All Publications

2022

Lu S, Hu J, Arogundade OA, Goginashvili A, Vazquez-Sanchez S, Diedrich JK, Gu J, Blum J, Oung S, Ye Q, Yu H, Ravits J, Liu C, Yates JR 3rd, Cleveland DW. Heat-shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition. Nat Cell Biol. 2022 Sep;24(9):1378-1393. DOI: 10.1038/s41556-022-00988-8. Epub 2022 Sep 8. PMID: 36075972; PMCID: PMC9872726.

Jambeau M, Meyer KD, Hruska-Plochan M, Tabet R, Lee CZ, Ray-Soni A, Aguilar C, Savage K, Mishra N, Cavegn N, Borter P, Lin CC, Jansen-West KR, Jiang J, Freyermuth F, Li N, De Rossi P, Pérez-Berlanga M, Jiang X, Daughrity LM, Pereira J, Narayanan S, Gu Y, Dhokai S, Dalkilic-Liddle I, Maniecka Z, Weber J, Workman M, McAlonis-Downes M, Berezovski E, Zhang YJ, Berry J, Wainger BJ, Kankel MW, Rushe M, Hock C, Nitsch RM, Cleveland DW, Petrucelli L, Gendron TF, Montrasio F, Grimm J, Polymenidou M, Lagier-Tourenne C. Comprehensive evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9orf72 disease. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2123487119. DOI: 10.1073/pnas.2123487119. Epub 2022 Dec 1. PMID: 36454749; PMCID: PMC9894253.

Jone Lopez-Erauskin, Mariana Bravo-Hernandez, Maximiliano Presa, Michael W. Baughn, Ze’ev Melamed, Melinda S. Beccari, Ana Rita Agra de Almeida Quadros, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I. Sandra Ndayambaje, Olatz Arnold-Garcia, Melissa McAlonis-Downes, Larissa Cabrera, Jonathan W. Artates, Jennifer Ryan, Frank Bennett, Paymaan Jafar-nejad, Frank Rigo, Martin Marsala, Cathleen M. Lutz, Don W. Cleveland, Clotilde Lagier-Tourenne. Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation. bioRxiv 2022.12.11.519794; DOI: https://doi.org/10.1101/2022.12.11.519794

Pantazis CB, Yang A, Lara E, McDonough JA, Blauwendraat C, Peng L, Oguro H, Kanaujiya J, Zou J, Sebesta D, Pratt G, Cross E, Blockwick J, Buxton P, Kinner-Bibeau L, Medura C, Tompkins C, Hughes S, Santiana M, Faghri F, Nalls MA, Vitale D, Ballard S, Qi YA, Ramos DM, Anderson KM, Stadler J, Narayan P, Papademetriou J, Reilly L, Nelson MP, Aggarwal S, Rosen LU, Kirwan P, Pisupati V, Coon SL, Scholz SW, Priebe T, Öttl M, Dong J, Meijer M, Janssen LJM, Lourenco VS, van der Kant R, Crusius D, Paquet D, Raulin AC, Bu G, Held A, Wainger BJ, Gabriele RMC, Casey JM, Wray S, Abu-Bonsrah D, Parish CL, Beccari MS, Cleveland DW, Li E, Rose IVL, Kampmann M, Calatayud Aristoy C, Verstreken P, Heinrich L, Chen MY, Schüle B, Dou D, Holzbaur ELF, Zanellati MC, Basundra R, Deshmukh M, Cohen S, Khanna R, Raman M, Nevin ZS, Matia M, Van Lent J, Timmerman V, Conklin BR, Johnson Chase K, Zhang K, Funes S, Bosco DA, Erlebach L, Welzer M, Kronenberg-Versteeg D, Lyu G, Arenas E, Coccia E, Sarrafha L, Ahfeldt T, Marioni JC, Skarnes WC, Cookson MR, Ward ME, Merkle FT. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022 Dec 1;29(12):1685-1702.e22. DOI: 10.1016/j.stem.2022.11.004. PMID: 36459969; PMCID: PMC9782786.

2021

Diaz-Garcia S, Ko VI, Vazquez-Sanchez S, Chia R, Arogundade OA, Rodriguez MJ, Traynor BJ, Cleveland D, Ravits J. Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol. 2021 Dec;142(6):985-1001. DOI: 10.1007/s00401-021-02374-4. Epub 2021 Oct 7. PMID: 34618203; PMCID: PMC8568872.

Sanjuan-Ruiz I, Govea-Perez N, McAlonis-Downes M, Dieterle S, Megat S, Dirrig-Grosch S, Picchiarelli G, Piol D, Zhu Q, Myers B, Lee CZ, Cleveland DW, Lagier-Tourenne C, Da Cruz S, Dupuis L. Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation. Mol Neurodegener. 2021 Sep 6;16(1):61. DOI: 10.1186/s13024-021-00477-w. PMID: 34488813; PMCID: PMC8419956.

Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci. 2021 Aug;24(8):1089-1099. DOI: 10.1038/s41593-021-00864-y. Epub 2021 Jun 3. PMID: 34083786; PMCID: PMC8338913.

Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev. 2021 Aug 1;35(15-16):1093-1108. DOI: 10.1101/gad.348319.121. Epub 2021 Jul 15. PMID: 34266887; PMCID: PMC8336898.

Krupina K, Goginashvili A, Cleveland DW. Causes and consequences of micronuclei. Curr Opin Cell Biol. 2021 Jun;70:91-99. DOI: 10.1016/j.ceb.2021.01.004. Epub 2021 Feb 18. PMID: 33610905; PMCID: PMC8119331.

William WN Jr, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2022655118. DOI: 10.1073/pnas.2022655118. PMID: 33952700; PMCID: PMC8126856.

Theunissen F, Anderton RS, Mastaglia FL, Flynn LL, Winter SJ, James I, Bedlack R, Hodgetts S, Fletcher S, Wilton SD, Laing NG, MacShane M, Needham M, Saunders A, Mackay-Sim A, Melamed Z, Ravits J, Cleveland DW, Akkari PA. Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype. Front Aging Neurosci. 2021 Mar 26;13:658226. DOI: 10.3389/fnagi.2021.658226. PMID: 33841129; PMCID: PMC8033025.

Shan Lu, Qiaozhen Ye, Digvijay Singh, Yong Cao, Jolene K. Diedrich, John R. Yates III, Elizabeth Villa, Don W. Cleveland & Kevin D. Corbett (2021). The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nature Communications 12(1):502 PMID: 33479198, PMCID: PMC7820290, DOI: 10.1038/s41467-020-20768-y

2020

Yu H, Lu S, Gasior K, Singh D, Vazquez-Sanchez S, Tapia O, Toprani D, Beccari MS, Yates JR 3rd, Da Cruz S, Newby JM, Lafarga M, Gladfelter AS, Villa E, Cleveland DW. HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. Science. 2021 Feb 5; 371(6529):eabb4309. DOI: 10.1126/science.abb4309. Epub 2020 Dec 17. PMID: 33335017; PMCID: PMC8286096

Mariana Bravo-Hernandez , Takahiro Tadokoro , Michael R. Navarro, Oleksandr Platoshyn, Yoshiomi Kobayashi, Silvia Marsala, Atsushi Miyanohara, Stefan Juhas, Jana Juhasova, Helena Skalnikova , Zoltan Tomori , Ivo Vanicky, Hana Studenovska , Vladimir Proks , PeiXi Chen , Noe Govea-Perez, Dara Ditsworth, Joseph D. Ciacci , Shang Gao, Wenlian Zhu, Eric T. Ahrens, Shawn P. Driscoll, Thomas D. Glenn, Melissa McAlonis-Downes, Sandrine Da Cruz, Samuel L. Pfaff, Brian K. Kaspar, Don W. Cleveland and Martin Marsala (2020). Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS. Nat Med. 26(1)118-130 PMID: 31873312, PMCID: PMC8171115, DOI: 10.1038/s41591-019-0674-1

Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland & Xiang-Dong Fu (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582(7813)550-556 PMID: 32581380, PMCID: PMC7521455, DOI: 10.1038/s41586-020-2388-4

Ofer Shoshani, Simon F. Brunner, Rona Yaeger, Peter Ly, Yael Nechemia-Arbely, Dong Hyun Kim, Rongxin Fang, Guillaume A. Castillon, Miao Yu, Julia S. Z. Li, Ying Sun, Mark H. Ellisman, Bing Ren, Peter J. Campbell & Don W. Cleveland (2020). Chromothripsis drives the evolution of gene amplification in cancer. Nature 591(7848):137-141 PMID: 33361815, PMCID: PMC7933129, DOI: 10.1038/s41586-020-03064-z

Ofer Shoshani and Don W. Cleveland (2020). Gene expression regulated by RNA stability. Science 367(6473):29 PMID: 31896707, DOI: 10.1126/science.aba0713

Qiang Zhu, Jie Jiang, Tania F. Gendron , Melissa McAlonis-Downes, Lulin Jiang, Amy Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, Maria J. Rodriguez, Patrick King, Yongjie Zhang, Albert R. La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier-Tourenne and Don W. Cleveland (2020). Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nat Neurosci 23(5):615-624 PMID: 32284607, PMCID: PMC7384305, DOI: 10.1038/s41593-020-0619-5

Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis. Acta Neuropathol. 2021 12; 142(6):985-1001. Diaz-Garcia S, Ko VI, Vazquez-Sanchez S, Chia R, Arogundade OA, Rodriguez MJ, Traynor BJ, Cleveland D, Ravits J. PMID: 34618203, PMCID: PMC8568872

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation. Mol Neurodegener. 2021 09 06; 16(1):61. Sanjuan-Ruiz I, Govea-Perez N, McAlonis-Downes M, Dieterle S, Megat S, Dirrig-Grosch S, Picchiarelli G, Piol D, Zhu Q, Myers B, Lee CZ, Cleveland DW, Lagier-Tourenne C, Da Cruz S, Dupuis L. PMID: 34488813, PMCID: PMC8419956

Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genes Dev. 2021 08 01; 35(15-16):1093-1108. Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. PMID: 34266887, PMCID: PMC8336898

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB. Nat Neurosci. 2021 08; 24(8):1089-1099. Maimon R, Chillon-Marinas C, Snethlage CE, Singhal SM, McAlonis-Downes M, Ling K, Rigo F, Bennett CF, Da Cruz S, Hnasko TS, Muotri AR, Cleveland DW. PMID: 34083786, PMCID: PMC8338913

Immune evasion in HPV- head and neck precancer-cancer transition is driven by an aneuploid switch involving chromosome 9p loss. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). William WN, Zhao X, Bianchi JJ, Lin HY, Cheng P, Lee JJ, Carter H, Alexandrov LB, Abraham JP, Spetzler DB, Dubinett SM, Cleveland DW, Cavenee W, Davoli T, Lippman SM. PMID: 33952700, PMCID: PMC8126856

Novel STMN2 Variant Linked to Amyotrophic Lateral Sclerosis Risk and Clinical Phenotype. Front Aging Neurosci. 2021; 13:658226. Theunissen F, Anderton RS, Mastaglia FL, Flynn LL, Winter SJ, James I, Bedlack R, Hodgetts S, Fletcher S, Wilton SD, Laing NG, MacShane M, Needham M, Saunders A, Mackay-Sim A, Melamed Z, Ravits J, Cleveland DW, Akkari PA. PMID: 33841129, PMCID: PMC8033025

Publisher Correction: Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 Mar; 591(7850):E19. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33649505.

Causes and consequences of micronuclei. Curr Opin Cell Biol. 2021 06; 70:91-99. Krupina K, Goginashvili A, Cleveland DW. PMID: 33610905, PMCID: PMC8119331

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein. Nat Commun. 2021 01 21; 12(1):502. Lu S, Ye Q, Singh D, Cao Y, Diedrich JK, Yates JR, Villa E, Cleveland DW, Corbett KD. PMID: 33479198, PMCID: PMC7820290

Chromothripsis drives the evolution of gene amplification in cancer. Nature. 2021 03; 591(7848):137-141. Shoshani O, Brunner SF, Yaeger R, Ly P, Nechemia-Arbely Y, Kim DH, Fang R, Castillon GA, Yu M, Li JSZ, Sun Y, Ellisman MH, Ren B, Campbell PJ, Cleveland DW. PMID: 33361815, PMCID: PMC7933129

2019

Peter Ly, Simon F. Brunner, Ofer Shoshani, Dong Hyun Kim, Weijie Lan, Tatyana Pyntikova, Adrienne M. Flanagan, Sam Behjati, David C. Page, Peter J. Campbell and Don W. Cleveland (2019). Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements. Nature Genetics 51, 705-715 (2019) PMID: 30833795, PMCID: PMC6441390, DOI: 10.1038/s41588-019-0360-8

Ze’ev Melamed, Jone López-Erauskin, Michael W. Baughn, Ouyang Zhang, Kevin Drenner, Ying Sun, Fernande Freyermuth, Moira A. McMahon, Melinda S. Beccari, Jon W. Artates, Takuya Ohkubo, Maria Rodriguez, Nianwei Lin, Dongmei Wu, C. Frank Bennett, Frank Rigo, Sandrine Da Cruz, John Ravits, Clotilde Lagier-Tourenne and Don W. Cleveland (2019). Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nature Neuroscience 22, 180-190 (2019) PMID: 30643298, PMCID: PMC6348009, DOI: 10.1038/s41593-018-0293-z

Viviana Barra, Glennis A. Logsdon, Andrea Scelfo, Sebastian Hoffmann, Solène Hervé, Aaron Aslanian, Yael Nechemia-Arbely, Don W. Cleveland, Ben E. Black & Daniele Fachinetti (2019). Phosphorylation of CENP-A on serine 7 does not control centromere function. Nature Communications 10, Article number: 175(2019) PMID: 30635586, PMCID: PMC6329807, DOI: 10.1038/s41467-018-08073-1

Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland (2019). Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. eLife 2019;8:e40811 PMID: 30747709, PMCID: PMC6389288, DOI: 10.7554/eLife.40811

Fatima Gasset-Rosa, Shan Lu, Haiyang Yu, Cong Chen, Ze’ev Melamed, Lin Guo, James Shorter, Sandrine Da Cruz, and Don W. Cleveland (2019). Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron Volume 102, Issue 2, 17 April 2019, Pages 339-357.e7 PMID: 30853299, PMCID: PMC6548321, DOI: 10.1016/j.neuron.2019.02.038

2018

Jone Lopez-Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, Joshua N. Asiaban, Jonathan Artates, Anh T. Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Melanie Jambeau, Jihane Boubaker, Deborah Swing, Jinsong Qiu, Geoffrey G. Hicks, Zhengyu Ouyang, Xiang-Dong Fu, Lino Tessarollo, Shuo-Chien Ling, Philippe A. Parone, Christopher E. Shaw, Martin Marsala, Clotilde Lagier-Tourenne, Don W. Cleveland, and Sandrine Da Cruz (2018). ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS. Neuron Volume 100, Issue 4, 21 November 2018, Pages 816-830.e PMID: 30344044, PMCID: PMC6277851, DOI: 10.1016/j.neuron.2018.09.044

Dong Hyun Kim, Joo Seok Han, Peter Ly, Qiaozhen Ye, Moira A. McMahon, Kyungjae Myung, Kevin D. Corbett & Don W. Cleveland (2018). TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nat Commun. 2018 10 19; 9(1):435 PMID: 30341343, PMCID: PMC6195577, DOI: 10.1038/s41467-018-06774-1

Craig L. Bennett, Somasish G. Dastidar, Shuo-Chien Ling, Bilal Malik, Travis Ashe, Mandheer Wadhwa, Derek B. Miller, Changwoo Lee, Matthew B. Mitchell, Michael A. van Es, Christopher Grunseich, Yingzhang Chen, Bryce L. Sopher, Linda Greensmith, Don W. Cleveland, Albert R. La Spada (2018). Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients. Acta Neuropathologica (2018) 136:425–44 PMID: 29725819, PMCID: PMC6098723, DOI: 10.1007/s00401-018-1852-9

Haiyang Yu and Don W. Cleveland (2018). Tuning Apoptosis and Neuroinflammation: TBK1 Restrains RIPK1. Cell Volume 174, Issue 6, 6 September 2018, Pages 1339-1341 PMID: 30193106, DOI: 10.1016/j.cell.2018.08.035

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe’er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, and Cantley LC (2018). Chromosomal instability drives metastasis through a cytosolic DNA response. Nature (2018) 553, 467-47 PMID: 29342134, PMCID: PMC5785464, DOI: 10.1038/nature25432

Weiwei Cheng, Shaopeng Wang, Alexander A. Mestre, Chenglai Fu, Andres Makarem, Fengfan Xian, Lindsey R. Hayes, Rodrigo Lopez-Gonzalez, Kevin Drenner, Jie Jiang, Don W. Cleveland & Shuying Sun (2018). C9ORF72 GGGGCC repeat-associated non-AUG translation is upregulated by stress through eIF2a phosphorylation. Nature Communications (2018) 9:5 PMID: 29302060, PMCID: PMC5754368, DOI: 10.1038/s41467-017-02495-z

Nikita Gudimchuk, Ekaterina V. Tarasovetc, Vadim Mustyatsa, Alexei L. Drobyshev, Benjamin Vitre, Don W. Cleveland, Fazly I. Ataullakhanov, and Ekaterina L. Grishchuk (2018). Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers. Biophysical Journal 114, 2640–2652, June 5, 2018 PMID: 29874614, PMCID: PMC6129181, DOI: 10.1016/j.bpj.2018.04.017

Moira A. McMahon, Thazha P. Prakash, Don W. Cleveland, C. Frank Bennett, and Meghdad Rahdar (2018). Chemically Modified Cpf1-CRISPR RNAs Mediate Efficient Genome Editing in Mammalian Cells. Molecular Therapy Vol. 26 No 5 May 2018 PMID: 29650467, PMCID: PMC5993945, DOI: 10.1016/j.ymthe.2018.02.031

Shahram Saberi, Jennifer E. Stauffer, Jie Jiang, Sandra Diaz Garcia, Amy E. Taylor, Derek Schulte, Takuya Ohkubo, Cheyenne L. Schloffman, Marcus Maldonado, Michael Baughn, Maria J. Rodriguez, Don Pizzo, Don Cleveland, John Ravits (2018). Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathologica (2018) 135:459–474 PMID: 29196813, PMCID: PMC5935138, DOI: 10.1007/s00401-017-1793-8

2017

Qiaozhen Ye, Dong Hyun Kim, Ihsan Dereli, Scott C Rosenberg, Goetz Hagemann, Franz Herzog, Attila Tóth, Don W Cleveland & Kevin D Corbett (2017). The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding. The EMBO Journal (2017) Vol 36, No 16 PMID: 28659378, PMCID: PMC5556265, DOI: 10.15252/embj.201797291

Fen-Biao Gao, Joel D. Richter, and Don W. Cleveland (2017). Rethinking Unconventional Translation in Neurodegeneration. Cell 171, 994-1000 PMID: 29149615, PMCID: PMC5728172, DOI: 10.1016/j.cell.2017.10.042

Peter Ly and Don W.Cleveland (2017). Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis. Trends in Cell Biology, 27: 917-930 PMID: 28899600, PMCID: PMC5696049, DOI: 10.1016/j.tcb.2017.08.005

Sandrine Da Cruz, Anh Bui, Shahram Saberi, Sandra K. Lee, Jennifer Stauffer, Melissa McAlonis-Downes, Derek Schulte, Donald P. Pizzo, Philippe A. Parone, Don W. Cleveland, John Ravits (2017). Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol (2017) 134:97–111 PMID: 28247063, PMCID: PMC5472502, DOI: 10.1007/s00401-017-1688-8

Peter Ly, Levi S. Teitz, Dong H. Kim, Ofer Shoshani, Helen Skaletsky, Daniele Fachinetti, David C. Page and Don W. Cleveland (2017). Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. NATURE CELL BIOLOGY VOLUME 19 | NUMBER 1 | JANUARY 2017 PMID: 27918550, PMCID: PMC5539760, DOI: 10.1038/ncb3450

Peter Ly and Don W. Cleveland (2017). Interrogating cell division errors using random and chromosome-specific missegregation approaches. CELL CYCLE 2017, VOL. 16, NO. 13, 1252–1258 PMID: 28650219, PMCID: PMC5531625, DOI: 10.1080/15384101.2017.1325047

Dara Ditsworth, Marcus Maldonado, Melissa McAlonis-Downes, Shuying Sun, Amanda Seelman, Kevin Drenner, Eveline Arnold, Shuo-Chien Ling, Donald Pizzo, John Ravits, Don W. Cleveland*, and Sandrine Da Cruz1* (2017). Mutant TDP-43 within motor neurons drives disease onset but not progression in Amyotrophic Lateral Sclerosis. Acta Neuropathol, March 2017 PMID: 28357566, PMCID: PMC5427168, DOI: 10.1007/s00401-017-1698-6

Fatima Gasset-Rosa, Carlos Chillon-Marinas, Alexander Goginashvili, Ranjit Singh Atwal, Jonathan W. Artates, Ricardos Tabet, Vanessa C. Wheeler, Anne G. Bang, Don W. Cleveland* and Clotilde Lagier-Tourenne* (2017). Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport. Neuron 94, 48–57, April 5, 2017 PMID: 28384474, PMCID: PMC5479704, DOI: 10.1016/j.neuron.2017.03.027

Lucie Y. Guo, Praveen Kumar Allu, Levani Zandarashvili, Kara L. McKinley, Nikolina Sekulic, Jennine M. Dawicki-McKenna, Daniele Fachinetti, Glennis A. Logsdon, Ryan M. Jamiolkowski, Don W. Cleveland, Iain M. Cheeseman & Ben E. Black (2017). Centromeres are maintained by fastening CENP-A to DNA and directing an arginine anchordependent nucleosome transition. NATURE COMMUNICATIONS | 8:15775 PMID: 28598437, PMCID: PMC5472775, DOI: 10.1038/ncomms15775

Michelle S. Levine, Bjorn Bakker, Bram Boeckx, Julia Moyett, James Lu, Benjamin Vitre, Diana C. Spierings, Peter M. Lansdorp, Don W. Cleveland, Diether Lambrechts, Floris Foijer, and Andrew J. Holland* (2017). Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Developmental Cell 40, 313–322, February 6, 2017 PMID: 28132847, PMCID: PMC5296221, DOI: 10.1016/j.devcel.2016.12.022

Moira A. McMahon and Don W. Cleveland (2017). Gene-editing therapy for neurological disease. Nature rev Neurol 13, 7-9 PMID: 34813019, DOI: 10.1007/s12035-021-02638-w

Yael Nechemia-Arbely, Daniele Fachinetti, Karen H. Miga, Nikolina Sekulic, Gautam V. Soni, Dong Hyun Kim, Adeline K. Wong, Ah Young Lee, Kristen Nguyen, Cees Dekker, Bing Ren, Ben E. Black, and Don W. Cleveland (2017) Human centromeric CENP-A chromatin is a homotypic, octameric nucleosome at all cell cycle points. J. Cell Biol. Vol. 216 No. 3 607–621 PMID: 28235947, PMCID: PMC5350519, DOI: 10.1083/jcb.201608083

Magdalini Polymenidou and Don W. Cleveland (2017). Biological Spectrum of Amyotrophic Lateral Sclerosis Prions. Cold Spring Harb Perspect Med PMID: 28062558, PMCID: PMC5666626, DOI: 10.1101/cshperspect.a024133

2016

Sandrine Da Cruz and Don W. Cleveland (2016). Disrupted nuclear importexport in neurodegeneration: Toxicity arises from amyloid-like protein accumulation in the cytoplasm, not the nucleus. Science 351, 125-126 doi: 10.1126/science.aad9872

Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis-Downes, Amanda Seelman, Jennifer E. Stauffer, Paymaan Jafar-nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo Chien Ling, Brian Myers, Jeffery Engelhardt, Melanie Katz, Michael Baughn, Oleksandr Platoshyn, Martin Marsala, Andy Watt, Charles J. Heyser, M. Colin Ard, Louis De Muynck, Lillian M. Daughrity, Deborah A. Swing, Lino Tessarollo, Chris J. Jung, Arnaud Delpoux, Daniel T. Utzschneider, Stephen M. Hedrick, Pieter J. de Jong, Dieter Edbauer, Philip Van Damme, Leonard Petrucelli, Christopher E. Shaw, C. Frank Bennett, Sandrine Da Cruz, John Ravits, Frank Rigo., Don W. Cleveland and Clotilde Lagier-Tourenne (2016). Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides TargetingGGGGCC-ContainingRNAs. Neuron 90, 1-6 PMID: 27112497, PMCID: PMC4860075, DOI: 10.1016/j.neuron.2016.04.006

Annelies Quaegebeur, Inmaculada Segura, Roberta Schmieder, Dries Verdegem, Ilaria Decimo, Francesco Bifari, Tom Dresselaers, Guy Eelen, Debapriva Ghosh, Shawn M. Davidson, Sandra Schoors, Dorien Broekaert, Bert Cruys, Kristof Govaerts, Carla De Legher, Ann Bouche´, Luc Schoonjans, Matt S. Ramer, Gene Hung, Goele Bossaert, Don W. Cleveland, Uwe Himmelreich, Thomas Voets, Robin Lemmens, C. Frank Bennett, Wim Robberecht, Katrien De Bock, Mieke Dewerchin, Bart Ghesquie`re, Sarah-Maria Fendt, and Peter Carmeliet (2016). Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. Cell Metabolism 23, 280-291 PMID: 26774962, PMCID: PMC4880550, DOI: 10.1016/j.cmet.2015.12.007

Yong-Jie Zhang, Tania F Gendron, Jonathan C Grima, Hiroki Sasaguri, Karen Jansen-West, Ya-Fei Xu, Rebecca B Katzman, Jennifer Gass, Melissa E Murray, Mitsuru Shinohara, Wen-Lang Lin, Aliesha Garrett, Jeannette N Stankowski, Lillian Daughrity, Jimei Tong, Emilie A Perkerson, Mei Yue, Jeannie Chew, Monica Castanedes Casey, Aishe Kurti, Zizhao S Wang, Amanda M Liesinger, Jeremy D Baker, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W Cleveland, Rosa Rademakers, Kevin B Boylan, Guojun Bu, Christopher D Link, Chad A Dickey, Jeffrey D Rothstein, Dennis W Dickson, John D Fryer & Leonard Petrucelli (2016). C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience doi:10.1038/nn.4272 PMID: 26998601, PMCID: PMC5138863, DOI: 10.1038/nn.4272

Sebastian Hoffmann, Marie Dumont, Viviana Barra, Peter Ly, Yael Nechemia-Arbely, Moira A. McMahon, Solene Herve, Don W. Cleveland, and Daniele Fachinetti (2016). CENP-A Is Dispensable for Mitotic Centromere Function after Initial Centromere/Kinetochore Assembly. Cell Reports 17, 2394–2404 PMID: 27880912, PMCID: PMC5134894, DOI: 10.1016/j.celrep.2016.10.084

Moira A. McMahon and Don W. Cleveland (2016). Gene-editing therapy for neurological disease. Nature Reviews Neurology 13:7–9 (2017) PMID: 27982043, DOI: 10.1038/nrneurol.2016.190

Tamara Seredenina, Zeynab Nayernia, Silvia Sorce, Ghassan J. Maghzal, Aleksandra Filippova, Shuo-Chien Ling, Olivier Basset, Olivier Plastre, Youssef Daali, Elisabeth J. Rushing, Maria T. Giordana, Don W. Cleveland, Adriano Aguzzi, Roland Stocker, Karl-Heinz Krause, Vincent Jaquet (2016). Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis. Free Radical Biology and Medicine 97 (2016) 95–108 PMID: 27212019, DOI: 10.1016/j.freeradbiomed.2016.05.016

J. Paul Taylor, Robert H. Brown Jr & Don W. Cleveland (2016). Decoding ALS: from genes to mechanism. Nature 539, 197-206 PMID: 27830784, PMCID: PMC5585017, DOI: 10.1038/nature20413

2015

Benjamin Vitre, Andrew J. Holland, Anita Kulukian, Ofer Shoshani, Maretoshi Hirai, Yin Wang, Marcus Maldonado, Thomas Cho, Jihane Boubaker, Deborah A. Swing, Lino Tessarollo, Sylvia M. Evans, Elaine Fuchs, and Don W. Cleveland (2015). Chronic centrosome amplification without tumorigenesis. PNAS E6321-E6330 PMID: 26578792, PMCID: PMC4655534, DOI: 10.1073/pnas.1519388112

Marka van Blitterswijk, Tania F. Gendron, Matthew C. Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Patricia H. Brown, Lillian M. Daughrity, Melissa E. Murray, Michael G. Heckman, Jie Jiang, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W. Cleveland, Keith A. Josephs, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Leonard Petrucelli, Bradley F. Boeve, Neill R. Graff-Radford, Kevin B. Boylan, Dennis W. Dickson, Rosa Rademakers (2015). Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathol (2015) 130:863–876 PMID: 26437865, PMCID: PMC4655160, DOI: 10.1007/s00401-015-1480-6

Shuying Sun, Ying Sun, Shuo-Chien Ling, Laura Ferraiuolo, Melissa McAlonis-Downes, Yiyang Zou, Kevin Drenner, Yin Wang, Dara Ditsworth, Seiya Tokunaga, Alex Kopelevich, Brian K. Kaspar, Clotilde Lagier-Tourenne, and Don W. Cleveland(2015). Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. PNAS 112, E6993-E7002 PMID: 26621731, PMCID: PMC4687558, DOI: 10.1073/pnas.1520639112

Meghdad Rahdar, Moira A. McMahon, Thazha P. Prakash, Eric E. Swayze, C. Frank Bennett, and Don W. Cleveland (2015). Synthetic CRISPR RNA-Cas9–guided genome editing in human cells. PNAS 112, E7110-E7117 PMID: 26589814, PMCID: PMC4697396, DOI: 10.1073/pnas.1520883112

Jacqueline C Mitchell, Remy Constable, Eva So, Caroline Vance, Emma Scotter, Leanne Glover, Tibor Hortobagyi, Eveline S. Arnold, Shuo-Chien Ling, Melissa McAlonis, Sandrine Da Cruz, Magda Polymenidou, Lino Tessarolo,Don W Cleveland and Christopher E Shaw (2015). Wild type human TDP-43 potentiates ALSlinked mutant TDP-43 driven progressive motor and cortical neuron degeneration with pathological features of ALS. Acta Neuropathologica Communications 3, 36-5 PMID: 26108367, PMCID: PMC4479086, DOI: 10.1186/s40478-015-0212-4

Anita Kulukiana, Andrew J. Hollandb, Benjamin Vitrec, Shruti Naika, Don W. Cleveland, and Elaine Fuchsa (2015). Epidermal development, growth control, and homeostasis in the face of centrosome amplification. PNAS E6311-E6320 PMID: 26578791, PMCID: PMC4655514, DOI: 10.1073/pnas.1518376112

Andrew J. Hollanda, Rita M. Reisb, Sherry Niessend, Cláudia Pereirab, Douglas A. Andrese, H. Peter Spielmanne, Don W. Cleveland, Arshad Desaia, and Reto Gassmannb (2015). Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell 26, 1845-1856 PMID: 25808490, PMCID: PMC4436830, DOI: 10.1091/mbc.E14-11-1560

Tania F. Gendron, Marka van Blitterswijk, Kevin F. Bieniek, Lillian M. Daughrity, Jie Jiang, Beth K. Rush, Otto Pedraza, John A. Lucas, Melissa E. Murray, Pamela Desaro, Amelia Robertson, Karen Overstreet, Colleen S. Thomas, Julia E. Crook, Monica Castanedes-Casey, Linda Rousseau, Keith A. Josephs, Joseph E. Parisi, David S. Knopman, Ronald C. Petersen, Bradley F. Boeve, Neill R. Graff-Radford, Rosa Rademakers, Clotilde Lagier-Tourenne, Dieter Edbauer, Don W. Cleveland, Dennis W. Dickson, Leonard Petrucelli, Kevin B. Boylan (2015). Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathol (2015) 130:559–573 PMID: 26350237, PMCID: PMC4575385, DOI: 10.1007/s00401-015-1474-4

Stefano Bertuzzi and Don W. Cleveland (2015). The curious incident of the translational dog that didn't bark. Trends in Cell Biology April 2015, Vol. 25, No. 4 PMID: 25817192, PMCID: PMC4508195, DOI: 10.1016/j.tcb.2015.02.003

Caroline Topham, Anthony Tighe, Peter Ly, Ailsa Bennett, Olivia Sloss, Louisa Nelson, Rachel A. Ridgway, David Huels, Samantha Littler, Claudia Schandl, Ying Sun, Beatrice Bechi, David J. Procter, Owen J. Sansom, Don W. Cleveland, and Stephen S. Taylor (2015). MYC Is a Major Determinant of Mitotic Cell Fate. Cancer Cell 28, 129–140 PMID: 26175417, PMCID: PMC4518499, DOI: 10.1016/j.ccell.2015.06.001

Daniele Fachinetti, Joo Seok Han, Moira A. McMahon, Peter Ly, Amira Abdullah, Alex J. Wong, andDon W. Cleveland(2015). DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function. Developmental Cell 33, 314–327 PMID: 25942623, PMCID: PMC4421092, DOI: 10.1016/j.devcel.2015.03.020

Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marian Hruska-Plochan, Melissa McAlonis-Downes, Salah Abu-Hamad, Guy Zoltsman, Tom Shani, Marcus Maldonado, Anh Bui, Michael Navarro, Huilin Zhou, Martin Marsala, Brian K. Kaspar, Sandrine Da Cruz, and Don W. Cleveland (2015). Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1. Neuron 86, 218–232 PMID: 25801706, PMCID: PMC4393372, DOI: 10.1016/j.neuron.2015.02.034

Shuying Sun, Shuo-Chien Ling, Jinsong Qiu, Claudio P. Albuquerque, Yu Zhou, Seiya Tokunaga, Hairi Li, Haiyan Qiu, Anh Bui, Gene W. Yeo, Eric J. Huang, Kevin Eggan, Huilin Zhou, Xiang-Dong Fu, Clotilde Lagier-Tourenne & Don W. Cleveland(2015). ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. NATURE COMMUNICATIONS | 6:6171 | DOI: 10.1038/ncomms7171 PMID: 25625564, PMCID: PMC4338613, DOI: 10.1038/ncomms7171

2014

Andrew J. Holland, and Don W. Cleveland (2014). Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy? Cancer Cell 26, 151-153 PMID: 25117704, PMCID: PMC4148003, DOI: 10.1016/j.ccr.2014.07.017

Dani L Bodor, João F Mata, Mikhail Sergeev, Ana Filipa David, Kevan J Salimian, Tanya Panchenko, Don W Cleveland, Ben E Black, Jagesh V Shah, Lars ET Jansen (2014). The quantitative architecture of centromeric chromatin. eLife 2014;3:e02137 PMID: 25027692, PMCID: PMC4091408, DOI: 10.7554/eLife.02137

Han, J.S., Vitre, B., Fachinetti, D., and Cleveland, D. W. (2014). Bimodal activation of BubR1 by Bub3 sustains mitotic checkpoint signaling. Proc. Natl. Acad. Sci. 111, E4185-4193 PMID: 25246557, PMCID: PMC4210015, DOI: 10.1073/pnas.1416277111

Cortes, C.J., Ling, S.-C., Guo, L, Hung, G., Tsunemi, T., Ly, L., Lopez, E., Sopher, B.L., Bennett, C.F., Shelton, D., Cleveland, D.W. and La Spada, D.W. (2014). Silencing muscle expression of mutant androgen receptor protein completely rescues systemic and motor neuron disease phenotypes in a Spinal & Bulbar Muscular Atrophy mouse model. Neuron 82, 295-307 PMID: 24742458, PMCID: PMC4096235, DOI: 10.1016/j.neuron.2014.03.001

Winkler, E.A., Sengill, J.D., Sagare, A.P., Zhao, Z., Ma, Q., Zuniga, E., Want, Y., Zhong, Z., Sullivan, J.S., Griffin, J.H.,Cleveland, D.W. and Zlokovic, B.V. (2014). Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proc. Natl. Acad. Sci. 111, E1035-E1042 PMID: 24591593, PMCID: PMC3964055, DOI: 10.1073/pnas.1401595111

Crotti, A., Benner, C., Kerman, B., Lagier-Tourenne, C., Kordasiewicz, H., Pollard, J.W., Zuccato, C., Cattaneo, E., Gage, F.H., Cleveland, D.W., and Glass, C.K. (2014). Mutant Huntingtin promotes cell-autonomous microglia activation and neuro-inflammation via myeloid lineage-determining factors PU.1-C/EBP. Nat. Neurosci., 17, 513-521 PMID: 24584051, PMCID: PMC4113004, DOI: 10.1038/nn.3668

Lobsiger, C.S. and Cleveland, D.W. (2014). Reply to Woodruff et al.: C1q and C3-dependent complement pathway activation does not contribute to disease in SOD1 mutant ALS mice. Proc. Natl. Acad. Sci. 111, E5 PMID: 24555201, PMCID: PMC3890793, DOI: 10.1073/pnas.1321606111

Meyer, K., Ferraiuolo, L., Miranda, C.J., Likhite, S., McElroy, S., Renusch, S., Ditsworth, D., Lagier-Tournenne, C., Smith, R.A., Ravits, J., Burghes, A., Shaw, P.J., Cleveland, D.W., Kolb, S.J. and Kaspar, B.K (2014). Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc. Natl. Acad. Sci. 111, 829-832 PMID: 24379375, PMCID: PMC3896192, DOI: 10.1073/pnas.1314085111

Vitre B., Gudimchuk N., Borda R., Kim Y., Heuser JE., Cleveland D.W., Grishchuk EL. (2014) Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E. Mol Biol Cell. 2014 Jun 11 PMID: 24920822, PMCID: PMC4116301, DOI: 10.1091/mbc.E14-01-0698

Mirzaa G.M., Vitre B., Carpenter G., Abramowicz I., Gleeson J.G., Paciorkowski A.R., Cleveland D.W., Dobyns W.B., O'Driscoll M. Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism. Hum Genet. 2014 Apr 20 PMID: 24748105, PMCID: PMC4415612, DOI: 10.1007/s00439-014-1443-3

2013

Silk, A.D., Zasadil, L.M., Holland, A.J., Vitre, B., Cleveland, D.W.*, and Weaver, B.A.* (2013). Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. Proc. Natl. Acad. Sci. 110, E4134-E4141 PMID: 24133140, PMCID: PMC3816416, DOI: 10.1073/pnas.1317042110

Lobsiger, C., Boillee, S., Sun, S., Khan, A.M., McAlonis-Downes, M., Lewcock, J. and Cleveland, D.W (2013). C1q induction and activation of the classic complement pathway do not contribute to ALS toxicity in mutant SOD1 mice. Proc. Natl. Acad. Sci. 110, E4385-E4392 PMID: 24170856, PMCID: PMC3831990, DOI: 10.1073/pnas.1318309110

Lagier-Tourenne, C., Baughn, M., Rigo, F., Sun, Shuying, Liu,P., Li, H.-R., Jiang, Jie, Watt, A., Chun, Seung, Katz, Melanie, Qiu, J., Ling, S.-C., Zhu, Q., Polymenidou, M., Drenner, K., Artates, J.W., McAlonis, M.M., Hung, G., Markmiller, S., Hutt, K.R., Pizzo, D., Baloh, R.H., Vandenberg, S., Yeo, G.W., Fu, X-D., Bennett, C.F., Cleveland, D.W.* and Ravits, J.* (2013). Targeted degradation of sense and antisense C9orf72 nuclear RNA foci as therapy for amyotrophic lateral sclerosis and frontotemporal dementia. Proc. Natl. Acad. Sci 110, E4530-E4539 PMID: 24170860, PMCID: PMC3839752, DOI: 10.1073/pnas.1318835110

Foust, K.D., Salazar, D.L., Likhite, S., Ferraiuolo, L., Ditsworth, D., Ilieva, H., Meyer, K., Schmelzer, L., Braun, L., Cleveland, D.W.* and Kaspar, B.K.* (2013). Therapeutic delivery of AAV9-mediated SOD1 suppression slows disease progression and extends survival in two mouse models of ALS. Molec. Therapy 21, 2148-2159 PMID: 24008656, PMCID: PMC3863799, DOI: 10.1038/mt.2013.211

Parone, P.A., Da Cruz, S., Han, J.S., McAlonis-Downes, M., Vetto, A.P., Lee, S.K., Tseng, E., and Cleveland, D.W. (2013). Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J. Neurosci. 33, 4657-4671 PMID: 23486940, PMCID: PMC3711648, DOI: 10.1523/JNEUROSCI.1119-12.2013

Ling, S.C., Polymenidou, M., and Cleveland, D.W. (2013). Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis. Neuron 79, 416-438 PMID: 23931993, PMCID: PMC4411085, DOI: 10.1016/j.neuron.2013.07.033

Kang, S.H., Li, Y., Fukaya, M., Lorenzini, I., Cleveland, D.W., Ostrow, L.W., Rothstein, J.D., and Bergles, D.E. (2013). Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat. Neurosci. 16, 571-579 PMID: 23542689, PMCID: PMC3637847, DOI: 10.1038/nn.3357

Earnshaw, W.C. and Cleveland, D.W. (2013). CENP-A and the CENP nomenclature: response to Talbert and Henikoff. Trends Genet. 29, 500-502 PMID: 23910159, DOI: 10.1016/j.tig.2013.06.008

Earnshaw, W.C., Allshire, R.C., Black, B.E., Bloom, K., Brinkley, B.R., Brown, W., Cheeseman, I.M., Choo, K.H., Copenhaver, G.P., Deluca, J.G., Desai, A., Diekmann, S., Erhardt, S., Fitzgerald-Hayes, M., Foltz, D., Fukagawa, T., Gassmann, R., Gerlich, D.W., Glover, D.M., Gorbsky, G.J., Harrison, S.C., Heun, P., Hirota, T., Jansen, L.E., Karpen, G., Kops, G.J., Lampson, M.A., Lens, S.M., Losada, A., Luger, K., Maiato, H., Maddox, P.S., Margolis, R.L., Masumoto, H., McAinsh, A.D., Mellone, B.G., Meraldi, P., Musacchio, A., Oegema, K., O'Neill, R.J., Salmon, E.D., Scott, K.C., Straight, A.F., Stukenberg, P.T., Sullivan, B.A., Sullivan, K.F., Sunkel, C.E., Swedlow, J.R., Walczak, C.E., Warburton, P.E., Westermann, S., Willard, H.F., Wordeman, L., Yanagida, M., Yen, T.J., Yoda, K., and Cleveland, D.W. (2013). Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome. Res. 21, 101-106 PMID: 23580138, PMCID: PMC3627038, DOI: 10.1007/s10577-013-9347-y

Han, J.S., Holland, A.J., Fachinetti, D., Kulukian, A., Cetin, B., and Cleveland, D.W. (2013). Catalytic assembly of the mitotic checkpoint inhibitor BubR1-Cdc20 by a Mad2-induced functional switch in Cdc20. Mol. Cell 51, 92-104 PMID: 23791783, PMCID: PMC3713096, DOI: 10.1016/j.molcel.2013.05.019

Gudimchuk, N., Vitre, B., Kim, Y., Kiyatkin, A., Cleveland, D.W., Ataullakhanov,F.I., and Grishchuk,E.L. (2013). Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nat. Cell Biol. 15, 1079-1088 PMID: 23955301, PMCID: PMC3919686, DOI: 10.1038/ncb2831

Fachinetti, D., Folco, H.D., Nechemia-Arbely, Y., Valente, L.P., Nguyen, K., Wong, A.J., Zhu, Q., Holland, A.J., Desai, A., Jansen, L.E., and Cleveland, D.W. (2013). A two-step mechanism for epigenetic specification of centromere identity and function. Nat. Cell Biol. 15, 1056-1066 PMID: 23873148, PMCID: PMC4418506, DOI: 10.1038/ncb2805

Arnold, E.S., Ling, S.C., Huelga, S.C., Lagier-Tourenne, C., Polymenidou, M., Ditsworth, D., Kordasiewicz, H.B., McAlonis-Downes, M., Platoshyn, O., Parone, P.A., Da Cruz, S., Clutario, K.M., Swing, D., Tessarollo, L., Marsala, M., Shaw, C.E., Yeo, G.W., and Cleveland, D.W. (2013). ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc. Natl. Acad. Sci. 110, E736-E745 PMID: 23382207, PMCID: PMC3581922, DOI: 10.1073/pnas.1222809110

2012

Yu, D., Pendergraff, H., Liu, J., Kordasiewicz, H.B., Cleveland, D.W., Swayze, E.E., Lima, W.F., Crooke, S.T., Prakash, T.P., and Corey, D.R. (2012). Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell 150, 895-908 PMID: 22939619, PMCID: PMC3444165, DOI: 10.1016/j.cell.2012.08.002

Vitre, B.D. and Cleveland, D.W. (2012). Centrosomes, chromosome instability (CIN) and aneuploidy. Curr. Opin. Cell Biol. 24, 809-815 PMID: 23127609, PMCID: PMC3621708, DOI: 10.1016/j.ceb.2012.10.006

Sun, S. and Cleveland, D.W. (2012). TDP-43 toxicity and the usefulness of junk. Nat. Genet. 44, 1289-1291 PMID: 23192178, PMCID: PMC3612973, DOI: 10.1038/ng.2473

Polymenidou, M., Lagier-Tourenne, C., Hutt, K.R., Bennett, C.F., Cleveland, D.W., and Yeo, G.W (2012). Misregulated RNA processing in amyotrophic lateral sclerosis. Brain Res. 1462, 3-15 PMID: 22444279, PMCID: PMC3707312, DOI: 10.1016/j.brainres.2012.02.059

Polymenidou, M. and Cleveland, D.W. (2012). Prion-like spread of protein aggregates in neurodegeneration. J. Exp. Med. 209, 889-893 PMID: 22566400, PMCID: PMC3348110, DOI: 10.1084/jem.20120741

Nechemia-Arbely, Y., Fachinetti, D., and Cleveland, D.W. (2012). Replicating centromeric chromatin: spatial and temporal control of CENP-A assembly. Exp. Cell Res. 318, 1353-1360 PMID: 22561213, PMCID: PMC3616609, DOI: 10.1016/j.yexcr.2012.04.007

Lagier-Tourenne, C., Polymenidou, M., Hutt, K.R., Vu,A. Q., Baughn, M., Huelga, S.C., Clutario, K.M., Ling, S.C., Liang, T.Y., Mazur, C., Wancewicz, E., Kim, A.S., Watt, A., Freier, S., Hicks, G.G., Donohue, J.P., Shiue, L., Bennett, C.F., Ravits, J., Cleveland, D.W.*, and Yeo, G.W.* (2012). Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat. Neurosci. 15, 1488-1497 PMID: 23023293, PMCID: PMC3586380, DOI: 10.1038/nn.3230

Kolano, A., Brunet, S., Silk, A.D.,Cleveland, D.W.*, and Verlhac, M.H.* (2012). Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension. Proc. Natl. Acad. Sci. 109, E1858-E1867 PMID: 22552228, PMCID: PMC3390881, DOI: 10.1073/pnas.1204686109

Holland, A.J. and Cleveland, D.W. (2012). Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep. 13, 501-514 PMID: 22565320, PMCID: PMC3367240, DOI: 10.1038/embor.2012.55

Kordasiewicz, H.B., Stanek, L.M., Wancewicz, E.V., Mazur, C., McAlonis, M.M., Pytel, K.A., Artates, J.W., Weiss, A., Cheng, S.H., Shihabuddin, L.S., Hung, G., Bennett, C.F., and Cleveland, D.W (2012). Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis. Neuron 74, 1031-1044 PMID: 22726834, PMCID: PMC3383626, DOI: 10.1016/j.neuron.2012.05.009

Holland, A.J., Fachinetti, D., Da Cruz, S., Zhu, Q., Vitre, B., Lince-Faria, M., Chen, D., Parish, N., Verma, I.M., Bettencourt-Dias, M., andCleveland, D.W. (2012). Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol. Biol. Cell 23, 1838-1845 PMID: 22456511, PMCID: PMC3350549, DOI: 10.1091/mbc.E11-12-1043

Holland, A.J. and Cleveland, D.W. (2012). The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. J. Clin. Invest 122, 4325-4328 PMID: 23187131, PMCID: PMC3533566, DOI: 10.1172/JCI66420

Holland, A.J., Fachinetti, D., Zhu, Q., Bauer, M., Verma, I.M., Nigg, E.A., and Cleveland, D.W. (2012). The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev. 26, 2684-2689 PMID: 23249732, PMCID: PMC3533073, DOI: 10.1101/gad.207027.112

Holland, A.J., Fachinetti, D., Han,J .S., and Cleveland, D.W. (2012). Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc. Natl. Acad. Sci. 109, E3350-E3357 PMID: 23150568, PMCID: PMC3523849, DOI: 10.1073/pnas.1216880109

Holland, A.J. and Cleveland, D.W. (2012). Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat. Med. 18, 1630-1638 PMID: 23135524, PMCID: PMC3616639, DOI: 10.1038/nm.2988

Hefferan, M.P., Galik, J., Kakinohana, O., Sekerkova, G., Santucci, C., Marsala, S., Navarro, R., Hruska-Plochan, M., Johe, K., Feldman, E., Cleveland, D.W., and Marsala, M. (2012). Human neural stem cell replacement therapy for amyotrophic lateral sclerosis by spinal transplantation. PLoS. One. 7, e42614 PMID: 22916141, PMCID: PMC3423406, DOI: 10.1371/journal.pone.0042614

Da Cruz, S., Parone, P.A., Lopes, V.S., Lillo, C., McAlonis-Downes, M., Lee, S.K., Vetto, A.P., Petrosyan, S., Marsala, M., Murphy, A.N., Williams, D.S., Spiegelman, B.M., and Cleveland, D.W. (2012). Elevated PGC-1alpha activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab 15, 778-786 PMID: 22560226, PMCID: PMC3565468, DOI: 10.1016/j.cmet.2012.03.019

2011

Vande, V.C., McDonald, K.K., Boukhedimi, Y., McAlonis-Downes, M., Lobsiger, C.S., Bel, H.S., Zandona, A., Julien, J.P., Shah, S.B., and Cleveland, D.W. (2011). Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset. PLoS. One. 6, e22031 PMID: 21779368, PMCID: PMC3136936, DOI: 10.1371/journal.pone.0022031

Polymenidou, M., Lagier-Tourenne, C., Hutt, K.R., Huelga, S.C., Moran, J., Liang, T.Y., Ling, S.C., Sun, E., Wancewicz, E., Mazur, C., Kordasiewicz, H., Sedaghat, Y., Donohue, J.P., Shiue, L., Bennett, C.F., Yeo, G.W., and Cleveland, D.W.(2011). Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat. Neurosci. 14, 459-468 PMID: 21358643, PMCID: PMC3094729, DOI: 10.1038/nn.2779

Polymenidou, M. and Cleveland, D.W. (2011). The seeds of neurodegeneration: prion-like spreading in ALS. Cell 147, 498-508 PMID: 22036560, PMCID: PMC3220614, DOI: 10.1016/j.cell.2011.10.011

Kolodner, R.D., Cleveland, D.W., and Putnam, C.D. (2011). Cancer. Aneuploidy drives a mutator phenotype in cancer. Science 333, 942-943 PMID: 21852477, PMCID: PMC3806716, DOI: 10.1126/science.1211154

Da Cruz, S. and Cleveland, D.W. (2011). Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr. Opin. Neurobiol. 21, 904-919 PMID: 21813273, PMCID: PMC3228892, DOI: 10.1016/j.conb.2011.05.029

Black, B.E. and Cleveland, D.W. (2011). Epigenetic centromere propagation and the nature of CENP-a nucleosomes. Cell 144, 471-479 PMID: 21335232, PMCID: PMC3061232, DOI: 10.1016/j.cell.2011.02.002

2010

Radulescu, A.E. and Cleveland, D.W. (2010). NuMA after 30 years: the matrix revisited. Trends Cell Biol. 20, 214-222 PMID: 20137953, PMCID: PMC3137513, DOI: 10.1016/j.tcb.2010.01.003

Ling, S.C., Albuquerque, C.P., Han, J.S., Lagier-Tourenne, C., Tokunaga, S., Zhou, H., and Cleveland, D.W. (2010). ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc. Natl. Acad. Sci. 107, 13318-13323 PMID: 20624952, PMCID: PMC2922163, DOI: 10.1073/pnas.1008227107

Li, Q., Vande, V.C., Israelson, A., Xie, J., Bailey, A.O., Dong, M.Q., Chun, S.J., Roy, T., Winer, L., Yates, J.R., Capaldi, R.A., Cleveland, D.W., and Miller, T.M. (2010). ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc. Natl. Acad. Sci. 107, 21146-21151 PMID: 21078990, PMCID: PMC3000256, DOI: 10.1073/pnas.1014862107

Lan, W. and Cleveland, D.W. (2010). A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J. Cell Biol. 190, 21-24 PMID: 20624898, PMCID: PMC2911672, DOI: 10.1083/jcb.201006080

Lan, W. and Cleveland, D.W. (2010). Multiclassifier proteomics to define complexes yields new chromosomal proteins. Dev. Cell 19, 356-359 PMID: 20833356, PMCID: PMC2943763, DOI: 10.1016/j.devcel.2010.08.017

Lagier-Tourenne, C. and Cleveland, D.W. (2010). Neurodegeneration: An expansion in ALS genetics. Nature 466, 1052-1053 PMID: 20740002, DOI: 10.1038/4661052a

Lagier-Tourenne, C., Polymenidou, M., and Cleveland, D.W. (2010). TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum. Mol. Genet. 19, R46-R64 PMID: 20400460, PMCID: PMC3167692, DOI: 10.1093/hmg/ddq137

Kim, Y., Holland, A.J., Lan, W., and Cleveland, D.W. (2010). Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142, 444-455 PMID: 20691903, PMCID: PMC2921712, DOI: 10.1016/j.cell.2010.06.039

Israelson, A., Arbel, N., Da, C.S., Ilieva, H., Yamanaka, K., Shoshan-Barmatz, V., and Cleveland, D.W (2010). Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron 67, 575-587 PMID: 20797535, PMCID: PMC2941987, DOI: 10.1016/j.neuron.2010.07.019

Holland, A.J., Lan, W., Niessen, S., Hoover, H., and Cleveland, D.W. (2010). Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J. Cell Biol. 188, 191-198 PMID: 20100909, PMCID: PMC2813471, DOI: 10.1083/jcb.200911102

Hatch, E.M., Kulukian, A., Holland, A.J., Cleveland, D.W., and Stearns, T. (2010). Cep152 interacts with Plk4 and is required for centriole duplication. J. Cell Biol. 191, 721-729 PMID: 21059850, PMCID: PMC2983069, DOI: 10.1083/jcb.201006049

Holland, A.J., Lan, W., and Cleveland, D.W. (2010). Centriole duplication: A lesson in self-control. Cell Cycle 9, 2731-2736 PMID: 20647763, PMCID: PMC3040958, DOI: 10.4161/cc.9.14.12184

Gurden, M.D., Holland, A.J., van, Z.W., Tighe, A., Vergnolle, M.A., Andres, D.A., Spielmann, H.P., Malumbres, M., Wolthuis, R.M., Cleveland, D.W., and Taylor, S.S. (2010). Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. J. Cell Sci. 123, 321-330 PMID: 20053638, PMCID: PMC2816182, DOI: 10.1242/jcs.062075

Gassmann, R., Holland, A.J., Varma, D., Wan, X., Civril, F., Cleveland, D.W., Oegema, K., Salmon, E.D., and Desai, A. (2010). Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev. 24, 957-971 PMID: 20439434, PMCID: PMC2861194, DOI: 10.1101/gad.1886810

Cetin, B. and Cleveland, D.W. (2010). How to survive aneuploidy. Cell 143, 27-29 PMID: 20887888, PMCID: PMC2955074, DOI: 10.1016/j.cell.2010.09.030

Black, B.E., Jansen, L.E., Foltz, D.R., and Cleveland, D.W. (2010). Centromere identity, function, and epigenetic propagation across cell divisions. Cold Spring Harb. Symp. Quant. Biol. 75, 403-418 PMID: 21467140, PMCID: PMC3140419, DOI: 10.1101/sqb.2010.75.038

2009

Zhong, Z., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J.A., Lane, S., Zlokovic, A.B., Liu, T., Griffin, J.H., Chow, N., Castellino, F.J., Stojanovic, K., Cleveland, D.W., and Zlokovic, B.V. (2009). Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J. Clin. Invest 119, 3437-3449 PMID: 19841542, PMCID: PMC2769191, DOI: 10.1172/JCI38476

Zeitlin, S.G., Baker, N.M., Chapados, B.R., Soutoglou, E., Wang, J.Y., Berns, M.W., and Cleveland, D.W. (2009). Double-strand DNA breaks recruit the centromeric histone CENP-A. Proc. Natl. Acad. Sci. 106, 15762-15767 PMID: 19717431, PMCID: PMC2747192, DOI: 10.1073/pnas.0908233106

Weaver, B.A. and Cleveland, D.W. (2009). The role of aneuploidy in promoting and suppressing tumors. J. Cell Biol. 185, 935-937 PMID: 19528293, PMCID: PMC2711620, DOI: 10.1083/jcb.200905098

Silk, A.D., Holland, A.J., andCleveland, D.W. (2009). Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J. Cell Biol. 184, 677-690 PMID: 19255246, PMCID: PMC2686415, DOI: 10.1083/jcb.200810091

Samoshkin, A., Arnaoutov, A., Jansen, L.E., Ouspenski, I., Dye, L., Karpova, T., McNally, J., Dasso, M., Cleveland, D.W., and Strunnikov,A. (2009). Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS. One. 4, e6831 PMID: 19714251, PMCID: PMC2730017, DOI: 10.1371/journal.pone.0006831

Lobsiger, C.S., Boillee, S., McAlonis-Downes, M., Khan, A.M., Feltri, M.L., Yamanaka, K., and Cleveland, D.W.(2009). Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc. Natl. Acad. Sci. 106, 4465-4470 PMID: 19251638, PMCID: PMC2657393, DOI: 10.1073/pnas.0813339106

Lagier-Tourenne, C. and Cleveland, D.W. (2009). Rethinking ALS: the FUS about TDP-43. Cell 136, 1001-1004 PMID: 19303844, PMCID: PMC3110083, DOI: 10.1016/j.cell.2009.03.006

Kulukian, A., Han, J.S., and Cleveland, D.W. (2009). Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding. Dev. Cell 16, 105-117 PMID: 19154722, PMCID: PMC2655205, DOI: 10.1016/j.devcel.2008.11.005

Ilieva, H., Polymenidou, M., and Cleveland, D.W. (2009). Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol. 187, 761-772 PMID: 19951898, PMCID: PMC2806318, DOI: 10.1083/jcb.200908164

Holland, A.J. and Cleveland, D.W. (2009). Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis. Nat. Rev. Mol. Cell Biol. 10, 478-487 PMID: 19546858, PMCID: PMC3154738, DOI: 10.1038/nrm2718

Garcia, M.L., Rao, M.V., Fujimoto, J., Garcia, V.B., Shah, S.B., Crum, J., Gotow, T., Uchiyama, Y., Ellisman, M., Calcutt, N.A., and Cleveland, D.W. (2009). Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J. Neurosci. 29, 1277-1284 PMID: 19193875, PMCID: PMC2782950, DOI: 10.1523/JNEUROSCI.3765-08.2009

Foltz, D.R., Jansen, L.E., Bailey, A.O., Yates, J.R., III, Bassett, E.A., Wood, S., Black, B.E., and Cleveland, D.W. (2009). Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. Cell 137, 472-484 PMID: 19410544, PMCID: PMC2747366, DOI: 10.1016/j.cell.2009.02.039

Cleveland, D.W. , Yamanaka, K., and Bomont, P. (2009). Gigaxonin controls vimentin organization through a tubulin chaperone-independent pathway. Hum. Mol. Genet. 18, 1384-1394 PMID: 19168853, PMCID: PMC2664145, DOI: 10.1093/hmg/ddp044

2008

Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M.K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D.W., and Zlokovic, B.V. (2008). ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci. 11, 420-422 PMID: 18344992, PMCID: PMC2895310, DOI: 10.1038/nn2073

Yamanaka, K., Chun, S.J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D.H., Takahashi, R., Misawa, H., andCleveland, D.W. (2008). Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. 11, 251-253 PMID: 18246065, PMCID: PMC3137510, DOI: 10.1038/nn2047

Yamanaka, K., Boillee, S., Roberts, E.A., Garcia, M.L., McAlonis-Downes, M., Mikse, O.R., Cleveland, D.W., and Goldstein,L.S. (2008). Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice. Proc. Natl. Acad. Sci. 105, 7594-7599 PMID: 18492803, PMCID: PMC2396671, DOI: 10.1073/pnas.0802556105

Weaver, B.A. and Cleveland, D.W. (2008). The aneuploidy paradox in cell growth and tumorigenesis. Cancer Cell 14, 431-433 PMID: 19061834, PMCID: PMC3132552, DOI: 10.1016/j.ccr.2008.11.011

Weaver, B.A., Silk, A.D., and Cleveland, D.W. (2008). Low rates of aneuploidy promote tumorigenesis while high rates of aneuploidy cause cell death and tumor suppression. Cell Oncol. 30, 453 PMID: 18791276, PMCID: PMC4618964, DOI: 10.3233/clo-2008-0445

Vande, V.C., Miller, T.M., Cashman, N.R., and Cleveland, D.W. (2008). Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc. Natl. Acad. Sci. 105, 4022-4027 PMID: 18296640, PMCID: PMC2268797, DOI: 10.1073/pnas.0712209105

Polymenidou, M. and Cleveland, D.W. (2008). Motor neuron disease: The curious ways of ALS. Nature 454, 284-285 PMID: 18633404, PMCID: PMC3625042, DOI: 10.1038/454284a

Kim, Y., Heuser, J.E., Waterman, C.M., and Cleveland, D.W. (2008). CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J. Cell Biol. 181, 411-419 PMID: 18443223, PMCID: PMC2364708, DOI: 10.1083/jcb.200802189

Jelluma, N., Brenkman, A.B., McLeod, I., Yates, J.R., III, Cleveland, D.W., Medema, R.H., and Kops, G.J. (2008). Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes. PLoS. One. 3, e2415 PMID: 18545697, PMCID: PMC2408436, DOI: 10.1371/journal.pone.0002415

Ilieva, H.S., Yamanaka, K., Malkmus, S., Kakinohana, O., Yaksh, T., Marsala, M., and Cleveland, D.W (2008). Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death. Proc. Natl. Acad. Sci. 105, 12599-12604 PMID: 18719118, PMCID: PMC2527957, DOI: 10.1073/pnas.0805422105

Holland, A.J. and Cleveland, D.W. (2008). Beyond genetics: surprising determinants of cell fate in antitumor drugs. Cancer Cell 14, 103-105 PMID: 18691543 PMCID: PMC3132553, DOI: 10.1016/j.ccr.2008.07.010

Detmer, S.A., Vande, V.C., Cleveland, D.W., and Chan, D.C. (2008). Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum. Mol. Genet. 17, 367-375 PMID: 17959936, DOI: 10.1093/hmg/ddm314

Dequen, F., Bomont, P., Gowing, G., Cleveland, D.W., and Julien, J.P. (2008). Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1. J. Neurochem. 107, 253-264 PMID: 18680552, PMCID: PMC3657508, DOI: 10.1111/j.1471-4159.2008.05601.x

Chang, Y., Kong, Q., Shan, X., Tian, G., Ilieva, H., Cleveland, D.W., Rothstein, J.D., Borchelt, D.R., Wong, P.C., and Lin, C.L. (2008). Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS. One. 3, e2849 PMID: 18682740, PMCID: PMC2481395, DOI: 10.1371/journal.pone.0002849

Boillee, S. and Cleveland, D.W. (2008). Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. J. Clin. Invest 118, 474-478 PMID: 18219386, PMCID: PMC2213376, DOI: 10.1172/JCI34613

2007

Weaver, B.A., Silk, A.D., Montagna, C., Verdier-Pinard, P., and Cleveland, D.W. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11, 25-36 PMID: 17189716, DOI: 10.1016/j.ccr.2006.12.003

Weaver, B.A. and Cleveland, D.W. (2007). Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint". Science 316, 982 PMID: 17510348, DOI: 10.1126/science.1139523

Weaver, B.A. and Cleveland, D.W. (2007). Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 67, 10103-10105 PMID: 17974949, PMCID: PMC3132555, DOI: 10.1158/0008-5472.CAN-07-2266

Rakhit, R., Robertson, J., Vande, V.C., Horne, P., Ruth, D.M., Griffin, J., Cleveland, D.W., Cashman, N.R., and Chakrabartty, A. (2007). An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS. Nat. Med. 13, 754-759 PMID: 17486090, DOI: 10.1038/nm1559

Lobsiger, C.S., Boillee, S., and Cleveland, D.W. (2007). Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc. Natl. Acad. Sci. 104, 7319-7326 PMID: 17463094, PMCID: PMC1863491, DOI: 10.1073/pnas.0702230104

Lobsiger, C.S. and Cleveland, D.W. (2007). Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease. Nat. Neurosci. 10, 1355-1360 PMID: 17965655, PMCID: PMC3110080, DOI: 10.1038/nn1988

Jansen, L.E., Black, B.E., Foltz, D.R., and Cleveland, D.W. (2007). Propagation of centromeric chromatin requires exit from mitosis. J. Cell Biol. 176, 795-805 PMID: 17339380, PMCID: PMC2064054, DOI: 10.1083/jcb.200701066

Gruzman, A., Wood, W.L., Alpert, E., Prasad, M.D., Miller, R.G., Rothstein, J.D., Bowser, R., Hamilton, R., Wood, T.D., Cleveland, D.W., Lingappa, V.R., and Liu, J. (2007). Common molecular signature in SOD1 for both sporadic and familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. 104, 12524-12529 PMID: 17636119, PMCID: PMC1941502, DOI: 10.1073/pnas.0705044104

Conde e Silva, Black, B.E., Sivolob, A., Filipski, J., Cleveland, D.W., and Prunell, A. (2007). CENP-A-containing nucleosomes: easier disassembly versus exclusive centromeric localization. J. Mol. Biol. 370, 555-573 PMID: 17524417, DOI: 10.1016/j.jmb.2007.04.064

Black, B.E., Jansen, L.E., Maddox, P.S., Foltz, D.R., Desai, A.B., Shah, J.V., and Cleveland, D.W. (2007). Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol. Cell 25, 309-322 PMID: 17244537, DOI: 10.1016/j.molcel.2006.12.018

Black, B.E., Brock, M.A., Bedard, S., Woods, V.L., Jr., and Cleveland, D.W. (2007). An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc. Natl. Acad. Sci. 104, 5008-5013 PMID: 17360341, PMCID: PMC1829255, DOI: 10.1073/pnas.0700390104

Bailey, A.O., Miller, T.M., Dong, M.Q., Vande, V.C., Cleveland, D.W., and Yates, J.R. (2007). RCADiA: simple automation platform for comparative multidimensional protein identification technology. Anal. Chem. 79, 6410-6418 PMID: 17616168, PMCID: PMC2528021, DOI: 10.1021/ac070585g

2006

Yamanaka, K., Miller, T.M., McAlonis-Downes, M., Chun, S.J., and Cleveland, D.W. (2006). Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Ann. Neurol. 60, 95-104 PMID: 16802286, DOI: 10.1002/ana.20888

Weaver, B.A., Silk, A.D., and Cleveland, D.W. (2006). Cell biology: nondisjunction, aneuploidy and tetraploidy. Nature 442, E9-10 PMID: 16915240, DOI: 10.1038/nature05139

Weaver, B.A. and Cleveland, D.W. (2006). Does aneuploidy cause cancer? Curr. Opin. Cell Biol. 18, 658-667 PMID: 17046232, DOI: 10.1016/j.ceb.2006.10.002

Wang, Z., Shah, J.V., Berns, M.W., and Cleveland, D.W. (2006). In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys. J. 91, 343-351 PMID: 16603490, PMCID: PMC1479085, DOI: 10.1529/biophysj.105.077891

Smith, R.A., Miller, T.M., Yamanaka, K., Monia, B.P., Condon, T.P., Hung, G., Lobsiger, C.S., Ward, C.W., McAlonis-Downes, M., Wei, H., Wancewicz, E.V., Bennett, C.F., and Cleveland, D.W. (2006). Antisense oligonucleotide therapy for neurodegenerative disease. J. Clin. Invest 116, 2290-2296 PMID: 16878173, PMCID: PMC1518790, DOI: 10.1172/JCI25424

Miller, T.M., Kim, S.H., Yamanaka, K., Hester, M., Umapathi, P., Arnson, H., Rizo, L., Mendell, J.R., Gage, F.H., Cleveland, D.W., and Kaspar, B.K. (2006). Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. 103, 19546-19551 PMID: 17164329, PMCID: PMC1748262, DOI: 10.1073/pnas.0609411103

Ross, C.A. and Cleveland, D.W. (2006). Intercellular miscommunication in polyglutamine pathogenesis. Nat. Neurosci. 9, 1205-1206 PMID: 17001335, DOI: 10.1038/nn1006-1205

Miller, T.M., Smith, R.A., and Cleveland, D.W. (2006). Amyotrophic lateral sclerosis and gene therapy. Nat. Clin. Pract. Neurol. 2, 462-463 PMID: 16932606, DOI: 10.1038/ncpneuro0270

Garcia, M.L., Singleton, A.B., Hernandez, D., Ward, C.M., Evey, C., Sapp, P.A., Hardy, J., Brown, R.H., Jr., and Cleveland, D.W. (2006). Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Neurobiol. Dis. 21, 102-109 PMID: 16084104, DOI: 10.1016/j.nbd.2005.06.016

Foltz, D.R., Jansen, L.E., Black, B.E., Bailey, A.O., Yates, J.R., III, and Cleveland, D.W. (2006). The human CENP-A centromeric nucleosome-associated complex. Nat. Cell Biol. 8, 458-469 PMID: 16622419, DOI: 10.1038/ncb1397

Eymard-Pierre, E., Yamanaka, K., Haeussler, M., Kress, W., Gauthier-Barichard, F., Combes, P., Cleveland, D.W., and Boespflug-Tanguy, O. (2006). Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis. Ann. Neurol. 59, 976-980 PMID: 16718699, DOI: 10.1002/ana.20879

Dhib-Jalbut, S., Arnold, D.L., Cleveland, D.W., Fisher, M., Friedlander, R.M., Mouradian, M.M., Przedborski, S., Trapp, B.D., Wyss-Coray, T., and Yong, V.W. (2006). Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J. Neuroimmunol. 176, 198-215 PMID: 16983747, DOI: 10.1016/j.jneuroim.2006.03.027

Boillee, S., Vande, V.C., and Cleveland, D.W. (2006). ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52, 39-59 PMID: 17015226, DOI: 10.1016/j.neuron.2006.09.018

Boillee, S., Yamanaka, K., Lobsiger, C.S., Copeland, N.G., Jenkins, N.A., Kassiotis, G., Kollias, G., and Cleveland, D.W.(2006). Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312, 1389-1392 PMID: 16741123, DOI: 10.1126/science.1123511

2005

Yamanaka, K. and Cleveland, D.W. (2005). Determinants of rapid disease progression in ALS. Neurology 65, 1859-1860 PMID: 16380607, DOI: 10.1212/01.wnl.0000192717.25980.b5

Weaver, B.A. and Cleveland, D.W. (2005). Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 8, 7-12 PMID: 16023594, DOI: 10.1016/j.ccr.2005.06.011

Vande, V.C. and Cleveland, D.W. (2005). VEGF: multitasking in ALS. Nat. Neurosci. 8, 5-7 PMID: 15622408, DOI: 10.1038/nn0105-5

Miller, T.M. and Cleveland, D.W. (2005). Medicine. Treating neurodegenerative diseases with antibiotics. Science 307, 361-362 PMID: 15661995, DOI: 10.1126/science.1109027

Miller, T.M., Kaspar, B.K., Kops, G.J., Yamanaka, K., Christian, L.J., Gage, F.H., and Cleveland, D.W. (2005). Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann. Neurol. 57, 773-776 PMID: 15852369, PMCID: PMC1351126, DOI: 10.1002/ana.20453

Lobsiger, C.S., Garcia, M.L., Ward, C.M., and Cleveland, D.W. (2005). Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS. Proc. Natl. Acad. Sci. 102, 10351-10356 PMID: 16002469, PMCID: PMC1177385, DOI: 10.1073/pnas.0503862102

Mao, Y., Desai, A., and Cleveland, D.W. (2005). Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J. Cell Biol. 170, 873-880 PMID: 16144904, PMCID: PMC2171436, DOI: 10.1083/jcb.200505040

Liu, J., Shinobu, L.A., Ward, C.M., Young, D., and Cleveland, D.W. (2005). Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J. Neurochem. 93, 875-882 PMID: 15857390, DOI: 10.1111/j.1471-4159.2005.03054.x

Kops, G.J., Kim, Y., Weaver, B.A., Mao, Y., McLeod, I., Yates, J.R., III, Tagaya, M., and Cleveland, D.W. (2005). ZW10 links mitotic checkpoint signaling to the structural kinetochore. J. Cell Biol. 169, 49-60 PMID: 15824131, PMCID: PMC1351127, DOI: 10.1083/jcb.200411118

Kops, G.J., Weaver, B.A., and Cleveland, D.W. (2005). On the road to cancer: aneuploidy and the mitotic checkpoint. Nat. Rev. Cancer 5, 773-785 PMID: 16195750, DOI: 10.1038/nrc1714

Bomont, P., Maddox, P., Shah, J.V., Desai, A.B., and Cleveland, D.W. (2005). Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 24, 3927-3939 PMID: 16252009, PMCID: PMC1283947, DOI: 10.1038/sj.emboj.7600848

2004

Wang, H., Hu, X., Ding, X., Dou, Z., Yang, Z., Shaw, A.W., Teng, M., Cleveland, D.W., Goldberg, M.L., Niu, L., and Yao, X. (2004). Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J. Biol. Chem. 279, 54590-54598 PMID: 15485811, DOI: 10.1074/jbc.M407588200

Vande, V.C., Garcia, M.L., Yin, X., Trapp, B.D., and Cleveland, D.W. (2004). The neuroprotective factor Wlds does not attenuate mutant SOD1-mediated motor neuron disease. Neuromolecular. Med. 5, 193-203 PMID: 15626820, DOI: 10.1385/NMM:5:3:193

Shah, J.V., Botvinick, E., Bonday, Z., Furnari, F., Berns, M., and Cleveland, D.W. (2004). Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr. Biol. 14, 942-952 PMID: 15182667, DOI: 10.1016/j.cub.2004.05.046

Liu, J., Lillo, C., Jonsson, P.A., Vande, V.C., Ward, C.M., Miller, T.M., Subramaniam, J.R., Rothstein, J.D., Marklund, S., Andersen, P.M., Brannstrom, T., Gredal, O., Wong, P.C., Williams, D.S., and Cleveland, D.W. (2004). Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 43, 5-17 PMID: 15233913, DOI: 10.1016/j.neuron.2004.06.016

Lawrence, C.J., Dawe, R.K., Christie, K.R., Cleveland, D.W., Dawson, S.C., Endow, S.A., Goldstein, L.S., Goodson, H.V., Hirokawa, N., Howard, J., Malmberg, R.L., McIntosh, J.R., Miki, H., Mitchison, T.J., Okada, Y., Reddy, A.S., Saxton, W.M., Schliwa, M., Scholey, J.M., Vale, R.D., Walczak, C.E., and Wordeman, L. (2004). A standardized kinesin nomenclature. J. Cell Biol. 167, 19-22 PMID: 15479732, PMCID: PMC2041940, DOI: 10.1083/jcb.200408113

Kops, G.J., Foltz, D.R., and Cleveland, D.W. (2004). Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. Proc. Natl. Acad. Sci. 101, 8699-8704 PMID: 15159543, PMCID: PMC423258, DOI: 10.1073/pnas.0401142101

Bruijn, L.I., Miller, T.M., and Cleveland, D.W. (2004). Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu. Rev. Neurosci. 27, 723-749 PMID: 15217349, DOI: 10.1146/annurev.neuro.27.070203.144244

Boillee, S. and Cleveland, D.W. (2004). Gene therapy for ALS delivers. Trends Neurosci. 27, 235-238 PMID: 15111001, DOI: 10.1016/j.tins.2004.03.002

Black, B.E., Foltz, D.R., Chakravarthy, S., Luger, K., Woods, V.L., Jr., and Cleveland, D.W. (2004). Structural determinants for generating centromeric chromatin. Nature 430, 578-582 PMID: 15282608, DOI: 10.1038/nature02766

2003

Yamanaka, K., Vande, V.C., Eymard-Pierre, E., Bertini, E., Boespflug-Tanguy, O., and Cleveland, D.W. (2003). Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease. Proc. Natl. Acad. Sci. 100, 16041-16046 PMID: 14668431, PMCID: PMC307689, DOI: 10.1073/pnas.2635267100

Xia, C.H., Roberts, E.A., Her, L.S., Liu, X., Williams, D.S., Cleveland, D.W., and Goldstein,L.S. (2003). Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J. Cell Biol. 161, 55-66 PMID: 12682084, PMCID: PMC2172877, DOI: 10.1083/jcb.200301026

Weaver, B.A., Bonday, Z.Q., Putkey, F.R., Kops, G.J., Silk, A.D., and Cleveland, D.W. (2003). Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. J. Cell Biol. 162, 551-563 PMID: 12925705, PMCID: PMC2173788, DOI: 10.1083/jcb.200303167

Miller, T.M. and Cleveland, D.W. (2003). Has gene therapy for ALS arrived? Nat. Med. 9, 1256-1257 PMID: 14520369, DOI: 10.1038/nm1003-1256

Mao, Y., Abrieu, A., and Cleveland, D.W. (2003). Activating and silencing the mitotic checkpoint through CENP-E-dependent activation/inactivation of BubR1. Cell 114, 87-98 PMID: 12859900, DOI: 10.1016/s0092-8674(03)00475-6

Garcia, M.L., Lobsiger, C.S., Shah, S.B., Deerinck, T.J., Crum, J., Young, D., Ward, C.M., Crawford, T.O., Gotow, T., Uchiyama, Y., Ellisman, M.H., Calcutt, N.A., and Cleveland, D.W. (2003). NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J. Cell Biol. 163, 1011-1020 PMID: 14662745, PMCID: PMC2173620, DOI: 10.1083/jcb.200308159

Cleveland, D.W., Mao, Y., and Sullivan, K.F. (2003). Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112, 407-421 PMID: 12600307, DOI: 10.1016/s0092-8674(03)00115-6

Clement, A.M., Nguyen, M.D., Roberts, E.A., Garcia, M.L., Boillee, S., Rule, M., McMahon, A.P., Doucette, W., Siwek, D., Ferrante, R.J., Brown, R.H., Jr., Julien, J.P., Goldstein, L.S., and Cleveland, D.W. (2003). Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302, 113-117 PMID: 14526083, DOI: 10.1126/science.1086071

2002

Wataya, T., Nunomura, A., Smith, M.A., Siedlak, S.L., Harris, P.L., Shimohama, S., Szweda, L.I., Kaminski, M.A., Avila, J., Price, D.L., Cleveland, D.W., Sayre, L.M., and Perry, G. (2002). High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J. Biol. Chem. 277, 4644-4648 PMID: 11733539, DOI: 10.1074/jbc.M110913200

Subramaniam, J.R., Lyons, W.E., Liu, J., Bartnikas, T.B., Rothstein, J., Price, D.L., Cleveland, D.W., Gitlin, J.D., and Wong, P.C. (2002). Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nat. Neurosci. 5, 301-307 PMID: 11889469, DOI: 10.1038/nn823

Shah, J.V. and Cleveland, D.W. (2002). Slow axonal transport: fast motors in the slow lane. Curr. Opin. Cell Biol. 14, 58-62 PMID: 11792545, DOI: 10.1016/s0955-0674(01)00294-0

Raoul, C., Estevez, A.G., Nishimune, H., Cleveland, D.W., de Lapeyriere, O., Henderson, C.E., Haase, G., and Pettmann, B. (2002). Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations. Neuron 35, 1067-1083 PMID: 12354397, DOI: 10.1016/s0896-6273(02)00905-4

Rao, M.V., Garcia, M.L., Miyazaki, Y., Gotow, T., Yuan, A., Mattina, S., Ward, C.M., Calcutt, N.A., Uchiyama, Y., Nixon, R.A., and Cleveland, D.W. (2002). Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J. Cell Biol. 158, 681-693 PMID: 12186852, PMCID: PMC2174004, DOI: 10.1083/jcb.200202037

Putkey, F.R., Cramer, T., Morphew, M.K., Silk, A.D., Johnson, R.S., McIntosh, J.R., and Cleveland, D.W. (2002). Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev. Cell 3, 351-365 PMID: 12361599, DOI: 10.1016/s1534-5807(02)00255-1

Howland, D.S., Liu, J., She, Y., Goad, B., Maragakis, N.J., Kim, B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G., DeGennaro, L.J., Cleveland, D.W., and Rothstein, J.D. (2002). Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl. Acad. Sci. 99, 1604-1609 PMID: 11818550, PMCID: PMC122237, DOI: 10.1073/pnas.032539299

2001

Skene, J.P. and Cleveland, D.W. (2001). Hypoxia and Lou Gehrig. Nat. Genet. 28, 107-108 PMID: 11381249, DOI: 10.1038/88805

Kato, S., Nakashima, K., Horiuchi, S., Nagai, R., Cleveland, D.W., Liu, J., Hirano, A., Takikawa, M., Kato, M., Nakano, I., Sakoda, S., Asayama, K., and Ohama, E. (2001). Formation of advanced glycation end-product-modified superoxide dismutase-1 (SOD1) is one of the mechanisms responsible for inclusions common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutation, and transgenic mice expressing human SOD1 gene mutation. Neuropathology. 21, 67-81 PMID: 11304045, DOI: 10.1046/j.1440-1789.2001.00359.x

Kahana, J.A. and Cleveland, D.W. (2001). Cell cycle. Some importin news about spindle assembly. Science 291,1718-1719 PMID: 11253198, DOI: 10.1126/science.1059765

Garcia, M.L. and Cleveland, D.W. (2001). Going new places using an old MAP: tau, microtubules and human neurodegenerative disease. Curr. Opin. Cell Biol. 13, 41-48 PMID: 11163132, DOI: 10.1016/s0955-0674(00)00172-1

Cleveland, D.W. and Rothstein, J.D. (2001). From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2, 806-819 PMID: 11715057, DOI: 10.1038/35097565

Abrieu, A., Magnaghi-Jaulin, L., Kahana, J.A., Peter, M., Castro, A., Vigneron, S., Lorca, T., Cleveland, D.W., and Labbe, J.C. (2001). Mps1 is a kinetochore-associated kinase essential for the vertebrate mitotic checkpoint. Cell 106, 83-93 PMID: 11461704, DOI: 10.1016/s0092-8674(01)00410-x

2000

Yucel, J.K., Marszalek, J.D., McIntosh, J.R., Goldstein, L.S., Cleveland, D.W., and Philp, A.V. (2000). CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. J. Cell Biol. 150, 1-11 PMID: 10893249, PMCID: PMC2185570, DOI: 10.1083/jcb.150.1.1

Williamson, T.L., Corson, L.B., Huang, L., Burlingame, A., Liu, J., Bruijn, L.I., and Cleveland, D.W. (2000). Toxicity of ALS-linked SOD1 mutants. Science 288, 399 PMID: 10798964, DOI: 10.1126/science.288.5465.399a

Yao, X., Abrieu, A., Zheng, Y., Sullivan, K.F., and Cleveland, D.W. (2000). CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nat. Cell Biol. 2, 484-491 PMID: 10934468, DOI: 10.1038/35019518

Shah, J.V. and Cleveland, D.W. (2000). Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell 103, 997-1000 PMID: 11163175, DOI: 10.1016/s0092-8674(00)00202-6

Sanchez, I., Hassinger, L., Sihag, R.K., Cleveland, D.W., Mohan, P., and Nixon, R.A. (2000). Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J. Cell Biol. 151, 1013-1024 PMID: 11086003, PMCID: PMC2174358, DOI: 10.1083/jcb.151.5.1013

Price, D.L., Wong, P.C., Markowska, A.L., Lee, M.K., Thinakaren, G., Cleveland, D.W., Sisodia,S.S., and Borchelt,D.R. (2000). The value of transgenic models for the study of neurodegenerative diseases. Ann. N. Y. Acad. Sci. 920, 179-191 PMID: 11193148, DOI: 10.1111/j.1749-6632.2000.tb06920.x

Pasinelli, P., Houseweart, M.K., Brown, R.H., Jr., and Cleveland, D.W. (2000). Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. 97, 13901-13906 PMID: 11095709, PMCID: PMC17673, DOI: 10.1073/pnas.240305897

Merdes, A., Heald, R., Samejima, K., Earnshaw, W.C., and Cleveland, D.W. (2000). Formation of spindle poles by dynein/dynactin-dependent transport of NuMA. J. Cell Biol. 149, 851-862 PMID: 10811826, PMCID: PMC2174573, DOI: 10.1083/jcb.149.4.851

Kato, S., Horiuchi, S., Liu, J., Cleveland, D.W., Shibata, N., Nakashima, K., Nagai, R., Hirano, A., Takikawa, M., Kato, M., Nakano, I., and Ohama, E. (2000). Advanced glycation endproduct-modified superoxide dismutase-1 (SOD1)-positive inclusions are common to familial amyotrophic lateral sclerosis patients with SOD1 gene mutations and transgenic mice expressing human SOD1 with a G85R mutation. Acta Neuropathol. 100, 490-505 PMID: 11045671, DOI: 10.1007/s004010000226

Kato, S., Takikawa, M., Nakashima, K., Hirano, A., Cleveland, D.W., Kusaka, H., Shibata, N., Kato, M., Nakano, I., and Ohama, E. (2000). New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes. Amyotroph. Lateral. Scler. Other Motor Neuron Disord. 1, 163-184 PMID: 11464950, DOI: 10.1080/14660820050515160

Cleveland, D.W. and Liu, J. (2000). Oxidation versus aggregation - how do SOD1 mutants cause ALS? Nat. Med. 6, 1320-1321 PMID: 11100110, DOI: 10.1038/82122

Abrieu, A., Kahana, J.A., Wood, K.W., and Cleveland, D.W. (2000). CENP-E as an essential component of the mitotic checkpoint in vitro. Cell 102, 817-826 PMID: 11030625, DOI: 10.1016/s0092-8674(00)00070-2

1999

Williamson, T.L. and Cleveland, D.W. (1999). Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 2, 50-56 PMID: 10195180, DOI: 10.1038/4553

Rothstein, J.D., Dykes-Hoberg, M., Corson, L.B., Becker, M., Cleveland, D.W., Price, D.L., Culotta, V.C., and Wong, P.C. (1999). The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. J. Neurochem. 72, 422-429 PMID: 9886096, DOI: 10.1046/j.1471-4159.1999.0720422.x

Ratovitski, T., Corson, L.B., Strain, J., Wong, P., Cleveland, D.W., Culotta, V.C., and Borchelt, D.R. (1999). Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Hum. Mol. Genet. 8, 1451-1460 PMID: 10400992, DOI: 10.1093/hmg/8.8.1451

Kahana, J.A. and Cleveland, D.W. (1999). Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly. J. Cell Biol. 146, 1205-1210 PMID: 10491385, PMCID: PMC2156118, DOI: 10.1083/jcb.146.6.1205

Houseweart, M.K. and Cleveland, D.W. (1999). Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration. J. Neurosci. 19, 6446-6456 PMID: 10414973, PMCID: PMC6782803, DOI: 10.1523/JNEUROSCI.19-15-06446.1999

Houseweart, M.K. and Cleveland, D.W. (1999). Cytoskeletal linkers: new MAPs for old destinations. Curr. Biol. 9, R864-R866 PMID: 10574751, DOI: 10.1016/s0960-9822(00)80048-2

Corson, L.B., Folmer, J., Strain, J.J., Culotta, V.C., and Cleveland, D.W. (1999). Oxidative stress and iron are implicated in fragmenting vacuoles of Saccharomyces cerevisiae lacking Cu,Zn-superoxide dismutase. J. Biol. Chem. 274, 27590-27596 PMID: 10488097, DOI: 10.1074/jbc.274.39.27590

Cleveland, D.W. (1999). From Charcot to SOD1: mechanisms of selective motor neuron death in ALS. Neuron 24, 515-520 PMID: 10595505, DOI: 10.1016/s0896-6273(00)81108-3

1998

Williamson, T.L., Bruijn, L.I., Zhu, Q., Anderson, K.L., Anderson, S.D., Julien, J.P., and Cleveland, D.W. (1998). Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc. Natl. Acad. Sci. 95, 9631-9636 PMID: 9689132, PMCID: PMC21390, DOI: 10.1073/pnas.95.16.9631

Rao, M.V., Houseweart, M.K., Williamson, T.L., Crawford, T.O., Folmer, J., and Cleveland, D.W. (1998). Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J. Cell Biol. 143, 171-181 PMID: 9763429, PMCID: PMC2132801, DOI: 10.1083/jcb.143.1.171

Pasinelli, P., Borchelt, D.R., Houseweart, M.K., Cleveland, D.W., and Brown, R.H., Jr. (1998). Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc. Natl. Acad. Sci. 95, 15763-15768 PMID: 9861044, PMCID: PMC28118, DOI: 10.1073/pnas.95.26.15763

Merdes, A. and Cleveland, D.W. (1998). The role of NuMA in the interphase nucleus. J. Cell Sci. 111 ( Pt 1), 71-79 PMID: 9394013, DOI: 10.1242/jcs.111.1.71

Houseweart, M.K. and Cleveland, D.W. (1998). Intermediate filaments and their associated proteins: multiple dynamic personalities. Curr. Opin. Cell Biol. 10, 93-101 PMID: 9484600, DOI: 10.1016/s0955-0674(98)80091-4

Fuchs, E. and Cleveland, D.W. (1998). A structural scaffolding of intermediate filaments in health and disease. Science 279, 514-519 PMID: 9438837, DOI: 10.1126/science.279.5350.514

Eyer, J., Cleveland, D.W., Wong, P.C., and Peterson, A.C. (1998). Pathogenesis of two axonopathies does not require axonal neurofilaments. Nature 391, 584-587 PMID: 9468135, DOI: 10.1038/35378

Couillard-Despres, S., Zhu, Q., Wong, P.C., Price, D.L., Cleveland, D.W., and Julien, J.P. (1998). Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase. Proc. Natl. Acad. Sci. 95, 9626-9630 PMID: 9689131, PMCID: PMC21389, DOI: 10.1073/pnas.95.16.9626

Corson, L.B., Strain, J.J., Culotta, V.C., and Cleveland, D.W. (1998). Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc. Natl. Acad. Sci. 95, 6361-6366 PMID: 9600970, PMCID: PMC27707, DOI: 10.1073/pnas.95.11.6361

Bruijn, L.I., Houseweart, M.K., Kato, S., Anderson, K.L., Anderson, S.D., Ohama, E., Reaume, A.G., Scott, R.W., and Cleveland, D.W. (1998). Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science 281, 1851-1854 PMID: 9743498, DOI: 10.1126/science.281.5384.1851

Borchelt, D.R., Wong, P.C., Becher, M.W., Pardo, C.A., Lee, M.K., Xu, Z.S., Thinakaran, G., Jenkins, N.A., Copeland, N.G., Sisodia, S.S., Cleveland, D.W., Price, D.L., and Hoffman, P.N. (1998). Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice. Neurobiol. Dis. 5, 27-35 PMID: 9702785, DOI: 10.1006/nbdi.1998.0178

1997

Yao, X., Anderson, K.L., and Cleveland, D.W. (1997). The microtubule-dependent motor centromere-associated protein E (CENP-E) is an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J. Cell Biol. 139, 435-447 PMID: 9334346, PMCID: PMC2139792, DOI: 10.1083/jcb.139.2.435

Wood, K.W., Sakowicz, R., Goldstein, L.S., and Cleveland, D.W. (1997). CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment. Cell 91, 357-366 PMID: 9363944, DOI: 10.1016/s0092-8674(00)80419-5

Merdes, A. and Cleveland, D.W. (1997). Pathways of spindle pole formation: different mechanisms; conserved components. J. Cell Biol. 138, 953-956 PMID: 9281574, PMCID: PMC2136757, DOI: 10.1083/jcb.138.5.953

Duesbery, N.S., Choi, T., Brown, K.D., Wood, K.W., Resau, J., Fukasawa, K., Cleveland, D.W., and Vande Woude, G.F. (1997). CENP-E is an essential kinetochore motor in maturing oocytes and is masked during mos-dependent, cell cycle arrest at metaphase II. Proc. Natl. Acad. Sci. 94, 9165-9170 PMID: 9256453, PMCID: PMC23089, DOI: 10.1073/pnas.94.17.9165

Bruijn, L.I., Becher, M.W., Lee, M.K., Anderson, K.L., Jenkins, N.A., Copeland, N.G., Sisodia, S.S., Rothstein, J.D., Borchelt, D.R., Price, D.L., and Cleveland, D.W. (1997). ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 18, 327-338 PMID: 9052802, DOI: 10.1016/s0896-6273(00)80272-x

Bruijn, L.I., Beal, M.F., Becher, M.W., Schulz, J.B., Wong, P.C., Price, D.L., and Cleveland, D.W. (1997). Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant. Proc. Natl. Acad. Sci. 94, 7606-7611 PMID: 9207139, PMCID: PMC23869, DOI: 10.1073/pnas.94.14.7606

1996

Yang, Y., Dowling, J., Yu, Q.C., Kouklis, P., Cleveland, D.W., and Fuchs, E. (1996). An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell 86, 655-665 PMID: 8752219, DOI: 10.1016/s0092-8674(00)80138-5

Williamson, T.L., Marszalek, J.R., Vechio, J.D., Bruijn, L.I., Lee, M.K., Xu, Z., Brown, R.H., Jr., and Cleveland, D.W.(1996). Neurofilaments, radial growth of axons, and mechanisms of motor neuron disease. Cold Spring Harb. Symp. Quant. Biol. 61, 709-723 PMID: 9246497

Xu, Z., Marszalek, J.R., Lee, M.K., Wong, P.C., Folmer, J., Crawford, T.O., Hsieh, S.T., Griffin, J.W., and Cleveland, D.W.(1996). Subunit composition of neurofilaments specifies axonal diameter. J. Cell Biol. 133, 1061-1069 PMID: 8655579, PMCID: PMC2120858, DOI: 10.1083/jcb.133.5.1061

Vechio, J.D., Bruijn, L.I., Xu, Z., Brown, R.H., Jr., and Cleveland, D.W. (1996). Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis. Ann. Neurol. 40, 603-610 PMID: 8871580, DOI: 10.1002/ana.410400410

Price, D.L., Borchelt, D.R., Wong, P.C., Pardo, C.A., Thinakaran, G., Lee, M.K., Cleveland, D.W., and Sisodia, S.S. (1996). Neurodegenerative diseases and model systems. Cold Spring Harb. Symp. Quant. Biol. 61, 725-738 PMID: 9246498

Price, D.L., Koliatsos, V.E., Wong, P.C., Pardo, C.A., Borchelt, D.R., Lee, M.K., Cleveland, D.W., Griffin, J.W., Hoffman, P.N., Cork, L.C., and Sisodia, S.S. (1996). Motor neuron disease and animal models. Ciba Found. Symp. 196, 3-13

Merdes, A., Ramyar, K., Vechio, J.D., and Cleveland, D.W. (1996). A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly. Cell 87, 447-458 PMID: 8898198, DOI: 10.1016/s0092-8674(00)81365-3

Marszalek, J.R., Williamson, T.L., Lee, M.K., Xu, Z., Hoffman, P.N., Becher, M.W., Crawford, T.O., and Cleveland, D.W.(1996). Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J. Cell Biol. 135, 711-724 PMID: 8909545, PMCID: PMC2121055, DOI: 10.1083/jcb.135.3.711

Lee, M.K. and Cleveland, D.W. (1996). Neuronal intermediate filaments. Annu. Rev. Neurosci. 19, 187-217 PMID: 8833441, DOI: 10.1146/annurev.ne.19.030196.001155

Dong, D.L., Xu, Z.S., Hart, G.W., and Cleveland, D.W. (1996). Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H. J. Biol. Chem. 271, 20845-20852

Cleveland, D.W., Bruijn, L.I., Wong, P.C., Marszalek, J.R., Vechio, J.D., Lee, M.K., Xu, X.S., Borchelt, D.R., Sisodia, S.S., and Price, D.L. (1996). Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease. Neurology 47, S54-S61 PMID: 8858052, DOI: 10.1212/wnl.47.4_suppl_2.54s

Cleveland, D.W. (1996). Neuronal growth and death: order and disorder in the axoplasm. Cell 84, 663-666 PMID: 8625404, DOI: 10.1016/s0092-8674(00)81044-2

Bruijn, L.I. and Cleveland, D.W. (1996). Mechanisms of selective motor neuron death in ALS: insights from transgenic mouse models of motor neuron disease. Neuropathol. Appl. Neurobiol. 22, 373-387 PMID: 8930947, DOI: 10.1111/j.1365-2990.1996.tb00907.x

Brown, K.D., Wood, K.W., and Cleveland, D.W. (1996). The kinesin-like protein CENP-E is kinetochore-associated throughout poleward chromosome segregation during anaphase-A. J. Cell Sci. 109 ( Pt 5), 961-969 PMID: 8743943, DOI: 10.1242/jcs.109.5.961

1995

Wong, P.C., Pardo, C.A., Borchelt, D.R., Lee, M.K., Copeland, N.G., Jenkins, N.A., Sisodia, S.S., Cleveland, D.W., and Price,D.L. (1995). An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105-1116 PMID: 7605627, DOI: 10.1016/0896-6273(95)90259-7

Cleveland, D.W. (1995). NuMA: a protein involved in nuclear structure, spindle assembly, and nuclear re-formation.Trends Cell Biol. 5, 60-64 PMID: 14731413, DOI: 10.1016/s0962-8924(00)88947-3

Wong, P.C., Marszalek, J., Crawford, T.O., Xu, Z., Hsieh, S.T., Griffin, J.W., andCleveland, D.W. (1995). Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J. Cell Biol. 130, 1413-1422 PMID: 7559762, PMCID: PMC2120568, DOI: 10.1083/jcb.130.6.1413

Pardo, C.A., Xu, Z., Borchelt, D.R., Price, D.L., Sisodia, S.S., and Cleveland, D.W. (1995). Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc. Natl. Acad. Sci. 92, 954-958 PMID: 7862672, PMCID: PMC42615, DOI: 10.1073/pnas.92.4.954

Cleveland, D.W., Laing, N., Hurse, P.V., and Brown, R.H., Jr. (1995). Toxic mutants in Charcot's sclerosis. Nature 378, 342-343 PMID: 7477368, DOI: 10.1038/378342a0

Borchelt, D.R., Guarnieri, M., Wong, P.C., Lee, M.K., Slunt, H.S., Xu, .S., Sisodia, S.S., Price, D.L., and Cleveland, D.W.(1995). Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function. J. Biol. Chem. 270, 3234-3238 PMID: 7852409, DOI: 10.1074/jbc.270.7.3234

1994

Xu, Z., Dong, D.L., and Cleveland, D.W. (1994). Neuronal intermediate filaments: new progress on an old subject. Curr. Opin. Neurobiol. 4, 655-661 PMID: 7849521, DOI: 10.1016/0959-4388(94)90006-x

Price, D.L., Cleveland, D.W., and Koliatsos, V.E. (1994). Motor neurone disease and animal models. Neurobiol. Dis. 1 , 3-11 PMID: 9216981, DOI: 10.1006/nbdi.1994.0002

Lee, M.K. and Cleveland, D.W. (1994). Neurofilament function and dysfunction: involvement in axonal growth and neuronal disease. Curr. Opin. Cell Biol. 6, 34-40 PMID: 7513179, DOI: 10.1016/0955-0674(94)90113-9

Lee, M.K., Marszalek, J.R., and Cleveland, D.W. (1994). A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13, 975-988 PMID: 7946341, DOI: 10.1016/0896-6273(94)90263-1

Katz, D.A., Theodorakis, N.G., Cleveland, D.W., Lindsten, T., and Thompson, C.B. (1994). AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res. 22, 238-246 PMID: 8121809, PMCID: PMC307777, DOI: 10.1093/nar/22.2.238

Hsieh, S.T., Kidd, G.J., Crawford, T.O., Xu, Z., Lin, W.M., Trapp, B.D., Cleveland, D.W., and Griffin, J.W. (1994). Regional modulation of neurofilament organization by myelination in normal axons. J. Neurosci. 14, 6392-6401 PMID: 7965044, PMCID: PMC6577281, DOI: 10.1523/JNEUROSCI.14-11-06392.1994

Gill, S.R., Cleveland, D.W., and Schroer, T.A. (1994). Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. Mol. Biol. Cell 5, 645-654 PMID: 7949421, PMCID: PMC301080, DOI: 10.1091/mbc.5.6.645

Brown, K.D., Coulson, R.M., Yen, T.J., and Cleveland, D.W. (1994). Cyclin-like accumulation and loss of the putative kinetochore motor CENP-E results from coupling continuous synthesis with specific degradation at the end of mitosis. J. Cell Biol. 125, 1303-1312 PMID: 8207059, PMCID: PMC2290920, DOI: 10.1083/jcb.125.6.1303

Compton, D.A. and Cleveland, D.W. (1994). NuMA, a nuclear protein involved in mitosis and nuclear reformation. Curr. Opin. Cell Biol. 6, 343-346 PMID: 7917323, DOI: 10.1016/0955-0674(94)90024-8

Borchelt, D.R., Lee, M.K., Slunt, H.S., Guarnieri, M., Xu, Z.S., Wong, P.C., Brown, R.H., Jr., Price, D.L., Sisodia, S.S., and Cleveland, D.W. (1994). Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc. Natl. Acad. Sci. 91, 8292-8296 PMID: 8058797, PMCID: PMC44592, DOI: 10.1073/pnas.91.17.8292

Bachurski, C.J., Theodorakis, N.G., Coulson, R.M., and Cleveland, D.W. (1994). An amino-terminal tetrapeptide specifies cotranslational degradation of beta-tubulin but not alpha-tubulin mRNAs. Mol. Cell Biol. 14, 4076-4086 PMID: 8196646, PMCID: PMC358773, DOI: 10.1128/mcb.14.6.4076-4086.1994

1993

Xu, Z., Cork, L.C., Griffin, J.W., and Cleveland, D.W. (1993). Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 73, 23-33 PMID: 8462100, DOI: 10.1016/0092-8674(93)90157-l

Xu, Z., Cork, L.C., Griffin, J.W., and Cleveland, D.W. (1993). Involvement of neurofilaments in motor neuron disease. J. Cell Sci. Suppl 17, 101-108 PMID: 8144684, DOI: 10.1242/jcs.1993.supplement_17.15

Lee, M.K., Xu, Z., Wong, P.C., and Cleveland, D.W. (1993). Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122, 1337-1350 PMID: 8376466, PMCID: PMC2119859, DOI: 10.1083/jcb.122.6.1337

Heins, S., Wong, P.C., Muller, S., Goldie, K., Cleveland, D.W., and Aebi, U. (1993). The rod domain of NF-L determines neurofilament architecture, whereas the end domains specify filament assembly and network formation. J. Cell Biol. 123, 1517-1533 PMID: 8253847, PMCID: PMC2290863, DOI: 10.1083/jcb.123.6.1517

Dong, D.L., Xu, Z.S., Chevrier, M.R., Cotter, R.J., Cleveland, D.W., and Hart, G.W. (1993). Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J. Biol. Chem. 268, 16679-16687 PMID: 8344946

Coulson, R.M. and Cleveland, D.W. (1993). Ferritin synthesis is controlled by iron-dependent translational derepression and by changes in synthesis/transport of nuclear ferritin RNAs. Proc. Natl. Acad. Sci. 90, 7613-7617 PMID: 8356063, PMCID: PMC47192, DOI: 10.1073/pnas.90.16.7613

Compton, D.A. and Cleveland, D.W. (1993). NuMA is required for the proper completion of mitosis. J. Cell Biol. 120, 947-957 PMID: 8432734, PMCID: PMC2200084, DOI: 10.1083/jcb.120.4.947

Bertini, E.S., Eymard-Pierre, E., Boespflug-Tanguy, O., Cleveland, D.W., and Yamanaka, K. (1993). ALS2-Related Disorders

1992

Yen, T.J., Li, G., Schaar, B.T., Szilak, I., and Cleveland, D.W. (1992). CENP-E is a putative kinetochore motor that accumulates just before mitosis. Nature 359, 536-539 PMID: 1406971, DOI: 10.1038/359536a0

Theodorakis, N.G. and Cleveland, D.W. (1992). Physical evidence for cotranslational regulation of beta-tubulin mRNA degradation. Mol. Cell Biol. 12, 791-799 PMID: 1732744, PMCID: PMC364304, DOI: 10.1128/mcb.12.2.791-799.1992

Savant-Bhonsale, S. and Cleveland, D.W. (1992). Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev. 6, 1927-1939 PMID: 1398070, DOI: 10.1101/gad.6.10.1927

Joshi, H.C., Palacios, M.J., McNamara, L., and Cleveland, D.W. (1992). Gamma-tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation. Nature 356, 80-83 PMID: 1538786, DOI: 10.1038/356080a0

Compton, D.A., Szilak, I., and Cleveland, D.W. (1992). Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J. Cell Biol. 116, 1395-1408 PMID: 1541636, PMCID: PMC2289377, DOI: 10.1083/jcb.116.6.1395

Cleveland, D.W. and Hinnebusch, A.G. (1992). Post-transcriptional processes. Curr. Opin. Cell Biol. 4, 973-974

Cleveland, D.W. (1992). Forensic DNA typing. Science 255, 1052-1055

1991

Yen, T.J., Compton, D.A., Wise, D., Zinkowski, R.P., Brinkley, B.R., Earnshaw, W.C., and Cleveland, D.W (1991). CENP-E, a novel human centromere-associated protein required for progression from metaphase to anaphase. EMBO J. 10, 1245-1254 PMID: 2022189, PMCID: PMC452779, DOI: 10.1002/j.1460-2075.1991.tb08066.x

Gill, S.R., Schroer, T.A., Szilak, I., Steuer, E.R., Sheetz, M.P., and Cleveland, D.W. (1991). Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115, 1639-1650 PMID: 1836789, PMCID: PMC2289205, DOI: 10.1083/jcb.115.6.1639

Compton, D.A., Yen, T.J., and Cleveland, D.W. (1991). Identification of novel centromere/kinetochore-associated proteins using monoclonal antibodies generated against human mitotic chromosome scaffolds. J. Cell Biol. 112, 1083-1097 PMID: 1999466, PMCID: PMC2288900, DOI: 10.1083/jcb.112.6.1083

Cleveland, D.W., Monteiro, M.J., Wong, P.C., Gill, S.R., Gearhart, J.D., and Hoffman, P.N. (1991). Involvement of neurofilaments in the radial growth of axons. J. Cell Sci. Suppl 15, 85-95 PMID: 1824110, DOI: 10.1242/jcs.1991.supplement_15.12

Cleveland, D.W. and Hoffman, P.N. (1991). Slow axonal transport models come full circle: evidence that microtubule sliding mediates axon elongation and tubulin transport. Cell 67, 453-456 PMID: 1718604, DOI: 10.1016/0092-8674(91)90518-4

Cleveland, D.W. and Hoffman, P.N. (1991). Neuronal and glial cytoskeletons. Curr. Opin. Neurobiol. 1, 346-353 PMID: 1821676, DOI: 10.1016/0959-4388(91)90051-8

Cleveland, D.W. (1991). Going public. New Biol. 3, 637-640

1990

Wong, P.C. and Cleveland, D.W. (1990). Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J. Cell Biol. 111, 1987-2003 PMID: 2121743, PMCID: PMC2116320, DOI: 10.1083/jcb.111.5.1987

Sisodia, S.S., Gay, D.A., and Cleveland, D.W. (1990). In vivo discrimination among beta-tubulin isotypes: selective degradation of a type IV beta-tubulin isotype following overexpression in cultured animal cells. New Biol. 2, 66-76 PMID: 2078553

Monteiro, M.J., Hoffman, P.N., Gearhart, J.D., and Cleveland, D.W. (1990). Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J. Cell Biol. 111, 1543-1557 PMID: 2120242, PMCID: PMC2116226, DOI: 10.1083/jcb.111.4.1543

Lee, M.K., Tuttle, J.B., Rebhun, L.I., Cleveland, D.W., and Frankfurter, A. (1990). The expression and posttranslational modification of a neuron-specific beta-tubulin isotype during chick embryogenesis. Cell Motil. Cytoskeleton 17, 118-132 PMID: 2257630, DOI: 10.1002/cm.970170207

Joshi, H.C. and Cleveland, D.W. (1990). Diversity among tubulin subunits: toward what functional end? Cell Motil. Cytoskeleton 16, 159-163 PMID: 2194680, DOI: 10.1002/cm.970160302

Gill, S.R., Wong, P.C., Monteiro, M.J., and Cleveland, D.W. (1990). Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J. Cell Biol. 111, 2005-2019 PMID: 2121744, PMCID: PMC2116331, DOI: 10.1083/jcb.111.5.2005

Gabriel, A., Yen, T.J., Schwartz, D.C., Smith, C.L., Boeke, J.D., Sollner-Webb, B., and Cleveland, D.W. (1990). A rapidly rearranging retrotransposon within the miniexon gene locus of Crithidia fasciculata. Mol. Cell Biol. 10, 615-624 PMID: 2153919, PMCID: PMC360853, DOI: 10.1128/mcb.10.2.615-624.1990

D'Arpa,P., White-Cooper,H., Cleveland, D.W., Rothfield, N.F., and Earnshaw, W.C. (1990). Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl-70) recognized by sera of scleroderma patients. Arthritis Rheum. 33, 1501-1511 PMID: 1699543, DOI: 10.1002/art.1780331007

Cleveland, D.W. (1990). Microtubule MAPping. Cell 60, 701-702

Cleveland, D.W., Joshi,H.C., and Murphy,D.B. (1990). Tubulin site interpretation. Nature 344, 389 PMID: 2138712, DOI: 10.1038/344389a0

1989

Monteiro, M.J. and Cleveland, D.W. (1989). Expression of NF-L and NF-M in fibroblasts reveals coassembly ofneurofilament and vimentin subunits. J. Cell Biol. 108, 579-593 PMID: 2493000, PMCID: PMC2115435, DOI: 10.1083/jcb.108.2.579

Joshi, H.C. and Cleveland, D.W. (1989). Differential utilization of beta-tubulin isotypes in differentiating neurites. J. Cell Biol. 109, 663-673 PMID: 2503525, PMCID: PMC2115728, DOI: 10.1083/jcb.109.2.663

Gay, D.A., Sisodia, S.S., and Cleveland, D.W. (1989). Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation. Proc. Natl. Acad. Sci. 86, 5763-5767 PMID: 2762294, PMCID: PMC297710, DOI: 10.1073/pnas.86.15.5763

Cleveland, D.W. (1989). Use of DNA transfection to analyze gene regulation and function in animal cells: dissection of the tubulin multigene family. Cell Motil. Cytoskeleton 14, 147-155 PMID: 2684421, DOI: 10.1002/cm.970140125

Cleveland, D.W. (1989). Gene regulation through messenger RNA stability. Curr. Opin. Cell Biol. 1, 1148-1153 PMID: 2699801, DOI: 10.1016/s0955-0674(89)80065-1

Cleveland, D.W. (1989). Autoregulated control of tubulin synthesis in animal cells. Curr. Opin. Cell Biol. 1, 10-14 PMID: 2629858, DOI: 10.1016/s0955-0674(89)80030-4

Cleveland, D.W. and Yen, T.J. (1989). Multiple determinants of eukaryotic mRNA stability. New Biol. 1, 121-126 PMID: 2518709

1988

Yen, T.J., Gay, D.A., Pachter, J.S., and Cleveland, D.W. (1988). Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides. Mol. Cell Biol. 8, 1224-1235 PMID: 2835666, PMCID: PMC363267, DOI: 10.1128/mcb.8.3.1224-1235.1988

Yen, T.J., Machlin, P.S., andCleveland, D.W. (1988). Autoregulated instability of beta-tubulin mRNAs by recognition of the nascent amino terminus of beta-tubulin. Nature 334, 580-585 PMID: 3405308, DOI: 10.1038/334580a0

Pratt, L.F. and Cleveland, D.W. (1988). A survey of the alpha-tubulin gene family in chicken: unexpected sequence heterogeneity in the polypeptides encoded by five expressed genes. EMBO J. 7, 931-940 PMID: 3267229, PMCID: PMC454418, DOI: 10.1002/j.1460-2075.1988.tb02898.x

Monteiro, M.J. and Cleveland, D.W. (1988). Sequence of chicken c beta 7 tubulin. Analysis of a complete set of vertebrate beta-tubulin isotypes. J. Mol. Biol. 199, 439-446 PMID: 3351937, DOI: 10.1016/0022-2836(88)90616-x

Hoffman, P.N. and Cleveland, D.W. (1988). Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc. Natl. Acad. Sci. 85, 4530-4533 PMID: 3132717, PMCID: PMC280464, DOI: 10.1073/pnas.85.12.4530D

'Arpa, P., Machlin, P.S., Ratrie, H., III, Rothfield, N.F.,Cleveland, D.W., and Earnshaw, W.C. (1988). cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment. Proc. Natl. Acad. Sci. 85, 2543-2547 PMID: 2833744, PMCID: PMC280033, DOI: 10.1073/pnas.85.8.2543

Cleveland, D.W. (1988). Autoregulated instability of tubulin mRNAs: a novel eukaryotic regulatory mechanism. Trends Biochem. Sci. 13, 339-343 PMID: 3072712, DOI: 10.1016/0968-0004(88)90103-x

Banerjee, A., Roach, M.C., Wall, K.A., Lopata, M.A., Cleveland, D.W., and Luduena,R.F. (1988). A monoclonal antibody against the type II isotype of beta-tubulin. Preparation of isotypically altered tubulin. J. Biol. Chem. 263, 3029-3034 PMID: 3277964

1987

Sisodia, S.S., Sollner-Webb, B., and Cleveland, D.W. (1987). Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation. Mol. Cell Biol. 7, 3602-3612 PMID: 3683396, PMCID: PMC368014, DOI: 10.1128/mcb.7.10.3602-3612.1987

Sisodia, S.S., Cleveland, D.W., and Sollner-Webb, B. (1987). A combination of RNase H and S1 nuclease circumvents an artefact inherent to conventional S1 analysis of RNA splicing. Nucleic Acids Res. 15, 1995-2011 PMID: 3031584, PMCID: PMC340613, DOI: 10.1093/nar/15.5.1995

Pratt, L.F., Okamura, S., and Cleveland, D.W. (1987). A divergent testis-specific alpha-tubulin isotype that does not contain a coded C-terminal tyrosine. Mol. Cell Biol. 7, 552-555 PMID: 3561402, PMCID: PMC365103, DOI: 10.1128/mcb.7.1.552-555.1987

Pachter, J.S., Yen, T.J., andCleveland, D.W. (1987). Autoregulation of tubulin expression is achieved through specific degradation of polysomal tubulin mRNAs. Cell 51, 283-292 PMID: 2444342, DOI: 10.1016/0092-8674(87)90155-3

Murphy, D.B., Wallis, K.T., Machlin, P.S., Ratrie, H., III, and Cleveland, D.W. (1987). The sequence and expression of the divergent beta-tubulin in chicken erythrocytes. J. Biol. Chem. 262, 14305-14312 PMID: 2888766

Lopata, M.A. and Cleveland, D.W. (1987). In vivo microtubules are copolymers of available beta-tubulin isotypes: localization of each of six vertebrate beta-tubulin isotypes using polyclonal antibodies elicited by synthetic peptide antigens. J. Cell Biol. 105, 1707-1720 PMID: 3312237, PMCID: PMC2114651, DOI: 10.1083/jcb.105.4.1707

Joshi, H.C., Yen, T.J., and Cleveland, D.W. (1987). In vivo coassembly of a divergent beta-tubulin subunit (c beta 6) into microtubules of different function. J. Cell Biol. 105, 2179-2190 PMID: 3316249, PMCID: PMC2114845, DOI: 10.1083/jcb.105.5.2179

Hoffman, P.N., Cleveland, D.W., Griffin, J.W., Landes, P.W., Cowan, N.J., and Price, D.L. (1987). Neurofilament gene expression: a major determinant of axonal caliber. Proc. Natl. Acad. Sci. 84, 3472-3476 PMID: 3472217, PMCID: PMC304893, DOI: 10.1073/pnas.84.10.3472

Gay, D.A., Yen, T.J., Lau, J.T., and Cleveland, D.W. (1987). Sequences that confer beta-tubulin autoregulation through modulated mRNA stability reside within exon 1 of a beta-tubulin mRNA. Cell 50, 671-679 PMID: 3621343, DOI: 10.1016/0092-8674(87)90325-4

Gabriel, A., Sisodia, S.S., and Cleveland, D.W. (1987). Evidence of discontinuous transcription in the trypanosomatid Crithidia fasciculata. J. Biol. Chem. 262, 16192-16199 PMID: 3680249

Earnshaw, W.C., Machlin, P.S., Bordwell, B.J., Rothfield, N.F., and Cleveland, D.W. (1987). Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B. Proc. Natl. Acad. Sci. 84, 4979-4983 PMID: 2440036, PMCID: PMC305230, DOI: 10.1073/pnas.84.14.4979

Earnshaw, W.C., Sullivan, K.F., Machlin, P.S., Cooke, C.A., Kaiser, D.A., Pollard, T.D., Rothfield, N.F., and Cleveland, D.W.(1987). Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen. J. Cell Biol. 104, 817-829 PMID: 2435739, PMCID: PMC2114438, DOI: 10.1083/jcb.104.4.817

Cleveland, D.W. (1987). The multitubulin hypothesis revisited: what have we learned? J. Cell Biol. 104, 381-383 PMID: 3546332, PMCID: PMC2114543, DOI: 10.1083/jcb.104.3.381

1986

Sullivan, K.F. and Cleveland, D.W. (1986). Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc. Natl. Acad. Sci. 83, 4327-4331 PMID: 3459176, PMCID: PMC323725, DOI: 10.1073/pnas.83.12.4327

Sullivan, K.F., Machlin, P.S., Ratrie, H., III, and Cleveland, D.W. (1986). Sequence and expression of the chicken beta 3 tubulin gene. A vertebrate testis beta-tubulin isotype. J. Biol. Chem. 261, 13317-13322 PMID: 3759966

Sullivan, K.F., Havercroft, J.C., Machlin, P.S., and Cleveland, D.W. (1986). Sequence and expression of the chicken beta 5- and beta 4-tubulin genes define a pair of divergent beta-tubulins with complementary patterns of expression. Mol. Cell Biol. 6, 4409-4418 PMID: 3025656, PMCID: PMC367223, DOI: 10.1128/mcb.6.12.4409-4418.1986

Lopata, M.A., Cleveland, D.W., and Sollner-Webb, B. (1986). RNA polymerase specificity of mRNA production and enhancer action. Proc. Natl. Acad. Sci. 83, 6677-6681 PMID: 3462718, PMCID: PMC386572, DOI: 10.1073/pnas.83.18.6677

Lau, J.T., Pittenger, M.F., Havercroft, J.C., and Cleveland, D.W. (1986). Reconstruction of tubulin gene regulation in cultured mammalian cells. Ann. N. Y. Acad. Sci. 466, 75-88 PMID: 3460447, DOI: 10.1111/j.1749-6632.1986.tb38385.x

Cleveland, D.W. (1986). A cellular structure: the cytoskeleton. Science 233, 1436 PMID: 17830745, DOI: 10.1126/science.233.4771.1436

1985

Sullivan, K.F., Lau, J.T., and Cleveland, D.W. (1985). Apparent gene conversion between beta-tubulin genes yields multiple regulatory pathways for a single beta-tubulin polypeptide isotype. Mol. Cell Biol. 5, 2454-2465 PMID: 3837190, PMCID: PMC366973, DOI: 10.1128/mcb.5.9.2454-2465.1985

Pittenger, M.F. and Cleveland, D.W. (1985). Retention of autoregulatory control of tubulin synthesis in cytoplasts: demonstration of a cytoplasmic mechanism that regulates the level of tubulin expression. J. Cell Biol. 101, 1941-1952 PMID: 4055901, PMCID: PMC2113971, DOI: 10.1083/jcb.101.5.1941

Lopata, M.A., Sollner-Webb, B., and Cleveland, D.W. (1985). Surprising S1-resistant trimolecular hybrids: potential complication in interpretation of S1 mapping analyses. Mol. Cell Biol. 5, 2842-2846 PMID: 3016519, PMCID: PMC367024, DOI: 10.1128/mcb.5.10.2842-2846.1985

Lau, J.T., Pittenger, M.F., and Cleveland, D.W. (1985). Reconstruction of appropriate tubulin and actin gene regulation after transient transfection of cloned beta-tubulin and beta-actin genes. Mol. Cell Biol. 5, 1611-1620 PMID: 4022009, PMCID: PMC367279, DOI: 10.1128/mcb.5.7.1611-1620.1985

Cleveland, D.W. and Sullivan, K.F. (1985). Molecular biology and genetics of tubulin. Annu. Rev. Biochem. 54, 331-365 PMID: 3896122, DOI: 10.1146/annurev.bi.54.070185.001555

1984

Sullivan, K.F. and Cleveland, D.W. (1984). Sequence of a highly divergent beta tubulin gene reveals regional heterogeneity in the beta tubulin polypeptide. J. Cell Biol. 99, 1754-1760 PMID: 6490718, PMCID: PMC2113369, DOI: 10.1083/jcb.99.5.1754

Lopata, M.A., Cleveland, D.W., and Sollner-Webb, B. (1984). High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res. 12, 5707-5717 PMID: 6589587, PMCID: PMC320025, DOI: 10.1093/nar/12.14.5707

Havercroft, J.C. and Cleveland, D.W. (1984). Programmed expression of beta-tubulin genes during development and differentiation of the chicken. J. Cell Biol. 99, 1927-1935 PMID: 6094589, PMCID: PMC2113537, DOI: 10.1083/jcb.99.6.1927

1983

Milner, R.J., Brow, M.D., Cleveland, D.W., Shinnick, T.M., and Sutcliffe, J.G. (1983). Glyceraldehyde 3-phosphate dehydrogenase protein and mRNA are both differentially expressed in adult chickens but not chick embryos. Nucleic Acids Res. 11, 3301-3315 PMID: 6687938, PMCID: PMC325964, DOI: 10.1093/nar/11.10.3301

Lopata, M.A., Havercroft, J.C., Chow, L.T., and Cleveland, D.W. (1983). Four unique genes required for beta tubulin expression in vertebrates. Cell 32, 713-724 PMID: 6831558, DOI: 10.1016/0092-8674(83)90057-0

Cowan, N.J., Dobner, P.R., Fuchs, E.V., and Cleveland, D.W. (1983). Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol. Cell Biol. 3, 1738-1745 PMID: 6646120, PMCID: PMC370035, DOI: 10.1128/mcb.3.10.1738-1745.1983

Cleveland, D.W. (1983). Peptide mapping in one dimension by limited proteolysis of sodium dodecyl sulfate-solubilized proteins. Methods Enzymol. 96, 222-229 PMID: 6361454, DOI: 10.1016/s0076-6879(83)96020-2

Cleveland, D.W., Pittenger, M.F., and Lopata, M.A. (1983). Autoregulatory control of expression of alpha and beta tubulin. J. Submicrosc. Cytol. 15, 353-358 PMID: 6188853

Cleveland, D.W. and Havercroft, J.C. (1983). Is apparent autoregulatory control of tubulin synthesis nontranscriptionally regulated? J. Cell Biol. 97, 919-924 PMID: 6885926, PMCID: PMC2112582, DOI: 10.1083/jcb.97.3.919

Cleveland, D.W. (1983). The tubulins: from DNA to RNA to protein and back again. Cell 34, 330-332 PMID: 6193888, DOI: 10.1016/0092-8674(83)90366-5

Cleveland, D.W., Pittenger, M.F., and Feramisco, J.R. (1983). Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature 305, 738-740 PMID: 6633643, DOI: 10.1038/305738a0

1982

Cleveland, D.W. (1982). Treadmilling of tubulin and actin. Cell 28, 689-691 PMID: 7046949, DOI: 10.1016/0092-8674(82)90048-4

1981

Valenzuela, P., Quiroga, M., Zaldivar, J., Rutter, W.J., Kirschner, M.W., and Cleveland, D.W. (1981). Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature 289, 650-655 PMID: 7464932, DOI: 10.1038/289650a0

Fuchs, E.V., Coppock, S.M., Green, H., and Cleveland, D.W. (1981). Two distinct classes of keratin genes and their evolutionary significance. Cell 27, 75-84 PMID: 6173133, DOI: 10.1016/0092-8674(81)90362-7

Cleveland, D.W., Hughes, S.H., Stubblefield, E., Kirschner, M.W., and Varmus, H.E. (1981). Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. J. Biol. Chem. 256, 3130-3134 PMID: 6259149

Cleveland, D.W., Lopata, M.A., Sherline, P., and Kirschner, M.W. (1981). Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell 25, 537-546 PMID: 6116546, DOI: 10.1016/0092-8674(81)90072-6

1980

Sanchez, F., Natzle, J.E., Cleveland, D.W., Kirschner, M.W., and McCarthy, B.J. (1980). A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell 22, 845-854 PMID: 6780200, DOI: 10.1016/0092-8674(80)90561-9

Cleveland, D.W., Lopata, M.A., MacDonald, R.J., Cowan, N.J., Rutter, W.J., and Kirschner, M.W. (1980). Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma actin genes using specific cloned cDNA probes. Cell 20, 95-105 PMID: 6893015, DOI: 10.1016/0092-8674(80)90238-x

1979

Cleveland, D.W., Spiegelman, B.M., and Kirschner, M.W. (1979). Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J. Biol. Chem. 254, 12670-12678 PMID: 227904

1978

Connolly, J.A., Kalnins, V.I., Cleveland, D.W., and Kirschner, M.W. (1978). Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J. Cell Biol. 76, 781-786 PMID: 344329, PMCID: PMC2110001, DOI: 10.1083/jcb.76.3.781

Cleveland, D.W., Kirschner, M.W., and Cowan, N.J. (1978). Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell 15, 1021-1031 PMID: 728983, DOI: 10.1016/0092-8674(78)90286-6

1977

Connolly, J.A., Kalnins, V.I., Cleveland, D.W., and Kirschner, M.W. (1977). Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc. Natl. Acad. Sci. 74, 2437-2440 PMID: 329285, PMCID: PMC432187, DOI: 10.1073/pnas.74.6.2437

Cleveland, D.W., Fischer, S.G., Kirschner, M.W., and Laemmli, U.K. (1977). Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. J. Biol. Chem. 252, 1102-1106 PMID: 320200

Cleveland, D.W., Hwo, S.Y., and Kirschner, M.W. (1977). Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J. Mol. Biol. 116, 207-225 PMID: 599557, DOI: 10.1016/0022-2836(77)90213-3

Cleveland, D.W., Hwo, S.Y., and Kirschner, M.W. (1977). Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J. Mol. Biol. 116, 227-247 PMID: 146092, DOI: 10.1016/0022-2836(77)90214-5

1976

Witman, G.B., Cleveland, D.W., Weingarten, M.D., and Kirschner, M.W. (1976). Tubulin requires tau for growth onto microtubule initiating sites. Proc. Natl. Acad. Sci. 73, 4070-4074 PMID: 1069293, PMCID: PMC431332, DOI: 10.1073/pnas.73.11.4070