.
Lungmap 2.0 maps the epigenome of diverse cells of the human lung
The human lungs comprise an intricate network of epithelial, mesenchymal, endothelial, and hematopoietic cells. These diverse cell types come together to form the cellular niches that collectively regulate lung function in health and disease ...
Full StoryEpigenomic atlas answers questions about islet cell heterogeneity in type 2 diabetes
Type 2 diabetes (T2D) is a complex, multifactorial disease characterized by uncontrolled blood glucose levels. It occurs when beta cells, the insulin-producing cells of the pancreatic islet, fail to produce insulin and eventually die ...
Full StoryMassive chromatin accessibility atlas provides comprehensive framework for interpreting molecular disease mechanisms
The Center has generated hundreds of single-cell resolved epigenomic atlases. But none compares to one of their most recent ones: a massive chromatin accessibility map of 472,373 cells spanning 25 adult human tissues ...
Full StorySingle-nucleus epigenomic atlas provides roadmap for understanding heart disease
Many cardiovascular disease (CVD) risk variants lie in noncoding sequences, yet little is known about how such variants participate in the development of CVD. A major reason for this is the lack of single cell-resolved generegulatory maps of the heart ...
Full StoryCollaboration takes aim at computational challenges in single-cell epigenomics
Single-cell epigenomic technologies promise fresh insight into the biology of human disease. But before this promise can be realized, one question must be answered: How do you draw meaningful conclusions from gargantuan single-cell epigenomic datasets?
Full StoryLaying the groundwork for a new understanding of the human brain
The brain is an immensely complex organ. Some 80 billion neurons form the trillions of connections that ultimately give rise to our every thought, memory, and behavior ...
Full Story