Vered Padler-Karavani (vkaravan)
Postdoctoral Fellow
Vered obtained B.Sc in Life Scieces ( Magna cum laude ) and M.Sc ( Magna cum laude ) and Ph.D in Biochemistry from Tel-Aviv University, Israel. During her training with Prof. Nathan Nelson she studied Structure-function relationship in the V-ATPase complex from the yeast Saccharomyces cerevisiae using molecular biology and biochemistry techniques. These studies shed light on the rotary mechanism of the eukaryotic V-ATPase, its involvement in endocytosis and the specific features that distinguishes it from the prokaryotic F-ATPase. Vered is a member of ISEF Foundation since 1994. She joined the Varki lab for her postdoctoral training in Glycobiology on December 2005. Her current interest is to study the immunological aspects of the non-human sialic acid, N-glycolylneuraminic acid, and to investigate its potential in cancer prognosis, diagnosis and therapy.
PUBLICATIONS
Aviezer-Hagai K # , Padler-Karavani V # , Nelson N. (2003) Biochemical support for the V-ATPase rotary mechanism: antibody against HA-tagged Vma7p or Vma16p but not Vma10p inhibits activity. J Exp Biol . 206 : 3227-37. ( # equally contributed).
Perzov N, Padler-Karavani V, Nelson H, Nelson N. (2002) Characterization of yeast V-ATPase mutants lacking Vph1p or Stv1p and the effect on endocytosis. J Exp Biol. 205 : 1209-19.
Perzov N, Padler-Karavani V, Nelson H, Nelson N. (2001) Features of V-ATPases that distinguish them from F-ATPases. FEBS Lett . 504 : 223-8.
Nelson N, Perzov N, Cohen A, Hagai K, Padler V, Nelson H. (2000) The cellular biology of proton-motive force generation by V-ATPases. J. Exp. Biol . 1 : 89-95.
Padler-Karavani, Hai Yu, Harshal Chokhawala, Xi Chen and Ajit Varki (2006) The Broad and Variable Spectrum of Circulating Anti-N-glycolylneuraminic Acid Antibodies in Normal Humans. Glycobiology 2006 Annual Conference of The Society for Glycobiology, LA, USA.
Padler-Karavani V, Aviezer-Hagai K, and Nelson N (2005) Biochemical support for the V-ATPase rotary mechanism as revealed by antibodies against HA-tagged subunits. The forth congress of the Federation of the Israel Societies for Experimental Biology (FISEB), Eilat, Israel.
Padler-Karavani V, and Nelson N (2004) Random Chimeras between Vma11p and Vma3p and their Complementation of the Saccharomyces cerevisiae V-ATPase Null Mutants. Annual meeting of ISBMB, Tel-Aviv university, Israel.
Padler-Karavani V, and Nelson N (2004) Random Chimeras between Vma11p and Vma3p and their Complementation of the Saccharomyces cerevisiae V-ATPase Null Mutants. ASBMB Annual Meeting and 8th IUBMB Conference, Boston, Massachusetts, USA.
Padler-Karavani V, Aviezer-Hagai K, and Nelson N (2003) Inhibition of V-ATPase activity by anti-HA antibody in yeast expressing HA-tagged Vo subunits. Annual meeting of ISBMB, Tel-Aviv university, Israel.
Perzov N, Padler-Karavani V, Nelson H, Nelson N. (2001) Characterization of V-ATPase mutants in yeast cells. Annual meeting of ISBMB, Jerusalem university, Israel.
Nelson N, Perzov N, Cohen A, Hagai K, Padler V, and Nelson H (1999) The cellular biology of proton-motive force generation by V-ATPase. Proton-motive ATPases. Millennium Symposium, Sidney-Sussex college, Cambridge university, England.