Current Lab Members (Alumni)

  • Larry Goldstein, Ph.D.
  • Mieko Ueno, Ph.D.
  • Ruth Padrón
  • Angels Almenar-Queralt, Ph.D.
  • Jordan Dizon
  • Mariah Dunlap
  • Rodrigo dos Santos Chaves
  • Lauren Fong
  • Nidhi Goyal, M.D.
  • Cheryl Herrera
  • Vanessa Langness
  • Peter Lotfy
  • Hasan Makda
  • Haruna Nakajima
  • Anthony Nguyen
  • Paulina Ordonez, M.D.
  • Hinal Parikh
  • Nisha Parmeshwar
  • Da'Kandryia Peters
  • Sol M Reyna
  • Liz Roberts
  • John Steele, Ph.D.
  • Tami Taketani, M.D.
  • Rik van der Kant, Ph.D.
  • Grace Woodruff
  • Max Yang
  • Jessica Young, Ph.D.

Larry Goldstein, Ph.D.
Principal Investigator
Distinguished Professor, Dept. of Cellular and Molecular Medicine, and Dept. of Neurosciences
Director, UC San Diego Stem Cell Program
Scientific Director, Sanford Consortium for Regenerative Medicine
Director, Sanford Stem Cell Clinical Center
Email: lgoldstein@ucsd.edu
Tel: (858) 534-9702

Educations:
B.A., Biology and Genetics, University of California, San Diego, 1976.
Ph.D., Genetics, University of Washington, Seattle, 1980.

Member:
American Academy of Arts and Sciences

Awards:
Public service award, American Society for Cell Biology
Loeb Chair in the Natural Sciences, Harvard University
American Cancer Society Faculty Research Award
Ellison Medical Foundation Senior Scholar Award in Aging Research

Co-Founder: Cytokinetics

Mieko Ueno(植野美枝子), Ph.D.
Lab Manager
Email: goldsteinadmin@ucsd.edu
Tel: (858) 534-9700

Education:
Ph.D., Linguistics and Cognitive Science, University of California, San Diego, 2003
M.A., Linguistics, University of Michigan, Ann Arbor, 1997
B.A., Political Science, University of Michigan, Ann Arbor, 1990

Ruth Padrón
Laboratory Administrative Assistant
Email: rpadron@ucsd.edu
Tel: (858) 822-3460

Angels Almenar-Queralt, Ph.D.
Associate Project Scientist
Email: aalmenar@ucsd.edu
Tel: (858) 534-9703

Education:
Ph.D. Cell Biology-The Scripps Research Institute, La Jolla, CA/University of Barcelona, Spain.
B.S. Biology-University of Biology of Barcelona, Spain

Research Interests:
Alzheimer’s disease (AD) is the most common form of dementia, affecting more than 30 million people worldwide. To date, all attempted clinical trials have failed to slow down, stop, or revert cognitive deterioration in AD patients, perhaps because treatments are administrated when neuronal damage is already irreversible, or perhaps because lack of understanding on key underlying mechanisms leading to this disease. I am using brain samples, cerebrospinal fluid, and induced pluripotent stem cell (iPSC)-derived neurons from AD patients to identify endophenotypes that may be associated with early stages of the disease, and to understand the underlying mechanisms leading to these phenotypes. Together, I hope my findings would contribute to early AD detection and new ways of treatment.

Selected Publications:
1. Almenar-Queralt, A., Falzone, T.L., Shen, Z., Lillo, C., Killian, R.L., Arreola, A.S., Niederst, E.D., Ng, K.S., Kim, S.N., Briggs, S.P., Williams, D.S., Goldstein L.S. UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport. J Neurosci. (2014). 34:3320-39.

2. Almenar-Queralt, A.*, Kim, S.N., Herrera, C.M., Benner, C., Kang, D.E., Garcia-Bassets, I., Goldstein, L.S. (*co-corresponding author). Presenilins Regulate Neurotrypsin Gene Expression and Neurotrypsin-Dependent Agrin Cleavage Via CREB Modulation. J Biol Chem. (2013). 288:35222-36

3. Killian, R.L., Flippin, J.D., Herrera, C.M., Almenar-Queralt, A.*, Goldstein, L.S.* (*co-corresponding author). Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism. PLoS One. (2012). 7(1):e29755


View all articles by Angels Almenar-Queralt

Jordan Dizon
SDSU CIRM Intern/Graduate Student
Email: jordan.dizon@ymail.com
Tel: (858) 534-9703


Mariah Dunlap
Lab Research Assistant
Email: mdunlap@ucsd.edu
Tel: (858) 534-9703


Rodrigo dos Santos ChavesSandra_e
International Research Scholar
Email: rchaves@ucsd.edu
Tel: (858) 534-9703

Education:
B. S. in Biological Sciences. Methodist University of Sao Paulo, UMESP, Sao Bernardo Do Campo, Brazil, 2011.
Currently pursuing PhD in Experimental Pathophysiology. College of Medicine - University of Sao Paulo, FMUSP, Sao Paulo, Brazil

Research Interests:
My current research is focused on exploring alterations in mitochondrial transport prior to the formation of protein aggregates in the context of neurodegenerative disease; and the mechanism by which these changes in neuron physiology trigger protein aggregation and neurodegeneration.

Publications:
1. Chaves, R. S., T. Q. Melo, et al. Protein aggregation containing beta-amyloid, alpha-synuclein and hyperphosphorylated tau in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci, v.11, p.144. 2010.

2. Melo, T. Q., M. D'unhao A, et al. Rotenone-Dependent Changes of Anterograde Motor Protein Expression and Mitochondrial Mobility in Brain Areas Related to Neurodegenerative Diseases. Cell Mol Neurobiol, 33(3), p.327. 2012.

3. Chaves, R. S., T. Q. Melo, et al. Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone. Acta neurobiologiae experimentalis, v73, p.541. 2013.

Lauren FongSandra_e
Biomedical Sciences Graduate Student
Email: lkfong@ucsd.edu
Tel: (858) 534-9703

Education:
B.A., Molecular and Cell Biology, UC Berkeley, 2009

Publications:
1. Soldner F, Laganiere J, Cheng AW, Hockenmeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Meyers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu J, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R. (2011) Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 146 (2): 318-331.

2. Laganiere J, Kells AP, Lai JT, Guschin D, Paschon DE, Meng X., Fong LK, Yu Q, Rebar EJ, Gregory PD, Bankiewicz, KS, Forsayeth J, Zhang HS. (2010) An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease. The Journal of Neuroscience 30(49): 16469–16474.

 

Nidhi Goyal, M.D.
Clinical Fellow
Email: npandhoh@ucsd.edu
Tel: (858) 534-9703


Cheryl Herrera
Sr. Research Associate
Email: cmherrera@ucsd.edu
Tel: (858) 534-9703


Vanessa Langness
Biomedical Sciences Graduate Student
Email: vlangness@ucsd.edu
Tel: (858) 534-9703

Education:
B.S., Chemistry and Biology, Metropolitan State University of Denver, 2013

Research Interests:
I am interested in using human induced pluripotent stem cells (hIPSC) as a model to study early changes in intracellular trafficking and lipid homeostasis that occur during the pathogenesis of familial Alzheimer’s Disease.

Peter Lotfy
Lab Research Assistant
Email: plotfy@ucsd.edu
Tel: (858) 534-9703


Hasan Makda
Lab Research Assistant
Email: hmakda@ucsd.edu
Tel: (858) 534-9703


Haruna Nakajima
Lab Research Assistant
Email: hanakaji@ucsd.edu
Tel: (858) 534-9703



Anthony Nguyen

Lab Research Assistant
UCSD Undergraduate

Email: ahn025@ucsd.edu
Tel: (858) 534-9703



Paulina Ordonez, M.D.
Assistant Professor of Pediatrics
Email: pordonez@ucsd.edu
Tel: (858) 534-9703

Education:
Doctor in Medicine and Surgery- Universidad Central del Ecuador, 2002
Internship and Residency in Pediatrics- University of Colorado Health Sciences Center, 2006
Fellowship in Pediatric Gastroenterology, Hepatology and Nutrition- University of California at San Diego, 2009

Research Interests:
I am interested in using human embryonic stem cells (hESC) to create models of disease. I am involved in the study of Niemann Pick type C (NPC), a progressive and lethal pediatric dementia that shares multiple features with Alzheimer's disease. I have generated a set of hESC with decreased expression of NPC1, the gene that is mutated in patients with NPC. Neurons derived from NPC1 knockdown hESC exhibit abnormal cellular phenotypes and impaired survival when compared to wild type hESC derived neurons. We are currently exploring the contribution of these pathological phenotypes on the development of disease and the mechanisms underlying neuronal failure in NPC1 knockdown human neurons.

Hinal Parikh
Lab Research Assistant
UCSD Undergraduate

Email: hrparikh@ucsd.edu
Tel: (858) 534-9703




Nisha Parmeshwar
Lab Research Assistant
UCSD Medical Scholar
Email: nparmesh@ucsd.edu
Tel: (858) 534-9703



Da'Kandryia Peters

Staff Research Associate
Email: dpeters.smiles@gmail.com
Tel: (858) 534-9703



Sol M. Reyna

Graduate Student in BMS
Email: sreyna@ucsd.edu
Tel: (858) 534-9703

Education:
B.S., Brown University, 2009

Research Interests:

Alzheimer’s Disease (AD) is a devastating neurodegenerative disease that currently affects more than 26 million people worldwide and is predicted to quadruple in prevalence by the year 2050. Strongly genetic forms of Alzheimer's Disease, or familial AD (FAD), are associated with mutations in the amyloid-b protein precursor (APP) or presenilin genes (PS1 and PS2), which have been implicated in a variety of diverse cellular processes including endocytosis, transcytosis, sorting, and axonal transport. I am interested in studying the role of impaired endocytosis and axonal transport in hIPSCs-derived neurons from FAD mutations.

 


Liz Roberts

Staff Research Associate
Email: lizroberts@ucsd.edu
Tel: (858) 534-9703

Educations:
M.A. in Biology (Molecular Genetics), University of Kansas, 1993
B.A. in Psychology, University of Colorado, 1984

Selected Publications:
1. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillee S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH Jr, Julien JP, Goldstein LS, Cleveland DW. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice (2003). Science 302(5642):113-7.

2. Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS.           
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP (2001). Nature 414 (6864):643-8.

3. Marszalek JR, Liu X, Roberts EA, Chui D, Marth JD, Williams DS, Goldstein LS (2000). Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors. Cell 102(2):175-87.
View all articles by Liz Roberts


John Steele, Ph.D.

IRACDA Postdoctoral Fellow
Email: jsteele@ucsd.edu
Tel: (858) 534-9703

Education:
B.A., Psychology, Kenyon College Gambier, 2007
Ph.D., Neuroscience, Mount Sinai School of Medicine, 2011
Postdoc, Neurobiology, Rockefeller University

Selected Publications:

1. Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer’s disease mouse model. J Comp Neurol 2014 Jan 11; [Epub ahead of print].

 

2. Lane RF, Steele JW, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer’s amyloid-beta. J Neurosci 2013 Apr 17; 33(16): 7099-7107.

 

3. Steele JW and Gandy S. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model. Autophagy 2013 April; 9(4): 1-2.

 

View all articles by John Steele


Tami Taketani, M.D.
Clinical Fellow
Email: ttaketani@ucsd.edu
Tel: (858) 534-9703


Rik van der Kant, Ph.D.
Postdoctoral Researcher
Email: rvanderkant@ucsd.edu
Tel: (858) 534-9703

Education:

PhD in Cell Biology Netherlands Cancer Institute, Amsterdam; 2013

M.A. in Biology Radboud University Nijmegen; 2007

B.A. in Biology Radboud University Nijmegen; 2005

Selected Publications:

1. Rik van der Kant, Alexander Fish, Lennert Janssen, Hans Janssen, Sabine Krom, Nataschja Ho, Thijn Brummelkamp, Jan Carette, Nuno Rocha, Jacques Neefjes, Late endosomal transport and tethering are coupled processes and the cholesterol sensor ORP1L. J Cell Science, 2013 Aug 1;126(Pt 15):3462-74. PMID: 23729732

2. Rik van der Kant, Ilse Zondervan, Lennert Janssen, Jacques Neefjes, Cholesterol binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1. J Lipid Research, 2013 Aug;54(8):2153-65. PMID: 23709693

3. Uusi-Rauva K, Kyttälä A, van der Kant R, Vesa J, Tanhuanpää K, Neefjes J, Olkkonen VM, Jalanko A. Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments. Cell Mol Life Sci. 2012 Jan 20. PMID: 22261744

 





Grace Woodruff

Graduate Student in Biomedical Sciences Ph.D. Program
Email: gwoodruff@ucsd.edu
Tel: (858) 534-9703

Education:
B.S. Neurobiology, University of Washington, 2009

Research Interests:
I am using human induced pluripotent stem cells (hIPSC) to innvestigate how genomic variants in individuals with Sporadic Alzheimer's Disease (SAD) contribute to the development of Alzheimer's Disease (AD).

Publications:
1. Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci. 2010 Aug;13(8):951-7

2. Sexton M, Woodruff G, Cudaback E, Kreitzer FR, Xu C, Lin YH, Möller T, Bai M, Manning HC, Bornhop D, Stella N. Binding of NIR-conPK and NIR-6T to astrocytomas and microglial cells: evidence for a protein related to TSPO. PLoS One. 2009 Dec 18;4(12):e8271



Max Yang
Lab Research Assistant
Email: m2yang@ucsd.edu
Tel: (858) 534-9703



Jessica Young, Ph.D.
BrightFocus Postdoctoral Fellow
Email: jeyoung@ucsd.edu
Tel: (858) 534-9703

Education:
B.S. University of Wyoming, 1997
M.A. Sonoma State University, 2002
Ph.D. University of Washington, 2009


Research Interests:
1. Using human inducible pluripotent stem cells to develop neuronal models of Alzheimer’s disease (AD).
2.  Examining genetic polymorphisms that predispose individuals to sporadic AD.
3.  Using Zinc Finger Nuclease (ZFN) technology to target genes involved in both sporadic and familial AD.

Selected Publications:
1. Young JE and La Spada AR.  Development of selective nutrient deprivation as a system to study autophagy induction and regulation in neurons. Autophagy 2009.  May 16; 5(4): 555-57.
2. Young JE, Garden GA, Martinez R, Tanaka F, Sandoval CM, Smith AC, Sopher BL, Lin A, Fischbeck KH, Ellerby LM, Morrison RS, and La Spada AR.  Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by JNK, c-Jun, and DP5/HRK.  J Neurosci. 2009. Feb 19; 29(7): 1987-97.
Young JE, Martinez RA, and La Spada AR.  Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.  J Biol Chem.  2009 Jan 23; 284(4): 2263-73.
4. Young JE, Gouw L, Propp S, Sopher BL, Taylor J, Lin A, Hermel E, Logvinova A, Chen SF, Chen S, Bredesen DE, Truant R, Ptacek LJ, La Spada AR, Ellerby LM. Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.
J Biol Chem. 2007 Oct 12;282(41):30150-60.

View all articles by Jessica Young