Benjamin Vitre, Andrew J. Holland, Anita Kulukian, Ofer Shoshani, Maretoshi Hirai, Yin Wang, Marcus Maldonado, Thomas Cho, Jihane Boubaker, Deborah A. Swing, Lino Tessarollo, Sylvia M. Evans, Elaine Fuchs, and Don W. Cleveland (2015). Chronic centrosome amplification without tumorigenesis. PNAS E6321-E6330

 

Marka van Blitterswijk, Tania F. Gendron, Matthew C. Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Patricia H. Brown, Lillian M. Daughrity, Melissa E. Murray, Michael G. Heckman, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W. Cleveland, Keith A. Josephs, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Leonard Petrucelli, Bradley F. Boeve, Neill R. Graff-Radford, Kevin B. Boylan, Dennis W. Dickson, Rosa Rademakers (2015). Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol (2015) 130:863–876

 

Shuying Sun, Ying Sun, Shuo-Chien Ling, Laura Ferraiuolo, Melissa McAlonis-Downes, Yiyang Zou, Kevin Drenner, Yin Wang, Dara Ditsworth, Seiya Tokunaga, Alex Kopelevich, Brian K. Kaspar, Clotilde Lagier-Tourenne, and Don W. Cleveland (2015). Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. PNAS 112, E6993-E7002

 

Meghdad Rahdar, Moira A. McMahon, Thazha P. Prakash, Eric E. Swayze, C. Frank Bennett, and Don W. Cleveland (2015). Synthetic CRISPR RNA-Cas9–guided genome editing in human cells. PNAS 112, E7110-E7117

 

Jacqueline C Mitchell, Remy Constable, Eva So, Caroline Vance, Emma Scotter, Leanne Glover, Tibor Hortobagyi, Eveline S. Arnold, Shuo-Chien Ling, Melissa McAlonis, Sandrine Da Cruz, Magda Polymenidou, Lino Tessarolo,Don W Cleveland and Christopher E Shaw (2015). Wild type human TDP-43 potentiates ALSlinked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS. Acta Neuropathologica Communications 3, 36-51

 

Anita Kulukiana, Andrew J. Hollandb, Benjamin Vitrec, Shruti Naika, Don W. Cleveland, and Elaine Fuchsa (2015). Epidermal development, growth control, and homeostasis in the face of centrosome amplification. PNAS E6311-E6320

 

Andrew J. Hollanda, Rita M. Reisb, Sherry Niessend, Cláudia Pereirab, Douglas A. Andrese, H. Peter Spielmanne, Don W. Cleveland, Arshad Desaia, and Reto Gassmannb (2015). Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell 26, 1845-1856

 

Tania F. Gendron, Marka van Blitterswijk, Kevin F. Bieniek, Lillian M. Daughrity, Jie Jiang, Beth K. Rush, Otto Pedraza, John A. Lucas, Melissa E. Murray, Pamela Desaro, Amelia Robertson, Karen Overstreet, Colleen S. Thomas, Julia E. Crook, Monica Castanedes-Casey, Linda Rousseau, Keith A. Josephs, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Bradley F. Boeve, Neill R. Graff-Radford, Rosa Rademakers, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W. Cleveland, Dennis W. Dickson, Leonard Petrucelli, Kevin B. Boylan (2015). Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathol (2015) 130:559–573

 

Stefano Bertuzzi and Don W. Cleveland (2015). The curious incident of the translational dog that didn't bark. Trends in Cell Biology April 2015, Vol. 25, No. 4

 

Caroline Topham, Anthony Tighe, Peter Ly, Ailsa Bennett, Olivia Sloss, Louisa Nelson, Rachel A. Ridgway,
David Huels, Samantha Littler, Claudia Schandl, Ying Sun, Beatrice Bechi, David J. Procter, Owen J. Sansom, Don W. Cleveland, and Stephen S. Taylor (2015). MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell 28, 129–140

 

Daniele Fachinetti, Joo Seok Han, Moira A. McMahon, Peter Ly, Amira Abdullah, Alex J. Wong, andDon W. Cleveland (2015). DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. Developmental Cell 33, 314–327

 

Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marian Hruska-Plochan,
Melissa McAlonis-Downes, Salah Abu-Hamad, Guy Zoltsman, Tom Shani, Marcus Maldonado, Anh Bui,
Michael Navarro, Huilin Zhou, Martin Marsala, Brian K. Kaspar, Sandrine Da Cruz, and Don W. Cleveland (2015). Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron 86, 218–232.

 

Shuying Sun, Shuo-Chien Ling, Jinsong Qiu, Claudio P. Albuquerque, Yu Zhou, Seiya Tokunaga, Hairi Li, Haiyan Qiu, Anh Bui, Gene W. Yeo, Eric J. Huang, Kevin Eggan, Huilin Zhou, Xiang-Dong Fu, Clotilde Lagier-Tourenne & Don W. Cleveland (2015). ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. NATURE COMMUNICATIONS | 6:6171 | DOI: 10.1038/ncomms7171

 

Sandrine Da Cruz and Don W. Cleveland (2016). Disrupted nuclear importexport in neurodegeneration: Toxicity arises from amyloid-like protein accumulation in the cytoplasm, not the nucleus. Science 351, 125-126

 

Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis-Downes, Amanda Seelman, Jennifer E. Stauffer, Paymaan Jafar-nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo-Chien Ling, Brian Myers, Jeffery Engelhardt, Melanie Katz, Michael Baughn, Oleksandr Platoshyn, Martin Marsala, Andy Watt, Charles J. Heyser, M. Colin Ard, Louis De Muynck, Lillian M. Daughrity, Deborah A. Swing, Lino Tessarollo, Chris J. Jung, Arnaud Delpoux, Daniel T. Utzschneider, Stephen M. Hedrick, Pieter J. de Jong, Dieter Edbauer, Philip Van Damme, Leonard Petrucelli, Christopher E. Shaw, C. Frank Bennett, Sandrine Da Cruz, John Ravits, Frank Rigo., Don W. Cleveland and Clotilde Lagier-Tourenne (2016). Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides TargetingGGGGCC-ContainingRNAs. Neuron 90, 1-6

 

Annelies Quaegebeur, Inmaculada Segura, Roberta Schmieder, Dries Verdegem, Ilaria Decimo, Francesco Bifari, Tom Dresselaers, Guy Eelen, Debapriva Ghosh, Shawn M. Davidson, Sandra Schoors, Dorien Broekaert, Bert Cruys, Kristof Govaerts, Carla De Legher, Ann Bouche´, Luc Schoonjans, Matt S. Ramer, Gene Hung, Goele Bossaert, Don W. Cleveland, Uwe Himmelreich, Thomas Voets, Robin Lemmens, C. Frank Bennett, Wim Robberecht, Katrien De Bock, Mieke Dewerchin, Bart Ghesquie`re, Sarah-Maria Fendt, and Peter Carmeliet (2016). Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metabolism 23, 280-291

 

Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Ya-Fei Xu, Rebecca B Katzman, Jennifer Gass, Melissa E Murray, Mitsuru Shinohara, Wen-Lang Lin, Aliesha Garrett, Jeannette N Stankowski, Lillian Daughrity, Jimei Tong, Emilie A Perkerson, Mei Yue, Jeannie Chew, Monica Castanedes Casey, Aishe Kurti, Zizhao S Wang, Amanda M Liesinger, Jeremy D Baker, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W Cleveland, Rosa Rademakers, Kevin B Boylan, Guojun Bu, Christopher D Link, Chad A Dickey, Jeffrey D Rothstein, Dennis W Dickson, John D Fryer & Leonard Petrucelli (2016). C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience doi:10.1038/nn.4272

 

Sebastian Hoffmann, Marie Dumont, Viviana Barra, Peter Ly, Yael Nechemia-Arbely, Moira A. McMahon, Solene Herve, Don W. Cleveland, and Daniele Fachinetti (2016).  CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly.  Cell Reports 17, 2394–2404

 

Moira A. McMahon and Don W. Cleveland (2016). Gene-editing therapy for neurological disease. Nature Reviews Neurology 13:7–9 (2017)

 

Magdalini Polymenidou and Don W. Cleveland (2016). Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a024133

 

Tamara Seredenina, Zeynab Nayernia, Silvia Sorce, Ghassan J. Maghzal, Aleksandra Filippova, Shuo-Chien Ling, Olivier Basset, Olivier Plastre, Youssef Daali, Elisabeth J. Rushing, Maria T. Giordana, Don W. Cleveland, Adriano Aguzzi, Roland Stocker, Karl-Heinz Krause, Vincent Jaquet (2016). Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biology and Medicine 97 (2016) 95–108

 

J. Paul Taylor, Robert H. Brown Jr & Don W. Cleveland (2016). Decoding ALS: from genes to mechanism. Nature 539, 197-206

 

Qiaozhen Ye, Dong Hyun Kim, Ihsan Dereli, Scott C Rosenberg, Goetz Hagemann, Franz Herzog, Attila Tóth, Don W Cleveland & Kevin D Corbett (2017).  The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.  The EMBO Journal (2017) Vol 36, No 16

 

Fen-Biao Gao, Joel D. Richter, and Don W. Cleveland (2017).  Rethinking Unconventional Translation in Neurodegeneration.  Cell 171, 994-1000

 

Peter Ly and Don W.Cleveland (2017). Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis.  Trends in Cell Biology, 27: 917-930

 

Sandrine Da Cruz, Anh Bui, Shahram Saberi, Sandra K. Lee, Jennifer Stauffer, Melissa McAlonis-Downes, Derek Schulte, Donald P. Pizzo, Philippe A. Parone, Don W. Cleveland, John Ravits (2017).  Misfolded SOD1 is not a primary component of sporadic ALS.  Acta Neuropathol (2017) 134:97–111

 

Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page and Don W. Cleveland (2017). Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining.  NATURE CELL BIOLOGY VOLUME 19 | NUMBER 1 | JANUARY 2017

 

Peter Ly and Don W. Cleveland (2017).  Interrogating cell division errors using random and chromosome-specific missegregation approaches.  CELL CYCLE 2017, VOL. 16, NO. 13, 1252–1258

 

Dara Ditsworth, Marcus Maldonado, Melissa McAlonis-Downes, Shuying Sun, Amanda Seelman, Kevin Drenner, Eveline Arnold, Shuo-Chien Ling, Donald Pizzo, John Ravits, Don W. Cleveland*, and Sandrine Da Cruz1* (2017). Mutant TDP-43 within motor neurons drives disease onset but not progression in Amyotrophic Lateral Sclerosis. Acta Neuropathol, March 2017

 

Fatima Gasset-Rosa, Carlos Chillon-Marinas, Alexander Goginashvili, Ranjit Singh Atwal, Jonathan W. Artates, Ricardos Tabet, Vanessa C. Wheeler, Anne G. Bang, Don W. Cleveland* and Clotilde Lagier-Tourenne* (2017). Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron 94, 48–57, April 5, 2017

 

Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman & Ben E. Black (2017).  Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchordependent nucleosome transition.  NATURE COMMUNICATIONS | 8:15775

 

Michelle S. Levine, Bjorn Bakker, Bram Boeckx, Julia Moyett, James Lu, Benjamin Vitre, Diana C. Spierings, Peter M. Lansdorp, Don W. Cleveland, Diether Lambrechts, Floris Foijer, and Andrew J. Holland* (2017).Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Developmental Cell 40, 313–322, February 6, 2017

 

Moira A. McMahon and Don W. Cleveland (2017). Gene-editing therapy for neurological disease. Nature rev Neurol 13, 7-9

 

Yael Nechemia-Arbely, Daniele Fachinetti, Karen H. Miga, Nikolina Sekulic, Gautam V. Soni, Dong Hyun Kim, Adeline K. Wong, Ah Young Lee, Kristen Nguyen, Cees Dekker, Bing Ren, Ben E. Black, and Don W. Cleveland (2017) Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J. Cell Biol. Vol. 216 No. 3 607–621

 

Magdalini Polymenidou and Don W. Cleveland (2017).Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med.

 

Jone Lopez-Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, Joshua N. Asiaban, Jonathan Artates, Anh T. Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Melanie Jambeau, Jihane Boubaker, Deborah Swing, Jinsong Qiu, Geoffrey G. Hicks, Zhengyu Ouyang, Xiang-Dong Fu, Lino Tessarollo, Shuo-Chien Ling, Philippe A. Parone, Christopher E. Shaw, Martin Marsala, Clotilde Lagier-Tourenne, Don W. Cleveland, and Sandrine Da Cruz (2018). ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron Volume 100, Issue 4, 21 November 2018, Pages 816-830.e7

 

Dong Hyun Kim, Joo Seok Han, Peter Ly, Qiaozhen Ye, Moira A. McMahon, Kyungjae Myung, Kevin D. Corbett & Don W. Cleveland (2018). TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced
MCC. Nat Commun. 2018 10 19; 9(1):4354

 

Craig L. Bennett, Somasish G. Dastidar, Shuo-Chien Ling, Bilal Malik, Travis Ashe, Mandheer Wadhwa, Derek B. Miller, Changwoo Lee, Matthew B. Mitchell, Michael A. van Es, Christopher Grunseich, Yingzhang Chen, Bryce L. Sopher, Linda Greensmith, Don W. Cleveland, Albert R. La Spada (2018). Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathologica (2018) 136:425–443

 

Haiyang Yu and Don W. Cleveland (2018). Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. Cell Volume 174, Issue 6, 6 September 2018, Pages 1339-1341

 

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, and Cantley LC (2018). Chromosomal instability drives metastasis through a cytosolic DNA response.  Nature (2018) 553, 467-475

 

Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland & Shuying Sun (2018).  C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation.  Nature Communications (2018) 9:51

 

Nikita Gudimchuk, Ekaterina V. Tarasovetc, Vadim Mustyatsa, Alexei L. Drobyshev, Benjamin Vitre, Don W. Cleveland, Fazly I. Ataullakhanov, and Ekaterina L. Grishchuk (2018). Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. Biophysical Journal 114, 2640–2652, June 5, 2018

 

Moira A. McMahon, Thazha P. Prakash, Don W. Cleveland, C. Frank Bennett, and Meghdad Rahdar (2018). Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Molecular Therapy Vol. 26 No 5 May 2018

 

Shahram Saberi, Jennifer E. Stauffer, Jie Jiang, Sandra Diaz Garcia, Amy E. Taylor, Derek Schulte, Takuya Ohkubo, Cheyenne L. Schloffman, Marcus Maldonado, Michael Baughn, Maria J. Rodriguez, Don Pizzo, Don Cleveland, John Ravits (2018). Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathologica (2018) 135:459–474

 

Peter Ly, Simon F. Brunner, Ofer Shoshani, Dong Hyun Kim, Weijie Lan, Tatyana Pyntikova, Adrienne M. Flanagan, Sam Behjati, David C. Page, Peter J. Campbell and Don W. Cleveland (2019). Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nature Genetics 51, 705-715 (2019)

 

Ze’ev Melamed1, Jone López-Erauskin, Michael W. Baughn, Ouyang Zhang, Kevin Drenner, Ying Sun, Fernande Freyermuth, Moira A. McMahon, Melinda S. Beccari, Jon W. Artates, Takuya Ohkubo, Maria Rodriguez, Nianwei Lin, Dongmei Wu, C. Frank Bennett, Frank Rigo, Sandrine Da Cruz, John Ravits, Clotilde Lagier-Tourenne and Don W. Cleveland (2019). Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nature Neuroscience 22, 180-190 (2019)

 

Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black & Daniele Fachinetti (2019). Phosphorylation of CENP-A on serine 7 does not control centromere function. Nature Communications 10, Article number: 175(2019)

 

Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland (2019). Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. eLife 2019;8:e40811

 

Fatima Gasset-Rosa, Shan Lu, Haiyang Yu, Cong Chen, Ze’ev Melamed, Lin Guo, James Shorter, Sandrine Da Cruz, and Don W. Cleveland (2019). Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron Volume 102, Issue 2, 17 April 2019, Pages 339-357.e7