A genome is more than just an abstract sequence of nucleotides — it is a collection of DNA molecules packaged inside of our cells. Epigenomic technologies allow us to look beyond the genome sequence, revealing information about how the genome actually exists in individual cells: bound by proteins, modified by enzymes, and folded inside the dynamic 3-dimensional space of the cell's nucleus. This epigenetic information is critical for understanding how each cell type in the human body functions during normal development, and how their function goes awry in disease.
Technologies
Current research at the Center for Epigenomics explores the function of multiple aspects of the epigenome in the context of human biology and disease — these aspects include chromatin accessibility, transcription factor binding, histone modification, and 3D chromatin architecture, in both bulk samples and in single cell resolution.
The Epigenomics Platform
This Platform is a cutting-edge research laboratory specializing in high-throughput genomic and epigenomic data generation, with a primary focus on human tissue biopsies and clinical samples.
Single-cell Epigenomics Platform
This Platform uses state-of-the-art single cell multiomic sequencing methods to resolve the cellular heterogeneity of the epigenome, transcriptome, and 3D genome architecture.
Functional & Spatial Epigenomics Platform
This Platform specializes in advanced epigenomic technologies designed to explore gene expression in healthy tissue, uncover spatial patterns in disease, or identify potential therapeutic targets.