Alexi Nott

Assistant Project Scientist

Sascha Duttke


MRC - Laboratory of Molecular and Cell Biology, University College London, UK. PhD (2009)

University of Bath, Department of Biology and Biochemistry, UK. B.Sc. (2005)


  • Cell-type specific gene regulation and epigenetics of the healthy brain and in neurological disorders.


    Alzheimer’s Association Research Fellowship (2017 – present)

    Medical Research Council graduate student. Laboratory of Molecular Cell Biology, University College London. Doctor of Philosophy Degree, Mentor: Prof. A. Riccio (2005 - 2008)

    Charlotte and Yule Bogue Research Fellowship, University College London, UK (2007)

    Mbiochem, First-class Honours. University of Bath, UK (2001-2005)


    NOTT, A., Glass, C.K. Immune memory in the brain. (2018) Nature. 556(7701):312-313.

    NOTT, A., Cheng, J., Gao, F., Lin, Y.-T., Gjoneska, E., Ko, T., Minhas, P., Zamudio, A.V., Meng, J., Zhang, F., Jin, P., Tsai, L.-H. Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. (2016) Nature Neuroscience. 19(11):1497-1505.

    Seneviratne*, U., NOTT*, A., Bhat, V., Kodihalli, R., Wishnok, J., Tsai, L.-H., Tannenbaum, S.R. S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration. (2016) Proc Natl Acad Sci USA. 113(15):4152-7. *Authors contributed equally

    Nitarska, J., Smith, J.G., Sherlock, W.T., Hillege, M.H.H., NOTT, A., Barshop, W.D., Vashisht, A.A., Wohlschlegel, J.A., Mitter, R., Riccio, A. A functional switch of the NuRD chromatin remodeling complex subunits regulates mouse cortical development. (2016) Cell Reports. 17:1683-98.

    Durak, O., Gao, F., Kaeser-Woo, Y.J., Rueda, R., Martorell, A., NOTT, A., Liu, C.Y., Watson, L.A., Tsai, L.-H. The chromatin remodeler Chd8 transcriptionally regulates cell cycle and neurogenesis in the developing mouse cortex. (2016) Nature Neuroscience. 19(11):1477-1488.

    NOTT*, A., Cho*, S., Seo, J., Tsai, L.-H. HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex. (2015) Neuroepigenetics. 1(1):34-40. *Authors contributed equally

    Madabhushi, R., Gao, F., Pfenning, A.R., Pan, L., Yamakawa, S., Seo, J., Rueda, R., Phan, T.X., Yamakawa, H., Pao, P.C., Stott, R.T., Gjoneska, E., NOTT, A., Cho, S., Kellis, M., Tsai, L.-H. Activity-induced DNA breaks govern the expression of neuronal early-response genes. (2015) Cell. 161(7):1592-605.

    NOTT, A., Nitarska, J., Veenvliet, J.V., Schacke, S., Derijck, A.A., Sirko, P., Muchardt, C., Pasterkamp, J., Smidt, M.P., Riccio, A. S-Nitrosylation of HDAC2 regulates the expression of the chromatin remodeling factor Brm during radial neuron migration. (2013) Proc Natl Acad Sci USA. 110(8):3113-8.

    NOTT, A., Watson, P.M., Robinson, J.D., Crepaldi, L., Riccio, A. S-nitrosylation of histone deacetylase 2 induces chromatin remodeling in neurons. (2008) Nature. 455(7211):411-5.

    NOTT, A., Levin, E.D. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. (2006) Brain Research. 1081(1):72-8.


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