Coalition for the Life Sciences features LG on "Embryonic Stem Cell Research: Advances and Potential" at the Congressional Biomedical Research Caucus (7/16/2014)
The Congressional Biomedical Research Caucus (CBRC) was established in 1989 to broaden the support and knowledge of basic and clinical biomedical research issues throughout the Congress in a bipartisan manner.

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UCTV features LG on "Stem Cells and Alzheimer's Disease - On Our Mind" (7/2/2014)
Can stem cells be a weapon in the fight against Alzheimer's disease? Larry Goldstein, PhD director the the UC San Diego Stem Cell Program, joins William Mobley, MD, PhD to discuss how stem cells work and what possibilities they may unlock.

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LG featured in the Sanford Stem Cell Clinical Center YouTube Link (4/25/2014)
The Sanford Stem Cell Clinical Center at UC San Diego Health System exists to transform the enormous potential of stem cell science into real therapies for patients.

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The San Diego UNION-TRIBUNE features LG on "Sanford donates $100 million to UCSD" (11/3/2013)
Philanthropist Denny Sanford is donating $100 million to UC San Diego to speed up attempts to turn discoveries about human stem cells into drugs and therapies to treat everything from cancer and Alzheimer’s disease to spinal-cord injuries and weak hearts.

The full article on line
The San Diego UNION-TRIBUNE features LG on "Scientist to California: Fund research like a nation" (7/16/2013)
LA JOLLA — California's boosters like to compare its economic statistics to other nations. The message is that California's economy is more like a nation than a state.

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New UCSD chancellor Pradeep Khosla visits LG on his first day (8/2/2012)
Pradeep Khosla capped off his first day as UC San Diego chancellor by touring the Sanford Consortium for Regenerative Medicine, a new, state-of-the-art stem cell research facility dedicated to research and finding cures and therapies for some of society’s most devastating diseases.

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CIRM features LG on "Ask the stem cell expert: your questions answered on Alzheimer’s disease" (7/24/2012)
A few weeks ago we asked people to submit questions for the first video in our Ask the Expert series. Well, you submitted questions and we asked stem cell expert Lawrence Goldstein, PhD, at the University of California, San Diego to answer them.

The full article on line
Reuters features LG on "Programmed Cells: from Basic Neuroscience to Therapy" (4/3/2012)
"Another advantage of both induced pluripotent cells and direct reprogramming of fibroblasts to neurons is that the donor cells can come from individual patients, so the cells that are generated have the same constellation of gene polymorphisms. This is being put to good use in experiments investigating the basic mechanisms of various diseases of the nervous system, as well as testing for potential therapeutic compounds. Cells taken from patients with familial Alzheimer’s disease are being used to probe the effects of specific mutations on neuron function (Lawrence Goldstein, Howard Hughes Medical Institute, La Jolla, USA). By comparing such cells with those from patients with the non-genetic form of the disease, common disease mechanisms may be discovered."

The full article online
The Sacramento Bee features LG on “The Conversation: These cells could save lives. But when? And at what cost?” (2/12/2012)
Should California maintain its leadership in stem cell research and continue funding the California Institute for Regenerative Medicine?
"We are at a time when venture capital doesn't invest as early as it used to," said Larry Goldstein, a leading stem cell scientist at UC San Diego. "So the public has to do it. You may not like the system, but that's the system."

The full article online
News organizations feature LG on Mason's work using iPS cells to study Alzheimer's Disease (published in the journal Nature on 1/25/2012 online)
Nature News on "Alzheimer's 'in a dish' shows promise" (1/25/2012)
(Nature podcasts)
ABC News
on "Stem Cell Tech May Aid Alzheimer’s Research" (1/25/2012)
Mirror on "Scientists grow Alzheimer's cells for the first time - and hope it will prove treatment breakthrough" (1/25/2012)
Dailymail on "Hope for dementia patients after Alzheimer's cells created in lab for first time" (1/25/2012)
Express on "HOPE FOR ALZHEIMER’S CURE AS ‘DEMENTIA NERVES’ CREATED IN LAB" (1/25/2012)
UCSD News on "Researchers Induce Alzheimer’s Neurons From Pluripotent Stem Cells" (1/25/2012)

Akron News Now
on "Stem-Cell Tech May Aid Alzheimer’s Research" (1/25/2012)
Fox News on "Researchers replicate Alzheimer's disease neurons with stem cells" (1/25/2012)
KBOI on "Stem-Cell Tech May Aid Alzheimer’s Research" ( 1/25/2012)
E! Science News on "Researchers induce Alzheimer's neurons from pluripotent stem cells" (1/25/2012)
Alzheimer’s Reading Room on "Scientists Replicate Alzheimer’s Neurons Using Stem Cell Technology(1/25/2012)
The San Diego Union-TRIBUNE on "Stem cell research: no laughing matter" (1/26/2012)
HealthCanal on "Researchers Induce Alzheimer’s Neurons From Pluripotent Stem Cells" (1/26/2012)
Genetic Engineering News on "iPSC-Derived Neurons Shine New Light on Sporadic vs. Familial Alzheimer Disease" (1/26/2012)
Inventorspot on "Stem Cell Technology Used To Create Neuronal Model For Alzheimer's Disease" (1/26/2012)
News-Medical.net on "Breakthroughs in Alzheimer’s disease research" (1/26/2012)
The North County Times on "Alzheimer's brain cells grown from patients' skin cells could model disease" (1/26/2012)
Truthdive on "Stem cell-derived neurons may help find cause of Alzheimer’s" (1/26/2012)
HealthCanal on "Stem cell technology reveals clues to Alzheimer’s" (1/27/2012)
Bioscience Technology on "Researchers Induce Alzheimer’s Neurons From Pluripotent Stem Cells" (1/27/2012)
Domain-B on "Researchers induce Alzheimer's neurons from pluripotent stem cells" (1/27/2012)
Bionity on "Researchers induce Alzheimer's neurons from pluripotent stem cells" (1/27/2012)
El Indepiendte De Canarias on "Desarrollan un nuevo método para entender la causa del Alzheimer" (2/2/2012)
Nature Reviews Neuroscience on "Neurodegenerative disease: Dishing up Alzheimer's disease" (March 2012, 13:149)
Cell Stem Cell on "iPSCs to the Rescue in Alzheimer's Research" (2 March 2012, 10:235)
THE LATEST WITH features about kinesins and stem cells (12/26/2011)
Wired Science features LG on "Inside the Strange Science of Cord Blood Banking" (12/8/2011)
For parents, the details of cord blood use aren’t always clear, said Dr. Lawrence Goldstein, a University of California, San Diego cell biologist and author of Stem Cells for Dummies.

Full article on line
Yahoo! News features LG on “Scientists Clone Embryonic Stem Cells from Individuals To Aid In Cure For Diabetes” (10/8/2011)
“I think it will teach us a lot about how to control the generation of all the different cell types that we would like to study and use for therapy,” said Lawrence Goldstein, the director of the stem cell research program at the University of California at San Diego. “I think it’s a really exciting development."

The full article on line
News Organization feature LG talk on “World’s top stem cell researchers in Pasadena for conference” (10/3 -10/4/2011)
iBioMagazine features LG on "Scientific Citizenship" (9/26/2011)
Several more News Organizations feature LG on Peyton Manning's stem cell therapy (9/19/2011-9/22/2011)
Good Morning America features LG on “Peyton Manning’s Stem Cell Therapy” (9/20/2011)
The San Diego UNION-TRIBUNE features LG on "UCSD's Goldstein: Too little spent on Alzheimer's research" (9/7/2011)

We asked Lawrence Goldstein, director of the UC San Diego Stem Cell Program, to provide a bit of perspective on the amount of money being spent to find treatments for Alzheimer's disease. Goldstein, who is also a Howard Hughes Medical Institute Investigator, said:

"We are spending less than $1 billion on research from the major funding agency (National Institute of Health) to find effective treatments to try to solve a problem that is costing us trillions over the course of a few more years.

The full article on line

USA Today features LG on “Doctors offer unapproved stem cell therapies” (6/28/2011)

"We'd all love easy miracles," says Larry Goldstein, head of stem cell research at the University of California-San Diego. "That's not the way it works."
...
FDA regulations have loopholes, Goldstein says. FDA guidelines limit its authority to regulate treatments involving cells that are withdrawn from a patient and then infused the same day with only "minimal manipulation." Last August, in a test of its authority, the FDA requested an injunction from the U.S. District Court in Washington, D.C., to block a Broomfield, Colo., orthopedic clinic, Regenerative Sciences, from formulating treatments of cultured stem cells.

The full article on line

The Detroit News features LG on "Family looks to China for child's stem cell treatment" (6/7/2011)
... while stem cell research holds profound promise and is constantly advancing — the first embryonic stem cell-based treatment for acute spinal cord injuries, for example, has been authorized by the Food and Drug Administration for Phase 1 clinical trials — the only proven uses now are for bone marrow transplants and to treat some bone, skin and corneal diseases, according to the International Society for Stem Cell Research.
"After that, everything is experimental," said Larry Goldstein, director of the University of California, San Diego, Stem Cell Program.

The full article on line.
The San Diego Union Tribune features LG on "UCSD researchers find problem with stem cells grown from skin" (5/13/2011)
“This paper, if validated by others, tells us that is not true,” said Larry Goldstein, who heads the stem cell research program at UCSD but wasn’t involved in the work. “That problem will have to be solved in developing (the stem cells) for transplantation therapy.”

The full article online
News organizations feature LG for working on iPS cell mutations (published in the journal Nature on March 3, 2011)

The San Diego UNION-TRIBUNE on "San Diego researchers shed light on gene mutations in stem cells"(3/2/2011)

ScienceDaily on “Mutations Found in Human Induced Pluripotent Stem Cells“(3/2/2011)

North County TImes on "BIOTECH: More evidence of possibly dangerous mutations in artificial stem cells" (3/2/2011)

UCSD News on "Mutations Found In Human Induced Pluripotent Stem Cells" (3/2/2011)

MIT Technology Review on "Reprogrammed Stem Cells Are Rife with Mutations" (3/3/2011)

News organizations feature LG and Sandra for their work on Prion (published in the journal Cell on February 18, 2011)

UCSD News on "Unraveling How Prion Proteins Move Along Axons to the Brain" (2/17/2011)

BiomedME on "Improving Understanding Of The Spread Of Infectious Prions" (2/20/2011)

ScienceDaily on "Unraveling How Prion Proteins Move Along Axons in the Brain” (2/22/2011)

The San Diego UNION-TRIBUNE features LG on"UCSD stem cell researchers get $5.6 million from state" (1/27/2011)

At UCSD, a research team headed by Larry Goldstein received $1.8 million to continue developing a way to mass-produce active stem cells, known as induced pluripotent stem cells, from dormant stem cells found in adult human tissue.

Steady supplies of induced cells will give other researchers a faster and lower-cost way for testing new drugs for disease associated with genetic mutations, such as Alzheimer’s disease, said Goldstein, who directs the university’s stem cell program.

The full article on line

The Huffington Post features LG on "Rescuing Cognition': California Versus Alzheimer’s Disease" (1/25/2011)

One champion is Dr. Larry Goldstein at UC San Diego. If you ever have the chance to hear Larry Goldstein speak, don't miss it. He makes the research understandable, while never sugar-coating the tremendous difficulties of research for cure.

Using embryonic stem cells, he is working to develop a cellular model of Alzheimer's in a Petri dish. Think what this could mean. Right now scientists can only learn from patients when they are in the advanced stages of the disease -- their disease may have begun decades earlier -- not to mention it is unlikely for anyone to volunteer to donate a piece of their living brain.

The full article on line

The Fort Worth Star-Telegram features LG on “Couple’s search for hope leads to controversial treatment in China” (12/12/2010)

Researchers such as Dr. Lawrence Goldstein, who is on the board of the International Society for Stem Cell Research, empathize with families who are desperate for a cure. But they balance that with reality: It takes time to do research properly. Stem cell therapies have been proved effective only for blood disorders such as leukemia and some skin conditions.
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LG authors "Promise is worth the risk of stem cell agency" (The Sacramento Bee on 11/29/2010)

California's ambitious landmark stem cell research program has been criticized as a bad bet for taxpayers.

As a scientist and one of the architects of the California Institute for Regenerative Medicine, I agree that steering between an over-optimistic view of what is possible and a hyper-pessimistic commitment to inaction can be difficult. But – viewed against scientific principles, medical need, history and logic – the state's stem cell agency is a calculated but not reckless risk, and it is not merely a bet on a narrow research avenue.

Full article on line

Los Angeles Business Journal features LG on "Stem Cells Take Root in Koreatown" (11/15/2010)
Larry Goldstein, director of UC San Diego’s stem cell program and a board member of the International Society for Stem Cell Research, cautioned against unapproved medical uses of stem cells.
“Anybody can go on a street corner and declare they have a cure for anything,” he said. “Sometimes you find out there are dangers to patients that you didn’t anticipate, which emphasizes why it’s so important to do careful clinical experimentation before selling it to large numbers of people.”
Full article
CIRM TV features LG on "Lou Gehrig's Disease (ALS): Progress and Promise in Stem Cell Research" (10/29/2010)



Watch it online.

LG authors "The best birthday gift for UCSD" (San Diego Union-Tribune on 11/18/2010)
The 50th anniversary of UC San Diego invites assessment of the value of our campus to the region and to California. In particular, at a time of great fiscal stress in the state budget, when every dollar allocated and spent should be examined, we must ask whether our community and state extract appropriate value from its contribution.
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KPBS features LG on "San Diego Researchers Jarred By Stem Cell Ruling" (8/24/2010)
The San Diego UNION-TRIBUNE features LG on"Local reaction to stem cell ruling" (8/24/2010)
"The ruling is terrible news, not only for scientists trying to find therapies using human embryo stem cells, but also for people who depend on us to move as quickly as possible to find those therapies," said Larry Goldstein, who heads the stem cell research program at the University of California San Diego.
Full article
The Sacramento Bee features LG on "Beware stem cell 'cures,' doctors say" (8/8/2010)

"The world is full of clinics and pseudo practitioners who would offer 'treatments' for conditions that cannot be treated," said Larry Goldstein, director of the UC San Diego Stem Cell Program and a board member of the International Society for Stem Cell Research.
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ABC News features LG on "Stem Cell-Engineered Windpipe for Cancer Patients" (8/2/2010)
The Wall Street Journal features LG on "Universities Bank on Stem-Cell Research" (7/1/2010)
La Jolla Light features LG on “UCSD team gets $11.5 million for stem cell research on Lou Gehrig's disease” (6/29/2010)

Embracing the concept that the whole is greater than the sum of its individual parts, an $11.5 million "disease team" grant has been awarded to UC San Diego to fast track stem-cell research on Amyotrophic Lateral Sclerosis (ALS) - also known as Lou Gehrig's Disease. The goal is to advance basic research to human clinical trials within four years.

Funding is from the California Institute for Regenerative Medicine (CIRM), the state stem-cell agency created by voter passage of proposition 71. In a public meeting on June 23, local scientists, health advocates and CIRM leadership described the grant's research focus.

ALS is a progressive, fatal disease in which motor neurons, the nerve cells that control voluntary muscle contractions, simply die. Over time, ALS leads to extreme muscle weakness, paralysis, and death.

"Like most cells in the body, motor neurons do not live in isolation; they live in an environment, surrounded by other type of non-neuron cells," said Larry Goldstein, Ph.D., professor of cellular and molecular medicine at UCSD School of Medicine, Howard Hughes Medical Institute Investigator and director of the UCSD Stem Cell Program.

"Therefore, one of the ways you might image to eliminate (disease) spread would be by supporting the 'neighborhood' rather than replacing the neurons themselves."

This has led to interest in exploiting a special type of cell called an astrocyte progenitor. Astrocytes are glial cells, a family of cells that support the proper functioning and insulation of neurons. Astrocytes, in particular, help with neurotransmissions and neuronal metabolism. Previous studies indicate that transplanting healthy glial cells into patients could be a possible treatment for ALS, and animal studies have shown that astrocytes possess particular promise in this regard.

Co-principal investigators on the grant are Goldstein, Martin Marsala, M.D., professor in the UCSD School of Medicine's department of anesthesiology, and Sam Pfaff, Ph.D., a professor in the Salk Institute's Gene Expression Laboratory. They will lead researchers in studies of two methods of administering progenitors in animal models and test the safety and efficacy of these approaches, with the goal of providing proof-of-principle and laying the groundwork for clinical trials.

"Any novel treatment option would not only be clinically competitive, but could have a major impact for thousands of patients currently battling this disease," Don Cleveland, Ph.D., professor of Medicine, Neurosciences and chair of the UCSD Department of Cellular and Molecular Medicine, stated in a press release. Cleveland is also head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research based at UCSD. "This approach has the potential to lead to the development of new therapies that could significantly extend the lifespan of individuals living with this disease, and improve their quality of life."

In addition to basic research, animal data, and pre-clinical aspects of the studies, another disease-team member is Carlsbad-based Life Technologies Corp. which will provide expertise in stem-cell biology, cell separation, next-generation sequencing, and scalable bioproduction.

"The goal is to develop a clinically compliant process for preparation of human astrocyte precursors," said Mark Bonyhadi, Ph.D., director of clinical business development for cell therapy systems at Life Technologies.
Approximately 30,000 people in the United States are affected with ALS with 5,600 new cases diagnosed each year. The causes of ALS are unknown; there is no cure. Only one drug - Rilutek - is currently approved by the Food and Drug Administration for treating ALS. Rilutek extends the lifespan of ALS patients by a maximum of three months.

Resource
LG appears on CBS's 60 Minutes: "21st Century Snake Oil" (4/18/2010)

"60 Minutes" hidden cameras expose medical conmen who prey on dying victims by using pitches that capitalize on the promise of stem cells to cure almost any disease.





LG appears in Part 2. The last one is Extra (LG talks about the Promise of Stem Cell Treatment).
Read the story and comments on-line.

Stem Cell Myth Buster (This Week @ UCSD on 4/12/2010)
Research pioneer uses ‘Stem Cell for Dummies’ book to dispel misconceptions about stem cell research by Ioana Patringenaru
Read the article

The stem cellsman: Lawrence Goldstein (UT on 3/22/2010)
Lawrence Goldstein may not be the face of stem cell research, but the professor of cellular and molecular medicine at the University of California San Diego is certainly among its most vocal and staunchest advocates — and a leading researcher in the field.
Full article on line

PDF file
LG features CBS Evening News:“Where America Stands: Stem Cell Research” (3/16/2010)
Where America Stands: New Problems and Solutions as Stem Cell Research Finally Picks Up Steam.

Read the story
LG talks about mysteries of stem cells on KPBS (3/2/2010)
LG authors "Stem Cells for Dummies" (2/2/2010)
News about the book:

Stem Cells 101 in HHMI Bulletin

At UCSD bookstore, LG discusses and signs his book "Stem Cells for Dummies" on April 15 @ 12:30pm .

"UCSD researcher pens 'Stem Cells for Dummies' " by La Jolla Light (2/28/2010)


LG discusses and signs "Stem Cells for Dummies" at The Book Works (3/2/2010)


Stem Cells For Dummies: The Controvery, Pros and Cons, Facts, Future Research

Stem Cells For Dummies: Cheat Sheet

Stem Cells For Dummies: Book Information

The book is on sale at Amazon, Barnes & Noble, and other book stores.
LG Receives 2009 ASCB Public Service Award (12/06/2009)
ASCB is honoring LG for his “dedication in advocating for biomedical research funding and research policy issues around the country. During the past decade, Goldstein has spent numerous hours explaining why government funding of stem cell research is important, and sharing his expertise with members of Congress and the media to help them understand the complicated science behind stem cell legislation.”

Locally, LG has served as a national leader in stem cell research and policy, including serving as co-chair of the scientific advisory committee for the campaign to pass California's Proposition 71, a voter-endorsed measure to provide $3 billion in stem cell research funding in California. LG has also appeared on numerous occasions before the California legislature and the U.S. Congress and Senate to testify in support of stem cell research and biomedical research funding.

Video for the acceptance speech

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LG talks about California stem cell project reported on UT (11/12/2009)

As California's $3 billion stem cell program passes its fifth anniversary, the challenges remain great.

Much of San Diego's stem cell community gathered in La Jolla yesterday for the annual “Stem Cell Meeting on the Mesa,” and there was a lot of talk about big ideas and exciting experiments.

But there was also caution about not over-promising in terms of how quickly the work will pay off, and what form stem cell products will take if they do ultimately emerge.

Larry Goldstein, director of the stem cell program at the University of California San Diego, told the audience of at least 200 people that the next five years could see treatments start to emerge for a range of conditions.

But those five years will require testing various approaches to steadily improving the understanding of stem cell science. While there are a lot of promising ideas in the stem cell field, it's not clear which will work.

“This is going to be tough,” Goldstein said. “There's no sugar-coating this.”

Sources

LG talks about Obama's stem cell order on KPBS (03/09/2009)
LG was named a Fellow of the prestigious American Academy of Arts and Sciences (05/05/2008)

Seven scholars from the University of California, San Diego were recently named Fellows of the prestigious American Academy of Arts and Sciences: four from the School of Medicine, and one each from economics, anthropology and the Scripps Institution of Oceanography. The American Academy of Arts & Sciences honors the country's leaders in scholarship, business, the arts and public affairs. New members will be formally welcomed into the Academy at an Induction Ceremony in Cambridge, Massachusetts, on October 11, 2008.

The new UC San Diego fellows includes Larry Goldstein, Ph.D., professor in the Department of Cellular & Molecular Medicine at the UC San Diego School of Medicine, a Howard Hughes Medical Institute (HMMI) Investigator and director of the UC San Diego Stem Cell Program.

Source

LG talks about stem cell research reported on UT (11/08/2008)

Using an old photograph of California Gov. Arnold Schwarzenegger in his acting days as Conan the Barbarian, University of California San Diego professor Larry Goldstein explained the complex and lengthy road over which the body's neurons must transmit signals to synapses in the feet and hands, and all that could go wrong in between.

Using human embryonic stem cells, scientists in Goldstein's lab are creating human models of Alzheimer's disease to determine the role of environmental and genetic damage.

It's one disease that requires a human model, Goldstein said, because mice and other animals don't get it.

“Who can tell if a mouse is demented anyway?” Goldstein said.

Through its work, Goldstein's team learned that the best models are created by coaxing skin cells from people with Alzheimer's to go backward down the development chain until they are pluripotent, meaning they are like embryonic cells in having the capacity to evolve into many cell types. These so-called induced pluripotent cells are then coaxed to develop forward again, into diseased neurons.

Sources

LG on KUSI's "San Diego People" with Kimberly Hunt (09/02/2007)

Larry Goldstein and KUSI news anchor Kimberly Hunt discuss the basics of stem cells: How are they derived? What do they do and why are stem cells important? What diseases do scientists hope to treat or cure?

Importantly, the program covers specific stem cell research projects at UCSD, and why San Diego is one of the best places in the world for stem cell research.

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LG talks with Charlie Rose (05/16/2007)
This fifth episode of the Charlie Rose Science Series is an exploration of one of the most promising fields of science: stem cell research. Our panel discusses existing successes in the use of stem cells, such as bone marrow transplants, and the hopes for future applications of both adult and embryonic stem cells, both as a way to model and study disease and a possible treatment for a variety of conditions, such as heart and blood disease, diabetes , Parkinson's, Lou Gehrig's disease, Alzheimer's, spinal cord injuries, and cancer. The uses of federal and private funding for the research are also considered. These issues are discussed by Sir Paul Nurse, president of The Rockefeller University, Doug Melton, Co-director of the Harvard Stem Cell Institute, George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute, Larry Goldstein, director of the UC San Diego Stem Cell program, and Story Landis of the National Institute of Neurological Disorders and Stroke.

LG talks about stem Cell researchers on Ethics and Science on KPBS (04/05/2007)
LG testifies on US congress about research involving embryonic stem cells (04/26/2000)
Witnesses testified about research involving embryonic stem cells. Among the issues raised were the potential benefits of such research in treating disease, whether to renew federal funding of stem cell research, and the ethical considerations involved in conducting the research.

Video
LG talks on AAMC about stem cell research (10/24/1999)

Participants talked about the scientific and moral issues surrounding the use of embryonic stem cell research. They focused on the advances in research that could occur with the use of the stem cells. They also talked about the ethics of using embryonic stem cells and the creation of a public commission to research the issue. After their prepared remarks they answered questions from the audience.
Video