common lymphoid progenitors. J Immunol. 2008 Dec 1; 181(11): 7507-13.

Chelsea Kidwell
Intern (CIRM Funded)
email: ckidwell@rohan.sdsu.edu
Tel: (858) 534-9703

Rhiannon KillianRhiannon_N
Graduate student
email: rnolan@ucsd.edu
Tel: (858) 534-9703

 

Emily Davis NiederstEmily_d
Graduate Student
email: eadavis@ucsd.edu
Tel: (858) 534-9703

 

Paulina Ordonez, M.D.
Assistant Professor of Pediatrics
email: mordonez@rchsd.org
Tel: (858) 534-9703

Education:
Doctor in Medicine and Surgery- Universidad Central del Ecuador, 2002
Internship and Residency in Pediatrics- University of Colorado Health Sciences Center, 2006
Fellowship in Pediatric Gastroenterology, Hepatology and Nutrition- University of California at San Diego, 2009

Research Interests:
I am interested in using human embryonic stem cells (hESC) to create models of disease. I am involved in the study of Niemann Pick type C (NPC), a progressive and lethal pediatric dementia that shares multiple features with Alzheimer's disease. I have generated a set of hESC with decreased expression of NPC1, the gene that is mutated in patients with NPC. Neurons derived from NPC1 knockdown hESC exhibit abnormal cellular phenotypes and impaired survival when compared to wild type hESC derived neurons. We are currently exploring the contribution of these pathological phenotypes on the development of disease and the mechanisms underlying neuronal failure in NPC1 knockdown human neurons.


Liz Roberts

Research Specialist
email: lizroberts@ucsd.edu
Tel: (858) 534-9703

Educations:
M.A. in Biology (Molecular Genetics), University of Kansas, 1993
B.A. in Psychology, University of Colorado, 1984

Selected Publications:
1. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillee S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH Jr, Julien JP, Goldstein LS, Cleveland DW. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice (2003). Science 302(5642):113-7.

2. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS.           
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP (2001). Nature 414 (6864):643-8.

3. Marszalek JR, Liu X, Roberts EA, Chui D, Marth JD, Williams DS, Goldstein LS (2000). Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell 102(2):175-87.
View all articles by Liz Roberts

Liz RodriguesLiz_Rodrigues
Graduate Students
email: emrodrigues@ucsd.edu
Tel: (858) 534-9703

 

Warren C. Plaisted
Intern (CIRM Funded)
email: warren.plaisted@gmail.com
Tel: (858) 534-9703

Education:
B.S. Biology - San Diego State University (2009)


Jessica Rusert
Biological Sciences Graduate Student
email: jrusert@ucsd.edu
Tel: (858) 534-9703

Education:
B.S. University of Wisconsin-Madison, 2002

Research Interests:
In collaboration with Catriona Jamieson's Lab at the Moores Cancer Center I am using human embryonic stem cells to model chronic myeloid leukemia (CML) and the leukemic stem cells (LSC) that drive this cancer. A hematopoietic stem cell has been identified and suggested to give rise to CML by acquisition of BCR-ABL, a fusion gene that produces a constitutively active protein tyrosine kinase product p210BCR-ABL. Efforts to model mechanisms of disease persistence and therapeutic resistance in human cells have been limited by the relative dearth of CML patient samples and the retrospective approach this necessitates. In addition, normal hematopoietic stem cells (HSC) are limiting due to their lack of abundance, genetic tractability, and expandability. Therefore, I are using human embryonic stem cells as a tool to study the development and progression of this disease.

Lukasz Szpankowski
Graduate student
email: lszpanko@ucsd.edu
Tel: (858) 534-9703

 

Carole Weaver, Ph.D.Carole
Post-doctoral Fellow
email: cweaver@ucsd.edu
Tel: (858) 534-9703

Educations:
Ph.D. Molecular & Cellular Biology - University of Washington, 2003
B.A. Molecular & Cell Biology - University of California Berkeley, 1995


Research Interests:
I am involved in characterizing the regulation of kinesin-based axonal transport in neurons, using the fruit fly Drosophila melanogaster. Drosophila larvae are an excellent system in which to study transport regulation due to the wide variety of molecular and genetic tools available in the fly, coupled with our ability to visualize and measure the movement of fluorescent proteins in CNS axons of living animals. I hope to identify genes using Drosophila that can be tested for roles in transport and neurodegenerative disease in mammalian neurons.

Selected Publications:
1. Weaver C, Kimelman D. Move it or lose it: axis specification in Xenopus. Development. 2004 Aug; 131(15):3491-9

2. Weaver C, Farr GH 3rd, Pan W, Rowning BA, Wang J, Mao J, Wu D, Li L, Larabell CA, Kimelman D. GBP binds kinesin light chain and translocates during cortical rotation in Xenopus eggs. Development. 2003 Nov;130(22): 5425-36

3. Graham TA, Weaver C, Mao F, Kimelman D, Xu W. Crystal structure of a beta-catenin/Tcf complex. Cell. 2000 Dec 8; 103(6):885-96.

View all articles by Carole Weaver

Zhaohui Yang, Ph.D
email: jouyang@ucsd.edu
Tel: (858) 534-9703

Educations:
Ph.D., Biochemistry, Baylor College of Medicine, 1993
B.S., Biochemistry, Beijing, Normal University, Beijing, China, 1987


Jessica Young, Ph.D.
A.P. Giannini Post-doctoral Fellow
email: jeyoung@ucsd.edu
Tel: (858) 534-9703

Education:
B.S. University of Wyoming, 1997
M.A. Sonoma State University, 2002
Ph.D. University of Washington, 2009


Research Interests:
1. Using human inducible pluripotent stem cells to develop neuronal models of Alzheimer’s disease (AD).
2.  Examining genetic polymorphisms that predispose individuals to sporadic AD.
3.  Using Zinc Finger Nuclease (ZFN) technology to target genes involved in both sporadic and familial AD.

Selected Publications:
1. Young JE and La Spada AR.  Development of selective nutrient deprivation as a system to study autophagy induction and regulation in neurons. Autophagy 2009.  May 16; 5(4): 555-57.
2. Young JE, Garden GA, Martinez R, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, and La Spada AR.  Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by JNK, c-Jun, and DP5/HRK.  J Neurosci. 2009. Feb 19; 29(7): 1987-97.
Young JE, Martinez RA, and La Spada AR.  Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.  J Biol Chem.  2009 Jan 23; 284(4): 2263-73.
4. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
J Biol Chem. 2007 Oct 12;282(41):30150-60.

View all articles by Jessica Young

Shauna Yuan, M.D.
emil: shyuan@ucsd.edu
Tel: (858) 534-9703

 



Alumni

Nelson R. Barton, Ph.D.
Vice-President
Research and Development
Verenium Corporation


Aaron B. Bowman, Ph.D.
Assistant Professor
Vanderbilt University
email: aaron.bowman@vanderbilt.edu

Valeria Cavalli, Ph.D.
Assistant Professor
Washington University in St. Louis
email: cavalli@wustl.edu


Jason Duncan, Ph.D.
Assistant Professor
Willamette University
email: jduncan@willamette.edu


Joseph Gindhart, Ph.D
Program director
NIGMS
email: gindhartjg@nigms.nih.gov


Shermali Gunawardena, Ph.D.
Assistant Professor
University at Buffalo
The State University of New York
email: sg99@bio.buffalo.edu


Tomas Falzone, PhD.
Assistant Professor
IBCN-CONICET, University of Buenos Aires
email:
tfalzone@fmed.uba.ar

Margarete M. S. Heck, Ph.D.
Professor
University of Edinburgh
email: margarete.heck@ed.ac.uk

Lu Shiun Her, Ph.D.
Assistant Professor
National Cheng Kung University
email: lsher@mail.ncku.edu.tw


Carla Tucker Lee, Ph.D. & M.D.
Assistant clinical professor
Vanderbilt University
email: carla.lee@vanderbilt.edu

Joseph R Marszalek, Ph.D.
Associate Director
Target Biology, Validation and Drug Discovery
Belfer Institute for Applied Cancer Science
Dana-Farber Cancer Institute

Maura McGrail, Ph.D.
Adjunct Assistant Professor
Iowa State University
email: mmcgrail@iastate.edu

Patricia A. Pesavento, DVM, Ph.D.
Associate Professor
UC Davis
email: papesavento@ucdavis.edu


Sameer Shah, Ph.D.
Assistant Professor
University of Maryland
email: sameer@umd.edu

Hernando Sosa, Ph.D.
Associate Professor
Albert Einstein College of Medicine
email: hsosa@aecom.yu.edu


Jagesh V. Shah, Ph.D.
Assistant Professor
Harvard Medical School
email: jagesh_shah@hms.harvard.edu


Jane Atienza
Kristi G. Bache, Ph.D.
Richard Brusch
Roberto Carlos
Brady Culver
Brian Dalby, Ph.D.
Tomas Falzone, Ph.D.
Sam Farlow
Eric Ginoux
Brian W Guzik, Ph.D.
Marjan Haghnia, Ph.D.
David W. Hanlon, Ph.D.
Adeela Kamal, Ph.D.
Nikole Kimes
Anne Kuller
Robert Laymon
John Lee, Ph.D.
Heinrich J.G. Matthies, Ph.D.
Stephanie Mount
Diane Munroe
Andrea J. Pereira, Ph.D.
Alastair Valentine Philp, Ph.D.
Amena Rahman, Ph.D.
Krishanu Ray, Ph.D.
Gerald Reis, Ph. D.
Bruce W. Ritchings
Roman Sakowicz, Ph.D.
Melanie Segui
Kristina Schimmelpfeng, Ph.D.
Louis Sintasath
Gorazd B. Stokin, Ph.D.
Ming Tsai
Eileen Westerman
Grainne Whitman
Chun-Hong Xia, Ph.D.

Alumni:
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