Marten Hoeksema, PhD

Postdoctoral Fellow

Marten Hoeksema

EDUCATION

University of Amsterdam, Amsterdam, the Netherlands - department of Medical Biochemistry - Ph.D. (2016)

Maastricht University, Maastricht, the Netherlands - Clinical Molecular Sciences - M.Sc. (2010)

Maastricht University, Maastricht, the Netherlands - Molecular Life Sciences - B.Sc. (2008)


RESEARCH INTERESTS

  • Macrophage function
  • Epigenomics
  • Signaling pathways

  • AWARDS

    NWO-ALW Rubicon grant, the Netherlands (2016)

    Postdoc grant Amsterdam Cardiovascular Institute, the Netherlands (2016)

    Postdoc grant CVON, Dutch Heart Foundation, the Netherlands (2015)

    EMDS Travel Award, EMDS, Vienna, Austria (2014)

    Best oral presenta on award, Rembrandt Meeting, Noordwijkerhout, the Netherlands (2013)

    BIF Travel Grant, Boehringer Ingelheim, Germany (2012)

    Kootstra Fellowship, Maastricht University, the Netherlands (2010)


    SELECTED PUBLICATIONS

    van der Vorst EP, Theodorou K, Wu Y, Hoeksema MA, Goossens P, Bursill CA, Aliyev T, Huitema LF, Tas SW, Wolfs IM, Kuijpers MJ, Gijbels MJ, Schalkwijk CG, Koonen DP, Abdollahi-Roodsaz S, McDaniels K, Wang CC, Leitges M, Lawrence T, Plat J, Van Eck M, Rye KA, Touqui L, de Winther MP, Biessen EA, Donners MM. High-density lipoproteins exert pro-inflammatory effects on macrophages via passive cholesterol depletion and PKC-NF-κB/STAT1-IRF1 signaling. Cell Metab. 2016 Nov 16.

    Hoeksema MA & de Winther MP. Epigenetic regulation of monocytes and macrophages. Antioxid Redox Signal. 2016 Nov 10;25(14):758-774.

    Hoeksema MA, Laan LC, Postma JJ, Cummings R, de Winther MP, Dijkstra CD, van Die I, Kooij G. Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. FASEB J. 2016 Apr 19.

    Hoeksema MA, Scicluna BP, Boshuizen MC, van der Velden S, Neele AE, Van den Bossche J, Matlung HL, van den Berg TK, Goossens P, de Winther MP. IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment. J Immunol. 2015 Apr 15;194(8):3909-16.

    Hoeksema MA, Gijbels MJ, Van den Bossche J, van der Velden S, Sijm A, Neele AE, Seijkens T, Stöger JL, Meiler S, Boshuizen MC, Dallinga-Thie GM, Levels JH, Boon L, Mullican SE, Spann NJ, Cleutjens JP, Glass CK, Lazar MA, de Vries CJ, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med. 2014 Jul 9;6(9):1124-32.

    Seijkens T, Hoeksema MA, Beckers L, Smeets E, Meiler S, Levels J, Tjwa M, de Winther MP, Lutgens E. Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis. FASEB J. 2014 May;28(5):2202-13.

    Hoeksema MA, Stöger JL, de Winther MP. Molecular pathways regulating macrophage polarization: implications for atherosclerosis. Curr Atheroscler Rep. 2012 Jun;14(3):254-63.


    PUBMED SEARCH

    HOEKSEMA, MA

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