Current Lab Members (Alumni)

  • Larry Goldstein, Ph.D.
  • Ingrid Niesman, Ph.D.
  • Angels Almenar-Queralt, Ph.D.
  • Alexandria Balcer
  • Laura Cabebe
  • Andy Chen
  • Rodrigo dos Santos Chaves, Ph.D.
  • Jordan Dizon
  • Areian Eghbali
  • Lauren Fong
  • Nidhi Goyal, M.D.
  • Cheryl Herrera
  • Vanessa Langness
  • Peter Lotfy
  • Ashley Loza
  • Hasan Makda
  • Renee Marsolais
  • Paulina Ordonez, M.D.
  • Hinal Parikh
  • Liz Roberts
  • John Steele, Ph.D.
  • Tami Taketani, M.D.
  • Rik van der Kant, Ph.D.
  • Louie Wang
  • Emma Wu
  • Chao-Shun Yang, Ph.D.
  • Jessica Young, Ph.D.

Larry Goldstein, Ph.D.
Principal Investigator
Distinguished Professor, Dept. of Cellular and Molecular Medicine, and Dept. of Neurosciences
Director, UC San Diego Stem Cell Program
Scientific Director, Sanford Consortium for Regenerative Medicine
Director, Sanford Stem Cell Clinical Center
Email: lgoldstein@ucsd.edu
Tel: (858) 534-9702

Educations:
B.A., Biology and Genetics, University of California, San Diego, 1976.
Ph.D., Genetics, University of Washington, Seattle, 1980.

Member:
American Academy of Arts and Sciences

Awards:
Public service award, American Society for Cell Biology
Loeb Chair in the Natural Sciences, Harvard University
American Cancer Society Faculty Research Award
Ellison Medical Foundation Senior Scholar Award in Aging Research

Co-Founder: Cytokinetics

Ingrid Niesman, M.S., Ph.D.
Lab Administrator
Email: goldsteinadmin@ucsd.edu iniesman@ucsd.edu
Tel: (858) 534-9700

Education:

Postdoctoral Training: California Institute for Biomedical Sciences (Calibr) 2013-15
Ph.D., Cell Biology, University of Sunderland, UK 2014
M.S., Neuroscience/Microscopy, University of Illinois-Urbana, 1984
B.S., Biology, Utah State University, Logan, 1981

Research Interests:
Strong microscopy background, including advanced LM and EM analyses, with empathsis in Neuroscience and Cell Biology.

Selective Publications
1. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent.
Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH.
Anesthesiology. 2014 Sep;121(3):538-48. doi: 10.1097
2. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry.
Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP.
Behav Brain Res. 2014 Jul 1;267:6-11. doi: 10.1016/j.bbr.2014.03.014
3. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice.
Niesman IR, Schilling JM, Shapiro LA, Kellerhals SE, Bonds JA, Kleschevnikov AM, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP.
J Neuroinflammation. 2014 Mar 3;11:39. doi: 10.1186/1742-2094-11-39.
4. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia.
Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH.
Mol Cell Neurosci. 2013 Sep;56:283-97. doi: 10.1016/j.mcn.2013.07.002. Epub 2013 Jul 10.

 

Angels Almenar-Queralt, Ph.D.
Associate Project Scientist
Email: aalmenar@ucsd.edu
Tel: (858) 534-9703

Education:
Ph.D. Cell Biology-The Scripps Research Institute, La Jolla, CA/University of Barcelona, Spain.
B.S. Biology-University of Biology of Barcelona, Spain

Research Interests:
Alzheimer’s disease (AD) is the most common form of dementia, affecting more than 30 million people worldwide. To date, all attempted clinical trials have failed to slow down, stop, or revert cognitive deterioration in AD patients, perhaps because treatments are administrated when neuronal damage is already irreversible, or perhaps because lack of understanding on key underlying mechanisms leading to this disease. I am using brain samples, cerebrospinal fluid, and induced pluripotent stem cell (iPSC)-derived neurons from AD patients to identify endophenotypes that may be associated with early stages of the disease, and to understand the underlying mechanisms leading to these phenotypes. Together, I hope my findings would contribute to early AD detection and new ways of treatment.

Selected Publications:
1. Almenar-Queralt, A., Falzone, T.L., Shen, Z., Lillo, C., Killian, R.L., Arreola, A.S., Niederst, E.D., Ng, K.S., Kim, S.N., Briggs, S.P., Williams, D.S., Goldstein L.S. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. (2014). 34:3320-39.

2. Almenar-Queralt, A.*, Kim, S.N., Herrera, C.M., Benner, C., Kang, D.E., Garcia-Bassets, I., Goldstein, L.S. (*co-corresponding author). Presenilins Regulate Neurotrypsin Gene Expression and Neurotrypsin-Dependent Agrin Cleavage Via CREB Modulation. J Biol Chem. (2013). 288:35222-36

3. Killian, R.L., Flippin, J.D., Herrera, C.M., Almenar-Queralt, A.*, Goldstein, L.S.* (*co-corresponding author). Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. (2012). 7(1):e29755


View all articles by Angels Almenar-Queralt

Alexandria Balcer
M.S. student (Angels)
Email: alexandrabalcer@gmail.com
Tel: (858) 534-9703


Laura Cabebe
CIRM Bridges Intern
Email: cabebe.laura@yahoo.com
Tel: (858) 534-9703

/div>

Andy Chen
M.S. student (Angels)
Email: agc003@ucsd.edu
Tel: (858) 534-9703

Rodrigo dos Santos Chaves, Ph.D.Sandra_e
Postdoctoral Fellow
Email: rchaves@ucsd.edu
Tel: (858) 534-9703

Education:
B. S. in Biological Sciences. Methodist University of Sao Paulo, UMESP, Sao Bernardo Do Campo, Brazil, 2011.
2015 PhD in Experimental Pathophysiology. College of Medicine - University of Sao Paulo, FMUSP, Sao Paulo, Brazil

Research Interests:
My current research is focused on exploring alterations in mitochondrial transport prior to the formation of protein aggregates in the context of neurodegenerative disease; and the mechanism by which these changes in neuron physiology trigger protein aggregation and neurodegeneration.

Publications:
1. Chaves, R. S., T. Q. Melo, et al. Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci, v.11, p.144. 2010.

2. Melo, T. Q., M. D'unhao A, et al. Rotenone-Dependent Changes of Anterograde Motor Protein Expression and Mitochondrial Mobility in Brain Areas Related to Neurodegenerative Diseases. Cell Mol Neurobiol, 33(3), p.327. 2012.

3. Chaves, R. S., T. Q. Melo, et al. Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone. Acta neurobiologiae experimentalis, v73, p.541. 2013.


Jordan Dizon
M.S. SDSU (John)
Email: jordan.dizon@ymail.com
Tel: (858) 534-9703


Areian Eghbali
Research Assistant
Email: areianeghbali@gmail.com
Tel: (310) 531-6432

 

 

Lauren FongSandra_e
Biomedical Sciences Graduate Student
Email: lkfong@ucsd.edu
Tel: (858) 534-9703

Education:
B.A., Molecular and Cell Biology, UC Berkeley, 2009

Publications:
1. Soldner F, Laganiere J, Cheng AW, Hockenmeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Meyers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu J, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. (2011) Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 146 (2): 318-331.

2. Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X., Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz, KS, Forsayeth J, Zhang HS. (2010) An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease. The Journal of Neuroscience 30(49): 16469–16474.

 

Nidhi Goyal, M.D.
Clinical Fellow
Email: npandhoh@ucsd.edu
Tel: (858) 534-9703


Cheryl Herrera
Sr. Research Associate
Email: cmherrera@ucsd.edu
Tel: (858) 534-9703


Vanessa Langness
Biomedical Sciences Graduate Student
Email: vlangness@ucsd.edu
Tel: (858) 534-9703

Education:
B.S., Chemistry and Biology, Metropolitan State University of Denver, 2013

Research Interests:
I am interested in using human induced pluripotent stem cells (hIPSC) as a model to study early changes in intracellular trafficking and lipid homeostasis that occur during the pathogenesis of familial Alzheimer’s Disease.

Peter Lotfy
Lab Research Assistant
Email: plotfy@ucsd.edu
Tel: (858) 534-9703


Ashley Loza
Lab Research Assistant
Email: aloza@ucsd.edu
Tel: (858) 534-9703


Hasan Makda
Lab Research Assistant
Email: hmakda@ucsd.edu
Tel: (858) 534-9703


Renee Marsolais
CIRM Bridges Intern
Email: marso002@cougars.csusm.edu
Tel: (858) 534-9703


Paulina Ordonez, M.D.
Assistant Professor of Pediatrics
Email: pordonez@ucsd.edu
Tel: (858) 534-9703

Education:
Doctor in Medicine and Surgery- Universidad Central del Ecuador, 2002
Internship and Residency in Pediatrics- University of Colorado Health Sciences Center, 2006
Fellowship in Pediatric Gastroenterology, Hepatology and Nutrition- University of California at San Diego, 2009

Research Interests:
I am interested in using human embryonic stem cells (hESC) to create models of disease. I am involved in the study of Niemann Pick type C (NPC), a progressive and lethal pediatric dementia that shares multiple features with Alzheimer's disease. I have generated a set of hESC with decreased expression of NPC1, the gene that is mutated in patients with NPC. Neurons derived from NPC1 knockdown hESC exhibit abnormal cellular phenotypes and impaired survival when compared to wild type hESC derived neurons. We are currently exploring the contribution of these pathological phenotypes on the development of disease and the mechanisms underlying neuronal failure in NPC1 knockdown human neurons.

Hinal Parikh
Lab Research Assistant
Email: hrparikh@ucsd.edu
Tel: (858) 534-9703




Liz Roberts

Staff Research Associate
Email: lizroberts@ucsd.edu
Tel: (858) 534-9703

Educations:
M.A. in Biology (Molecular Genetics), University of Kansas, 1993
B.A. in Psychology, University of Colorado, 1984

Selected Publications:
1. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillee S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH Jr, Julien JP, Goldstein LS, Cleveland DW. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice (2003). Science 302(5642):113-7.

2. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS.           
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP (2001). Nature 414 (6864):643-8.

3. Marszalek JR, Liu X, Roberts EA, Chui D, Marth JD, Williams DS, Goldstein LS (2000). Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell 102(2):175-87.
View all articles by Liz Roberts

p>


John Steele, Ph.D.

IRACDA Postdoctoral Fellow
Email: jsteele@ucsd.edu
Tel: (858) 534-9703

Education:
B.A., Psychology, Kenyon College Gambier, 2007
Ph.D., Neuroscience, Mount Sinai School of Medicine, 2011
Postdoc, Neurobiology, Rockefeller University

Selected Publications:

1. Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer’s disease mouse model. J Comp Neurol 2014 Jan 11; [Epub ahead of print].

 

2. Lane RF, Steele JW, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer’s amyloid-beta. J Neurosci 2013 Apr 17; 33(16): 7099-7107.

 

3. Steele JW and Gandy S. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model. Autophagy 2013 April; 9(4): 1-2.

 

View all articles by John Steele


Tami Taketani, M.D.
Clinical Fellow
Email: ttaketani@ucsd.edu
Tel: (858) 534-9703


Rik van der Kant, Ph.D.
Postdoctoral Researcher
Email: rvanderkant@ucsd.edu
Tel: (858) 534-9703

Education:

PhD in Cell Biology Netherlands Cancer Institute, Amsterdam; 2013

M.A. in Biology Radboud University Nijmegen; 2007

B.A. in Biology Radboud University Nijmegen; 2005

Selected Publications:

1. Rik van der Kant, Alexander Fish, Lennert Janssen, Hans Janssen, Sabine Krom, Nataschja Ho, Thijn Brummelkamp, Jan Carette, Nuno Rocha, Jacques Neefjes, Late endosomal transport and tethering are coupled processes and the cholesterol sensor ORP1L. J Cell Science, 2013 Aug 1;126(Pt 15):3462-74. PMID: 23729732

2. Rik van der Kant, Ilse Zondervan, Lennert Janssen, Jacques Neefjes, Cholesterol binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1. J Lipid Research, 2013 Aug;54(8):2153-65. PMID: 23709693

3. Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012 Jan 20. PMID: 22261744

 





Louie Wang

Undergraduate Assistant (Vanessa)
Email: lowang@ucsd.edu
Tel: (858) 534-9703














Emma Wu
Lab Research Assistant
Email: eywu@ucsd.edu
Tel: (858) 534-9703




Chao-Shun Yang, Ph.D.
Postdoctoral Researcher
Email: chy095@ucsd.edu
Tel: (858) 534-9703


Jessica Young, Ph.D.
Assistant Project Scientist
Email: jeyoung@ucsd.edu
Tel: (858) 534-9703

Education:
B.S. University of Wyoming, 1997
M.A. Sonoma State University, 2002
Ph.D. University of Washington, 2009


Research Interests:
1. Using human inducible pluripotent stem cells to develop neuronal models of Alzheimer’s disease (AD).
2.  Examining genetic polymorphisms that predispose individuals to sporadic AD.
3.  Using Zinc Finger Nuclease (ZFN) technology to target genes involved in both sporadic and familial AD.

Selected Publications:
1. Young JE and La Spada AR.  Development of selective nutrient deprivation as a system to study autophagy induction and regulation in neurons. Autophagy 2009.  May 16; 5(4): 555-57.
2. Young JE, Garden GA, Martinez R, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, and La Spada AR.  Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by JNK, c-Jun, and DP5/HRK.  J Neurosci. 2009. Feb 19; 29(7): 1987-97.
Young JE, Martinez RA, and La Spada AR.  Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.  J Biol Chem.  2009 Jan 23; 284(4): 2263-73.
4. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
J Biol Chem. 2007 Oct 12;282(41):30150-60.

View all articles by Jessica Young