Nathan Spann, PhD

Project Scientist

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EDUCATION

San Diego State University, Cellular & Molecular Biology - Ph.D. (2006)

Governors State University, Biology - B.S. (1999)


RESEARCH INTERESTS

  • NCoR repression
  • Lipids and transcription factors

  • AWARDS

    ARCS Foundation, San Diego, Chapter

    Achievement Rewards for College Scientists (ARCS) Scholarship (2002-2005)

    Governors State Alumni Scholarship (1997-1998)


    SELECTED PUBLICATIONS

    Gosselin DO*, Link VM*, Romanoski CE*, Fonseca GJ, Eichenfield DJ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell. 2014 Dec 4.

    Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen M, Lam M, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CRH, Sullards MC, Murphy RC, Merrill Jr. AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. 25-Hydroxycholesterol Activates the Integrated Stress Response to Reprogram Transcription and Translation in Macrophages. Journal of Biological Chemistry. 2013 Dec 13;288(50):35812-23. PMID24189069; PMC3861632

    Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, Auwerx J, Glass CK, Olefsky JM. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 2013 Sep 26;155(1):200-14. PMIC: 24074869

    Spann NJ, Glass CK.Sterols and oxysterols in immune cell function. Nat Immunol. 2013 Sep;14(9):893-900. PMID: 23959186

    Kaikkonen MU*, Spann NJ*, Heinz S, Romanoski CE, Allison KA, Stender JD, Chun HB, Tough DF, Prinjha RK, Benner C, Glass CK. Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription. Molecular Cell. 2013 Aug 8;51(3):310-25. PMID23932714; PMC3779836

    Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell DW, Glass CK. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 2012 Sep 28;151(1):138-52. PMID: 23021221 PMCID: PMC3464914

    Escoubet-Lozach L, Benner C, Kaikkonen MU, Lozach J, Heinz S, Spann NJ, Crotti A, Stender J, Ghisletti S, Reichart D, Cheng CS, Luna R, Ludka C, Sasik R, Garcia-Bassets I, Hoffmann A, Subramaniam S, Hardiman G, Rosenfeld MG, Glass CK. Mechanisms establishing TLR4-responsive activation states of inflammatory response genes. PLoS Genet. 2011 Dec;7(12):e1002401. Epub 2011 Dec 8.

    Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J. 2010 Dec 15;29(24):4223-36. Epub 2010 Nov 2.

    Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010 May 28;38(4):576-89.

    Hui ST, Andres AM, Miller AK, Spann NJ, Potter DW, Post NM, Chen AZ, Sachithanantham S, Jung DY, Kim JK, Davis RA. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3921-6. Epub 2008 Mar 5.

    Spann NJ, Kang S, Li AC, Chen AZ, Newberry EP, Davidson NO, Hui ST, Davis RA. Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis. J Biol Chem. 2006 Nov 3;281(44):33066-77. Epub 2006 Aug 31.

    Kang S, Spann NJ, Hui TY, Davis RA. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. J Biol Chem. 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.

    Davis RA, Miyake JH, Hui TY, Spann NJ. Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J Lipid Res. 2002 Apr;43(4):533-43.


    PUBMED SEARCH

    SPANN, NJ

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    University of California, San Diego School of Medicine
                              University of California, San Diego