Tuesdays and/or Thursdays, 5 PM to 7+ PM, Location TBA
Instructor: Anthony Wynshaw-Boris (awynshawboris@ucsd.edu)
Syllabus and reading list. Winter quarter, 2005
| Class | Faculty |
|---|---|
| Class 1. Introduction to the class Thursday January 6 Goals, grading, distribution of first paper, assignment of dicussion leaders |
Anthony Wynshaw-Boris |
| Class 2. Origins of a particulate view of heredity. Thursday, January 13 Mendel, J. Gregor (1866) Experiments in plant hybridization. Verhandlungen des naturforschenden Vereines in Brünn. 4: 3-47. Background material in "Origins of Mendelism" Robert C. Olby, (1966) Schocken Books Inc. New York |
Anthony Wynshaw-Boris |
| Class 3. Genes and proteins. Tuesday, January 18 Garrod, Archibald, E. (1902) The incidence of alkaptonuria: a study in chemical individuality. Lancet ii: 1616-1620. Beadle, G.W. and Tatum, E.L. (1941) Genetic control of biochemical reactions in Neurospora. Proc. Natl. Acad. Sci. USA. 27: 499-506 |
Ted Friedman Scott Emr Anthony Wynshaw-Boris |
| Class 4. Chromosomal Basis of Inheritance. Tuesday, February 1 Morgan, T. H. 1910. Sex-limited inheritance in Drosophila, Science 32: 120-122. Bridges, C. B. 1914. Direct proof through non-disjunction that the sex-linked genes of Drosophila are borne on the X-chromosome. Science, NS vol XL:107 109. Bridges, C. B. 1916. Non-disjunction as proof of the chromosome theory of inheritance. Genetics 1:1 52, 107-163. |
Anthony Wynshaw-Boris |
| Class 5. The genesis and mapping of genetic variants. Thursday, February 3 Luria, S.E. and Delbrück M. (1943) Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28: 491 Sturtevant, A.H. (1913) The linear arrangment of six sex-linked factors in Drosophila, as shown by their mode of association. J. Exp. Zool. 14: 43-59. |
Scott Emr Bruce Hamilton Anthony Wynshaw-Boris |
| Class 6. Genes and DNA. Thursday, February 10 Avery, O.T., Macleod, C.M., and McCarty, M. (1944) Studies of the chemical nature of the substance inducing transformation of pneumococcal types. J. Exp. Med. 79: 137-158. Watson, J.D. and Crick, F.H.C. (1953) Molecular stucture of Nucleic Acids, a structure for Deoxyribose nucleic acid. Nature 171: 737-738 |
Scott Emr Anthony Wynshaw-Boris |
| Class 7. Mobile genetic elements. Thursday, February 17 McClintock, B. (1950) The origin and behavior of mutable loci in maize. Proc. Natl. Acad. Sci. USA. 36: 344-355. |
Anthony Wynshaw-Boris |
| Class 8. Genes and cancer/cell cycle. Tuesday, February 22 Knudson, A.G. (1971) Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA. 68: 820-823. Hartwell, L.H., Culotti, J., Reid, B. (1970) Genetic control of cell division in yeast, I. Detection of mutants. Proc. Natl. Acad. Sci. USA. 66: 352-359. |
Anthony Wynshaw-Boris |
| Class 9. Genes and developmental pathways. Thursday, March 3 Jacob, F. and J. Monod (1961) Genetic regulatory mechanisms in the synthesis of proteins. J. Mol .Biol. 3: 318-356. Lewis, E.B. (1978) A gene complex controlling segmentation in Drosophila. Nature 276, 565-570. Nüsslein-Volhard, C. and Wieschaus, E. (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287: 795-801 |
Scott Emr Joe Gleeson Anthony Wynshaw-Boris |
| Class 10. Modifier Genes. Tuesday March 8 Altenberg, E. and Muller, H.J. (1915) The genetic basis of truncate wing,- and inconstant and modifiable character in Drosophila. Genetics 5:1-59. |
Bruce Hamilton Nik Schork Anthony Wynshaw-Boris |
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| Electronic Scholarly Publishing has electronic versions of many of these papers, as well as Sturtevant's book, "A History of Genetics." |  |