Recent Relevant Publications

Painter, C.D., Sankaranarayanan, N.V., Nagarajan, B., Mandel Clausen, T., West, A.M.V., Setiawan, N.J., Park, J., Porell, R.N., Bartels, P.L., Sandoval, D.R., Vasquez. G.J., Chute, J.P., Godula, K., Vander Kooi, C.W., Gordts, P.L.S.M., Corbett, K.D., Termini, C.M., Desai, U.R. and Esko J.D. (2024) Alteration of neuropilin-1 and heparan sulfate interaction impairs murine B16 tumor growth. ACS Biol. 19:1820-1835. PMID:39099090 PMCID:11334110

Spliid, C.B., Mehta, S., Fuster, M.M., Martino, C., Morris, C.L., Lee, N., Florentino, I., Tong, K., Liu, L., Ackermann, G., Knight, R., Esko, J.D. and De Mendoza, T.H. (2024) Diversity of human salivary heparan sulfate. Glycobiology 34, cwae084. PMID: 39361890

Chen, J.S., Esko, J.D., Walker, E., Gordts, P.L.S.M., Baxter, S.L. and Toomey, C.B. (2025) High Density Lipoproteins associate with Age-Related Macular Degeneration in the All of Us Research Program. Ophthalmology. 132:684-691. PMID:39756691.

Martino, C., Kellman, B.P., Sandoval, D.R., Clausen, T.M., Cooper, R., Benjdia, A., Soualmia, F., Clark, A.E., Garretson, A.F., Marotz, C.A., Song, S.J., Wandro, S., Zaramela, L.S., Salido, R.A., Zhu, Q., Armingol, E., Vázquez-Baeza, Y., McDonald, D., Sorrentino, J.T., Taylor, B., Belda-Ferre, P., Das, P., Ali, F., Liang, C., Zhang, Y., Schifanella, L., Covizzi, A., Lai, A., Riva, A., Basting, C., Broedlow, C.A., Havulinna, A.S., Jousilahti, P., Estaki, M., Kosciolek, T., Kuplicki, R., Victor, T.A., Paulus, M.P., Savage, K.E., Benbow, J.L., Spielfogel, E.S., Anderson, C.A.M., Martinez, M.E., Lacey, J.V. Jr., Huang, S., Haiminen, N., Parida, L., Kim, H.-C., Gilbert, J.A., Sweeney, D.A., Allard, S.M., Swafford, A.D., Cheng, S., Inoyue, M., Niiranen, T., Jain, M., Salomaa, V., Zengler, K., Klatt, N.R., Hasty, J., Berteau, O., Carlin, A.F., Esko, J.D., Lewis, N.E., and Knight, R. (2025) SARS-CoV-2 infectivity can be modulated through bacterial grooming of the glycocalyx. mBio. e0401524. PMID:39998226

Badell-Grau, R.A., Pakravesh, K., Thai, K.E., Son, F., Chen, R., Rainaldi, J., Duong, K., Losay, P., Sivakumar, A., Khare, V., Corl, A.N., Pithia, R., Tran, C., Esko, J.D. and Cherqui, S. (2025) Transplantation of wild-type hematopoietic stem and progenitor cells improves disease phenotypes in a Mucopolysaccharidosis IIIC mouse model. Cell Transplant. 34:9636897251323966. PMID:40126917.

Mayfield, J.E., Rajic, A.J., Aguilar-Calvo, P., Soldau, K., Flores, S., Lawrence, R., Choudhury, B., Ghassemian, M., Pizzo, D.P., Wagner, S.L., Danque, G.A., Sumowski, P., Hansen, L.A., Goodwill, V., Esko, J.D. and Sigurdson, C.J. (2025) Multi-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of unsubstituted glucosamine and extracellular proteins. Neuropathol Exp Neurol. 4:398. PMID:40156913

Suyama, J.A., Statum, S.M., Mohana-Borges, A.V.R., Cheng, X., Ma, Y., Esko, J.D., Anger, J.T., Chung, C.B., and Alperin, M. (2025) Novel application of T1ρ magnetic resonance imaging for noninvasive assessment of bladder hyperpermeability biomarkers: A focus on glycosaminoglycan content. Neurourol 44:1081. PMID:40320728.

Bambrick, M., Godfrey, D., Johnson, M.D., Esko, J.D., Choudhury, B., Gomez Toledo, A., Paulchakrabarti, M., Fortes, C., Staley, K.J. and Duhaime, A.C.. (2025) Release of Extracellular Matrix Components after Human Traumatic Brain Injury. eNeuro 12: 488-PMID:40494618

Yin, X., Pu, Y., Yuan, S., Pache, L., Churas, C., Weston, S., Riva, L., Simons, L.M., Cisneros, W.J., Clausen, T., Biddle, G., Doss-Gollin, S., Deming, M., De Jesus, P.D., Kim, H.N., Fuentes, D., Whitelock, J.M., Esko, J.D., Lord, M.S., Mena, I., García-Sastre, A., Hultquist, J.F., Frieman, M.B., Ideker, T., Pratt, D., Martin-Sancho, L. and Chanda, S.K.. (2025) Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection. PLoS Biol. 23:e3002738. PMID:40504864

Toomey, C.B.; Pflugmacher, S., Park, K., Pihl, J., Weiser Novak, S., Rodriguez, J., Jung, J., Hauer, J., Huang, A., Boassa, D., Handa, J.T., Astrup, T., Saraswat, M., Gordts, P.L.S.M. and Esko, J.D. (2025) Bruch’s membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration. Proc. Natl. Acad. Sci. USA, 122:e2500727122. PMID:40512794

Clausen, T.M., Weiss, R.J., Tremblay, J.R., Kellman, B.P., Coker, J., Dworkin, L.A., Rodriguez, J.P., Chang, .I.M., Chen, T., Padala, V., Karlsson, R., Song, H., Peck, K.L., Ogawa, S., Sandoval, D.R., Josh,i H.J., Wang, G., Ferguson, L.P., Bhalerao, N., Moores, A., Reya, T., Sander, M., Caffrey, T.C., Grem, J.L., Aicher, A., Heeschen, C., Le, D., Lewis, N.E., Hollingsworth, M.A., Grandgenett, P.M., Bellis, S.L., Miller, R.L., Fuster, M.M., Dawson, D.W., Engle, D.D. and Esko, J.D. (2025) Antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and suppresses pancreatic tumorigenesis. Clin. Invest.16: e184172. PMID:40924474

Toledo, A.G., Golden, GJ., Cummings, R.D., Malmstrom, J. and Esko, J.D. (2025) Endothelial glycocalyx turnover in vascular health and disease: rethinking endothelial dysfunction. Annu. Rev. Biochem. 94:561. PMID:40132227

Thacker, B.E., Thorne, K.J., Cartwright, C., Park, J., Glass, K., Chea, A., Kellman, B.P., Lewis, N.E., Wang, Z., Di Nardo, A., Sharfstein, S.T., Jeske, W., Walenga, J., Hogwood, J., Gray, E., Mulloy, B., Esko, J.D. and Glass, C.A. (2022) Multiplex genome editing of mammalian cells for producing recombinant heparin. Metab. Eng. 70:155-165. PMID:35038554

Yan, W., Cao, M., Ruan, X., Jiang, L., Lee, S., Lemanek, A., Ghassemian, M., Pizzo, D.P., Wan, Y., Qiao, Y., Chin, A.R., Duggan, E., Wang, D., Nolan, J.P., Esko, J.D., Schenk, S. and Wang, S.E. (2022) Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat. Cell. Biol. 24:793-804. PMID:35469018 PMCID:9107513

Tao, C., Makrides, N., Chuang, J.Z., Wu, Y., Brooks, S.E., Esko, J.D., Sung, C.H. and Zhang, X. (2022) Chondroitin sulfate enhances the barrier function of basement membrane assembled by heparan sulfate. Development 149:dev200569. PMID:35608020 PMCID:9107513

Tillo, M., Lamanna, W.C., Dwyer, C.A., Sandoval, D.R., Pessentheiner, A.R., Al-Azzam, N., Sarrazin, S., Gonzales, J.C., Kan, S.H., Andreyev, A.Y., Schultheis, N., Thacker, B.E., Glass, C.A., Dickson, P.I., Wang, R.Y., Selleck, S.B., Esko, J.D. and Gordts, P.L.S.M. Impaired Mitophagy in Sanfilippo A mice Causes Hypertriglyceridemia and Brown Adipose Tissue Activation. (2022) J Biol Chem. 21:102159. PMID: 35750212 PMCID:9364035

Sorrentino, J.T., Golden, G.J., Morris, C., Painter, C., Nizet, V., Campos, A.R., Smith, J.W., Karlsson, C., Malmström, J., Lewis, N.E., Esko, J.D. and Toledo, A.G. (2022) Vascular proteome responses precede organ dysfunction in a murine model of Staphylococcus aureus bacteremia (2022) mSystems 7:e0039522. PMID:35913192 PMCID:9426442

Al Nakouzi, N., Wang, C., Oo, H.Z., Nelepcu, I., Lallous, N., Spliid, C., Khazamipour, N., Lo, J., Truong, S., Collins, C., Hui, D., Esfandnia, S., Adomat, H., Mandel-Clausen, T., Gustavsson, T., Choudhary, S., Dagil, R., Corey, E., Wang, Y., Chauchereau, A., Fazli, L., Esko, J., Salanti, A., Nelson, P., Gleave, M. and Daugaard, M. (2022) Reformation of the chondroitin sulfate glycocalyx enables progression of AR-independent prostate cancer Nat. Commun. 13:4760. PMID:35963852 PMCID:9376089

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling (2022) Biering, S.B., Gomes de Sousa, F.T., Tjang, L.V., Pahmeier, F., Zhu, C., Ruan, R., Blanc, S.F., Patel, T.S., Worthington, C.M., Glasner, D.R., Castillo-Rojas, B., Servellita, V., Lo, N.T.N., Wong, M.P., Warnes, C.M., Sandoval, D.R., Clausen, T.M., Santos, Y.A., Fox, D.M., Ortega, V., Näär, A.M., Baric, R.S., Stanley, S,A., Aguilar, H.C., Esko, J.D., Chiu, C.Y., Pak, J.E., Beatty, P.R. and Harris, E. Nat. Commun. 13:7630. PMID:36494335 PMCID:PMC9734751

Sørensen, D., Büll, C., Madsen, T., Lira-Navarrete, E., Clausen, T., Clark, A., Garretson, A., Karlsson, R., Pijnenborg, J., Yin, X., Miller, R., Chanda, S., Boltje, T., Schjoldager, K., Vakhrushev, S., Halim, A., Esko, J.D., Carlin, A., Hurtado-Guerrero, R., Weigert, R., Clausen, H. and Narimatsu, Y. (2023) Identification of global inhibitors of cellular glycosylation. Nat. Commun. 14:948. PMID:36804936 PMCID:9941569

Wang, X., Ramos, R., Phan, A.Q., Yamaga, K., Flesher, J.L., Jiang, S., Oh, J.W., Jin, S., Jahid, S., Kuan, C.H., Nguyen, T.K., Liang, H.Y., Shettigar. N.U., Hou, R., Tran, K.H., Nguyen, A., Vu, K.N., Phung, J.L., Ingal, J.P., Levitt, K.M., Cao, X., Liu, Y., Deng, Z., Taguchi, N., Scarfone, V.M., Wang, G., Paolilli, K.N., Wang, X., Guerrero-Juarez, C.F., Davis, R.T., Greenberg, E.N., Ruiz-Vega, R., Vasudeva, P., Murad, R., Widyastuti, L.H.P., Lee, H.L., McElwee, K.J., Gadeau, A.P., Lawson, D.A., Andersen, B., Mortazavi, A., Yu, Z., Nie, Q., Kunisada, T., Karin, M., Tuckermann, J., Esko, J.D., Ganesan, A.K., Li, J. and Plikus, M.V. (2023) Signalling by senescent melanocytes hyperactivates hair growth Nature 618:808-817. PMID: 37344645

Pihl, J., Clausen, T.M., Zhou, J., Krishnan, N., Ørum-Madsen, M.S., Gustavsson, T., Dagil. R., Daugaard, M., Choudhary, S., Foged, C., Esko, J.D., Zhang, L., Fang, R.H. and Salanti, A. (2023) Malaria biomimetic for tumor targeted drug delivery. ACS Nano. 17:13500-13509. PMID: 37435892

Aguilar-Calvo, P., Malik, A., Sandoval, D.R., Barback, C., Orrù, C.D., Standke, H.G., Thomas, O.R., Dwyer, C.A., Pizzo, D.P., Bapat, J., Soldau, K., Ogawa, R., Riley, M.B., Nilsson, K.P.R., Kraus, A., Caughey, B., Iliff, J.J., Vera, D.R., Esko, J.D. and Sigurdson, C.J. (2023) Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection. PLoS Pathog. 19:e1011487. PMID:37747931

Toledo, A.G., Bratanis, E., Velásquez, E., Chowdhury, S., Olofsson, B., Sorrentino, J.T., Karlsson, C., Lewis, N.E., Esko, J.D., Collin, M., Shannon, O., Malmström, J. (2023) Pathogen-driven degradation of endogenous and therapeutic antibodies during streptococcal infections. Nat. Commun. 14:6693. PMID:37872209

Sreekumar, A., Lu, M., Choudhury, B., Pan, T.C., Pant, D.K., Lawrence-Paul, M.R., Sterner, C.J., Belka, G.K., Toriumi, T., Benz, B.A., Escobar-Aguirre, M., Marino, F.E., Esko, J.D. and Chodosh. L.A. (2023) B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling. Cancer Cell. S1535-6108(23)00399-9.PMID: 38065100