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Department of Cellular & Molecular Medicine CMM
  1. Department of Cellular and Molecular Medicine
  2. Research
  3. Labs
  4. Ghosh Lab
  5. Publications

Publications

Why publish consistently?

Full list of publications on PubMed

Complete list of releases on BioRxiv

Coupling of NOD2 to GIV is Required for Bacterial Sensing
Gajanan D. Katkar, Mahitha Shree Anandachar, Saptarshi Sinha, Stella-Rita Ibeawuchi, Celia R. Espinoza, Jane Coates, Yashaswat S. Malhotra, Madhubanti Mullick, Vanessa Castillo, Daniella T. Vo, Debashis Sahoo, Pradipta Ghosh
bioRxiv 2022.04.26.489574; doi: https://doi.org/10.1101/2022.04.26.489574

Chronologically listed from Jan 1 - Jan 1 for each year.

2024–2025:

  1. Sinha S, Farfel A, Luker KE, Parker BA, Yeung KT, Luker GD, Ghosh P. Growth signaling autonomy in circulating tumor cells aids metastatic seeding. PNAS Nexus. 2024 Jan 25;3(2):pgae014. doi: 10.1093/pnasnexus/pgae014. PMID: 38312224; PMCID: PMC10833458.
  2. Mukherjee R, Sinha S, Luker GD, Ghosh P. Interlinked switch circuits of biological intelligence. Trends Biochem Sci. 2024 Feb 9:S0968-0004(24)00020-3. doi: 10.1016/j.tibs.2024.01.006. Epub ahead of print. PMID: 38341333.

2023–2024:

  1. Abd El-Hafeez AA, Sun N, Chakraborty A, Ear J, Roy S, Chamarthi P, Rajapakse N, Das S, Luker KE, Hazra TK, Luker GD, Ghosh P. Regulation of DNA damage response by trimeric G-proteins. iScience. 2023 Jan 13;26(2):105973. doi: 10.1016/j.isci.2023.105973. PMID: 36756378; PMCID: PMC9900518.
  2. Qiao L, Ghosh P, Rangamani P. Design principles of improving the dose- response alignment in coupled GTPase switches. NPJ Syst Biol Appl. 2023 Jan 31;9(1):3. doi: 10.1038/s41540-023-00266-9. PMID: 36720885; PMCID: PMC9889403.
  3. Guven, O., Ciftci, H., Tateishi, H., Koga, R., Radwan, M. O., Sever, B., Inoue, J., Otsuka, M., Fujita, M., & DeMirci, H. (2023). Structural Characterization of TRAF6 N-terminal for Therapeutic Uses. bioRxiv 2023.02.25.529911; doi: https://doi.org/10.1101/2023.02.25.529911
  4. Qiao L, Sinha S, Abd El-Hafeez AA, Lo IC, Midde KK, Ngo T, Aznar N, Lopez- Sanchez I, Gupta V, Farquhar MG, Rangamani P, Ghosh P. A circuit for secretion- coupled cellular autonomy in multicellular eukaryotic cells. Mol Syst Biol. 2023 Apr 12;19(4):e11127. doi: 10.15252/msb.202211127. Epub 2023 Mar 1. PMID: 36856068; PMCID: PMC10090951.
  5. Tindle, C., Katkar, G. D., Fonseca, A. G., Taheri, S., Lee, J., Maity, P., Sayed, I. M., Ibeawuchi, S., Vidales, E., Pranadinata, R. F., Fuller, M., Stec, D. L., Anandachar, M. S., Perry, K., Le, H. N., Ear, J., Boland, B. S., Sandborn, W. J., Sahoo, D., Das, S., & Ghosh, P. (2023). A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics. bioRxiv 2023.03.11.532245; doi: https://doi.org/10.1101/2023.03.11.532245
  6. Tindle C, Katkar GD, Fonseca AG, Taheri S, Lee J, Maity P, Sayed IM, Ibeawuchi SR, Vidales E, Pranadinata RF, Fuller M, Stec DL, Anandachar MS, Perry K, Le HN, Ear J, Boland BS, Sandborn WJ, Sahoo D, Das S, Ghosh P. A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics. bioRxiv [Preprint]. 2023 Mar 13:2023.03.11.532245. doi: 10.1101/2023.03.11.532245. PMID: 36993763; PMCID: PMC10054961.
  7. Sinha, S., Callow, B. W., Farfel, A. P., Roy, S., Chen, S., Rajendran, S., Buschhaus, J. M., Luker, K. E., Ghosh, P., & Luker, G. D. (2023). A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels. bioRxiv 2023.03.18.533175; doi: https://doi.org/10.1101/2023.03.18.533175
  8. Sinha S, Callow BW, Farfel AP, Roy S, Chen S, Rajendran S, Buschhaus JM, Luker KE, Ghosh P, Luker GD. A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor- Stroma Tunnels. bioRxiv [Preprint]. 2023 Mar 24:2023.03.18.533175. doi: 10.1101/2023.03.18.533175. PMID: 36993616; PMCID: PMC10055300.
  9. Vo D, Ghosh P, Sahoo D. Artificial intelligence-guided discovery of gastric cancer continuum. Gastric Cancer. 2023 Mar;26(2):286-297. doi: 10.1007/s10120-022-01360-3. Epub 2023 Jan 24. PMID: 36692601; PMCID: PMC9871434.
  10. Anandachar, M. S., Roy, S., Sinha, S., Boadi, A., Ibeawuchi, S., Gementera, H., Amamoto, A., Katkar, G. D., & Ghosh, P. (2023). Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism. bioRxiv 2023.04.09.536168; doi: https://doi.org/10.1101/2023.04.09.536168
  11. Turner MA, Cox KE, Liu S, Neel N, Amirfakhri S, Nishino H, Hosseini M, Alcantara JA, Abd El-Hafeez AA, Lwin TM, Mallya K, Pisegna JR, Singh SK, Ghosh P, Hoffman RM, Batra SK, Bouvet M. Specific Targeting and Labeling of Colonic Polyps in <i>CPC-APC</i> Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer. Curr Issues Mol Biol. 2023 Apr 11;45(4):3347-3358. doi: 10.3390/cimb45040219. PMID: 37185743; PMCID: PMC10136452.
  12. Zage PE, Huo Y, Subramonian D, Le Clorennec C, Ghosh P, Sahoo D. Identification of a novel gene signature for neuroblastoma differentiation using a Boolean implication network. Genes Chromosomes Cancer. 2023 Jun;62(6):313-331. doi: 10.1002/gcc.23124. Epub 2023 Feb 13. PMID: 36680522; PMCID: PMC10257350.
  13. Zhao, X., Lempke, S. L., Urbán Arroyo, J. C., Yin, B., Holness, N. K., Smiley, J., & Ewald, S. E. (2023). Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated T. gondii restriction in murine macrophages via vacuole nitration and intravacuolar network collapse. bioRxiv 2023.07.24.549965; doi: https://doi.org/10.1101/2023.07.24.549965
  14. Ghosh P, Sinha S, Katkar GD, Vo D, Taheri S, Dang D, Das S, Sahoo D. Machine learning identifies signatures of macrophage reactivity and tolerance that predict disease outcomes. EBioMedicine. 2023 Aug;94:104719. doi: 10.1016/j.ebiom.2023.104719. Epub 2023 Jul 27. PMID: 37516087; PMCID: PMC10388732.
  15. Dadlani, E., Dash, T., & Sahoo, D. (2023). An AI-assisted Investigation of Tumor-Associated Macrophages and their Polarization in Colorectal Cancer. bioRxiv 2023.08.01.551559; doi: https://doi.org/10.1101/2023.08.01.551559
  16. Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, Jonghe S, Narayanan A, Einav S. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects. bioRxiv [Preprint]. 2023 May 10:2021.05.15.444128. doi: 10.1101/2021.05.15.444128. Update in: J Clin Invest. 2023 Aug 15;: PMID: 34159337; PMCID: PMC8219101.
  17. Kang M, Jeong S, An J, Park S, Nam S, Kwon KA, Sahoo D, Ghosh P, Kim JH. Clinicopathologic Significance of Heat Shock Protein 60 as a Survival Predictor in Colorectal Cancer. Cancers (Basel). 2023 Aug 11;15(16):4052. doi: 10.3390/cancers15164052. PMID: 37627080; PMCID: PMC10452225.
  18. Anandachar MS, Roy S, Sinha S, Agyekum B, Ibeawuchi SR, Gementera H, Amamoto A, Katkar GD, Ghosh P. Diverse Gut Pathogens Exploit the Host Engulfment Pathway via a Conserved Mechanism. bioRxiv [Preprint]. 2023 Aug 27:2023.04.09.536168. doi: 10.1101/2023.04.09.536168. Update in: J Biol Chem. 2023 Oct 25;:105390. PMID: 37066267; PMCID: PMC10104235.
  19. Hernandez JE, Llorente C, Ma S, Miyamoto KT, Sinha S, Steele S, Xiao Z, Lai CJ, Zuniga EI, Ghosh P, Schnabl B, Huang WJM. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Life Sci Alliance. 2023 Sep 4;6(11):e202302026. doi: 10.26508/lsa.202302026. PMID: 37666668; PMCID: PMC10477432.
  20. Sinha, S., Alcantara, J., Perry, K., Castillo, V., Espinoza, C. R., Taheri, S., Vidales, E., Tindle, C., Adel, A., Amirfakhri, S., Sawires, J. R., Yang, J., Bouvet, M., Sahoo, D., & Ghosh, P. (2023). Network-guided Therapeutics to Differentiate Colorectal Cancer Stem Cells. bioRxiv 2023.09.13.557628; doi: https://doi.org/10.1101/2023.09.13.557628
  21. Pepanian A, Binbay FA, Roy S, Nubbemeyer B, Koley A, Rhodes CA, Ammer H, Pei D, Ghosh P, Imhof D. Bicyclic Peptide Library Screening for the Identification of Gαi Protein Modulators. J Med Chem. 2023 Sep 14;66(17):12396-12406. doi: 10.1021/acs.jmedchem.3c00873. Epub 2023 Aug 16. PMID: 37587416.
  22. Sinha S, Alcantara J, Perry K, Castillo V, Espinoza CR, Taheri S, Vidales E, Tindle C, Adel A, Amirfakhri S, Sawires JR, Yang J, Bouvet M, Sahoo D, Ghosh P. Network-guided Therapeutics to Differentiate Colorectal Cancer Stem Cells. bioRxiv [Preprint]. 2023 Sep 21:2023.09.13.557628. doi: 10.1101/2023.09.13.557628. PMID: 37745574; PMCID: PMC10515918.
  23. Saul S, Karim M, Ghita L, Huang PT, Chiu W, Durán V, Lo CW, Kumar S, Bhalla N, Leyssen P, Alem F, Boghdeh NA, Tran DH, Cohen CA, Brown JA, Huie KE, Tindle C, Sibai M, Ye C, Khalil AM, Chiem K, Martinez-Sobrido L, Dye JM, Pinsky BA, Ghosh P, Das S, Solow-Cordero DE, Jin J, Wikswo JP, Jochmans D, Neyts J, De Jonghe S, Narayanan A, Einav S. Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects. J Clin Invest. 2023 Oct 2;133(19):e169510. doi: 10.1172/JCI169510. PMID: 37581931; PMCID: PMC10541190.
  24. Cox KE, Turner MA, Amirfakhri S, Lwin TM, Hosseini M, Ghosh P, Obonyo M, Murakami T, Hoffman RM, Yazaki PJ, Bouvet M. Humanized Anti-Carcinoembryonic Antigen Antibodies Brightly Target and Label Gastric Cancer in Orthotopic Mouse Models. J Surg Res. 2024 Jan;293:701-708. doi: 10.1016/j.jss.2023.08.038. Epub 2023 Oct 14. PMID: 37839102.
  25. Anandachar MS, Roy S, Sinha S, Boadi A, Katkar GD, Ghosh P. Diverse gut pathogens exploit the host engulfment pathway via a conserved mechanism. J Biol Chem. 2023 Oct 27;299(12):105390. doi: 10.1016/j.jbc.2023.105390. Epub ahead of print. PMID: 37890785; PMCID: PMC10696401.
  26. Iqbal K, Sinha S, David P, De Marco G, Taheri S, McLaren E, Maisuria S, Arumugakani G, Ash Z, Buckley C, Coles L, Hettiarachchi C, Smithson G, Slade M, Shah R, Marzo-Ortega H, Keen M, Lawson C, Mclorinan J, Nizam S, Reddy H, Sharif O, Sultan S, Tran G, Wood M, Wood S, Ghosh P, McGonagle D. MDA5-autoimmunity and Interstitial Pneumonitis Contemporaneous with the COVID-19 Pandemic (MIP-C). medRxiv [Preprint]. 2023 Nov 5:2023.11.03.23297727. doi: 10.1101/2023.11.03.23297727. PMID: 37961408; PMCID: PMC10635254.
  27. Katkar G, Ghosh P. Macrophage states: there's a method in the madness. Trends Immunol. 2023 Dec;44(12):954-964. doi: 10.1016/j.it.2023.10.006. Epub 2023 Nov PMID: 37945504.
  28. Tapryal N, Chakraborty A, Saha K, Islam A, Pan L, Hosoki K, Sayed IM, Duran JM, Alcantara J, Castillo V, Tindle C, Sarker AH, Wakamiya M, Cardenas VJ, Sharma G, Crotty Alexander LE, Sur S, Sahoo D, Ghosh G, Das S, Ghosh P, Boldogh I, Hazra TK. The DNA glycosylase NEIL2 is protective during SARS-CoV- infection. Nat Commun. 2023 Dec 9;14(1):8169. doi: 10.1038/s41467-023-43938-0. PMID: 38071370; PMCID: PMC10710473.
  29. Sinha S, Farfel A, Luker KE, Parker BA, Yeung KT, Luker GD, Ghosh P. Growth signaling autonomy in circulating tumor cells aids metastatic seeding. PNAS Nexus. 2024 Jan 25;3(2):pgae014. doi: 10.1093/pnasnexus/pgae014. PMID: 38312224; PMCID: PMC10833458.
  30. Mukherjee R, Sinha S, Luker GD, Ghosh P. Interlinked switch circuits of biological intelligence. Trends Biochem Sci. 2024 Feb 9:S0968-0004(24)00020-3. doi: 10.1016/j.tibs.2024.01.006. Epub ahead of print. PMID: 38341333.

2022–2023:

  1. Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC Jr, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. Cell Mol Gastroenterol Hepatol. 2022 Apr 1:S2352-345X(22)00060-1. doi: 10.1016/j.jcmgh.2022.03.008. Epub ahead of print. PMID: 35378331.
  2. Katkar GD, Sayed IM, Anandachar MS, Castillo V, Vidales E, Toobian D, Usmani F, Sawires JR, Leriche G, Yang J, Sandborn WJ, Das S, Sahoo D, Ghosh P. Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease. Commun Biol. 2022 Mar 14;5(1):231. doi: 10.1038/s42003-022-03168-4. PMID: 35288651; PMCID: PMC8921270.
  3. Elbadawi MM, Eldehna WM, Abd El-Hafeez AA, Somaa WR, Albohy A, Al-Rashood ST, Agama KK, Elkaeed EB, Ghosh P, Pommier Y, Abe M. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37(1):349-372. doi: 10.1080/14756366.2021.2015344. Erratum in: J Enzyme Inhib Med Chem. 2022 Dec;37(1):514. PMID: 34923887; PMCID: PMC8725837.
  4. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P. EBioMedicine. 2022 Aug;82:104185. doi: 10.1016/j.ebiom.2022.104185. Epub 2022 Jul 20. PMID: 35870428
  5. The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection. Hazra T, Tapryal N, Chakraborty A, Rayavara K, Wakamiya M, Islam A, Pan L, Hsu J, Tat V, Maruyama J, Hosoki K, Sayed I, Alcantara J, Castillo V, Tindle C, Sarker A, Cardenas V, Sharma G, Alexander LC, Sur S, Ghosh G, Paessler S, Sahoo D, Ghosh P, Das S, Boldogh I, Tseng CT. Res Sq. 2022 May 27:rs.3.rs-1690354. doi: 10.21203/rs.3.rs-1690354/v1. Preprint. PMID: 35665009
  6. Ghosh P, Katkar GD, Shimizu C, Kim J, Khandelwal S, Tremoulet AH, Kanegaye JT; Pediatric Emergency Medicine Kawasaki Disease Research Group. An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nat Commun. 2022 May 16;13(1):2687. doi: 10.1038/s41467-022-30357-w. PMID: 35577777
  7. New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization. Mohammed HHH, Abd El-Hafeez AA, Ebeid K, Mekkawy AI, Abourehab MAS, Wafa EI, Alhaj-Suliman SO, Salem AK, Ghosh P, Abuo-Rahma GEA, Hayallah AM, Abbas SH. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1346-1363. doi:10.1080/14756366.2022.2072308. PMID: 35548854
  8. "Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen-receptor-positive breast cancer" by Gary Luker, Johanna Buschhaus, Shrila Rajendran, Brock Humphries, Alyssa Cutter, Ayşe Muñiz, Nicholas Ciavattone, Alexander Buschhaus, Tatiana Cañeque, Zeribe Nwosu, Debashis Sahoo, Avinash Bevoor, Yatrik Shah, Costas Lyssiotis, Pradipta Ghosh, Max Wicha, and Raphaël Rodriguez [Accepted, In Press, Oncogene; 2022; Paper #ONC-2022-00536RR],
  9. Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer. Akl L, Abd El-Hafeez AA, Ibrahim TM, Salem R, Marzouk HMM, El-Domany RA, Ghosh P, Eldehna WM, Abou-Seri SM. Eur J Med Chem. 2022 Dec 5;243:114704. doi: 10.1016/j.ejmech.2022.114704. Epub 2022 Aug 31. PMID: 36095992
  10. Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer. Abdelsalam EA, Abd El-Hafeez AA, Eldehna WM, El Hassab MA, Marzouk HMM, Elaasser MM, Abou Taleb NA, Amin KM, Abdel-Aziz HA, Ghosh P, Hammad SF. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2265-2282. doi: 10.1080/14756366.2022.2104841. PMID: 36000167
  11. AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas. Ghosh P, Campos VJ, Vo DT, Guccione C, Goheen-Holland V, Tindle C, Mazzini GS, He Y, Alexandrov LB, Lippman SM, Gurski RR, Das S, Yadlapati R, Curtius K, Sahoo D. JCI Insight. 2022 Sep 22;7(18):e161334. doi: 10.1172/jci.insight.161334. PMID: 36134663
  12. Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC Jr, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. Cell Mol Gastroenterol Hepatol. 2022 Apr 1:S2352-345X(22)00060-1. doi: 10.1016/j.jcmgh.2022.03.008. Epub ahead of print. PMID: 35378331.
  13. Katkar GD, Sayed IM, Anandachar MS, Castillo V, Vidales E, Toobian D, Usmani F, Sawires JR, Leriche G, Yang J, Sandborn WJ, Das S, Sahoo D, Ghosh P. Artificial intelligence-rationalized balanced PPARα/γ dual agonism resets dysregulated macrophage processes in inflammatory bowel disease. Commun Biol. 2022 Mar 14;5(1):231. doi: 10.1038/s42003-022-03168-4. PMID: 35288651; PMCID: PMC8921270.
  14. Elbadawi MM, Eldehna WM, Abd El-Hafeez AA, Somaa WR, Albohy A, Al-Rashood ST, Agama KK, Elkaeed EB, Ghosh P, Pommier Y, Abe M. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights. J Enzyme Inhib Med Chem. 2022 Dec;37(1):349-372. doi: 10.1080/14756366.2021.2015344. Erratum in: J Enzyme Inhib Med Chem. 2022 Dec;37(1):514. PMID: 34923887; PMCID: PMC8725837.
  15. COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P. EBioMedicine. 2022 Aug;82:104185. doi: 10.1016/j.ebiom.2022.104185. Epub 2022 Jul 20. PMID: 35870428
  16. The DNA glycosylase NEIL2 plays a vital role in combating SARS-CoV-2 infection. Hazra T, Tapryal N, Chakraborty A, Rayavara K, Wakamiya M, Islam A, Pan L, Hsu J, Tat V, Maruyama J, Hosoki K, Sayed I, Alcantara J, Castillo V, Tindle C, Sarker A, Cardenas V, Sharma G, Alexander LC, Sur S, Ghosh G, Paessler S, Sahoo D, Ghosh P, Das S, Boldogh I, Tseng CT. Res Sq. 2022 May 27:rs.3.rs-1690354. doi: 10.21203/rs.3.rs-1690354/v1. Preprint. PMID: 35665009
  17. Ghosh P, Katkar GD, Shimizu C, Kim J, Khandelwal S, Tremoulet AH, Kanegaye JT; Pediatric Emergency Medicine Kawasaki Disease Research Group. An Artificial Intelligence-guided signature reveals the shared host immune response in MIS-C and Kawasaki disease. Nat Commun. 2022 May 16;13(1):2687. doi: 10.1038/s41467-022-30357-w. PMID: 35577777
  18. New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization. Mohammed HHH, Abd El-Hafeez AA, Ebeid K, Mekkawy AI, Abourehab MAS, Wafa EI, Alhaj-Suliman SO, Salem AK, Ghosh P, Abuo-Rahma GEA, Hayallah AM, Abbas SH. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1346-1363. doi: 10.1080/14756366.2022.2072308. PMID: 35548854
  19. "Effects of iron modulation on mesenchymal stem cell-induced drug resistance in estrogen-receptor-positive breast cancer" by Gary Luker, Johanna Buschhaus, Shrila Rajendran, Brock Humphries, Alyssa Cutter, Ayşe Muñiz, Nicholas Ciavattone, Alexander Buschhaus, Tatiana Cañeque, Zeribe Nwosu, Debashis Sahoo, Avinash Bevoor, Yatrik Shah, Costas Lyssiotis, Pradipta Ghosh, Max Wicha, and Raphaël Rodriguez [Accepted, In Press, Oncogene; 2022; Paper #ONC-2022-00536RR],
  20. Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer. Akl L, Abd El-Hafeez AA, Ibrahim TM, Salem R, Marzouk HMM, El-Domany RA, Ghosh P, Eldehna WM, Abou-Seri SM. Eur J Med Chem. 2022 Dec 5;243:114704. doi: 10.1016/j.ejmech.2022.114704. Epub 2022 Aug 31. PMID: 36095992
  21. Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer. Abdelsalam EA, Abd El-Hafeez AA, Eldehna WM, El Hassab MA, Marzouk HMM, Elaasser MM, Abou Taleb NA, Amin KM, Abdel-Aziz HA, Ghosh P, Hammad SF. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2265-2282. doi: 10.1080/14756366.2022.2104841. PMID: 36000167
  22. AI-assisted discovery of an ethnicity-influenced driver of cell transformation in esophageal and gastroesophageal junction adenocarcinomas. Ghosh P, Campos VJ, Vo DT, Guccione C, Goheen-Holland V, Tindle C, Mazzini GS, He Y, Alexandrov LB, Lippman SM, Gurski RR, Das S, Yadlapati R, Curtius K, Sahoo D. JCI Insight. 2022 Sep 22;7(18):e161334. doi: 10.1172/jci.insight.161334. PMID: 36134663
  23. Roy, S., Sinha, S., Silas, A. J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2023). Phosphorylation of Gαi shapes canonical Gα(i)βγ/GPCR signaling. bioRxiv, (), 2022.09.11.507491. https://doi.org/10.1101/2022.09.11.507491.
  24. Sinha, S., Farfel, A., Luker, K. E., Parker, B. A., Yeung, K., Luker, G. D., & Ghosh, P. (2023). Growth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding. bioRxiv, (), 2022.12.02.518910. https://doi.org/10.1101/2022.12.02.518910.
  25. Vo, D., Ghosh, P., & Sahoo, D. (2022). Artificial Intelligence Guided Discovery of Gastric Cancer Continuum. bioRxiv, (), 2022.10.05.510975. https://doi.org/10.1101/2022.10.05.510975.
  26. Ghosh, P., Sinha, S., Katkar, G. D., Vo, D., Taheri, S., Dang, D., Das, S., & Sahoo, D. (2022). Machine Learning Identifies Signatures of Macrophage Reactivity and Tolerance that Predict Disease Outcomes. bioRxiv, (), 2022.06.27.497783 https://doi.org/10.1101/2022.06.27.497783.
  27. Qiao, L., Ghosh, P., & Rangamani, P. (2022). Design principles of dose-response alignment in coupled GTPase switches. bioRxiv, (), 2022.06.14.496184. https://doi.org/10.1101/2022.06.14.496184.
  28. Katkar, G. D., Anandachar, M. S., Sinha, S., Ibeawuchi, S., Espinoza, C. R., Coates, J., Malhotra, Y. S., Mullick, M., Castillo, V., Vo, D. T., Sahoo, D., & Ghosh, P. (2022). Coupling of NOD2 to GIV is Required for Bacterial Sensing. bioRxiv, (), 2022.04.26.489574 https://doi.org/10.1101/2022.04.26.489574.

2021–2022:.

  1. Elghazawy H, Bakkach J, Helal T, Aref AM, Kelany M, Abdallah LE, Abdelbakey
    FS, Ali D, Ali DZ, Ahmed MO, El-Hafeez AAA, Ghosh P, Alorabi MO. Clinico-
    pathological relationship between androgen receptor and tumour infiltrating
    lymphocytes in triple negative breast cancer. Ecancermedicalscience. 2021 Nov
    11;15:1317. doi: 10.3332/ecancer.2021.1317. PMID: 35047068; PMCID: PMC8723750.
  2. Toobian D, Ghosh P, Katkar GD. Parsing the Role of PPARs in Macrophage
    Processes. Front Immunol. 2021 Dec 22;12:783780. doi: 10.3389/fimmu.2021.783780.
    PMID: 35003101; PMCID: PMC8727354.
  3. Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo
    GW, Telese F, Ghosh P, Das S, Huang WJM. RNA binding protein DDX5 directs tuft
    cell specification and function to regulate microbial repertoire and disease
    susceptibility in the intestine. Gut. 2021 Dec 1:gutjnl-2021-324984. doi:
    10.1136/gutjnl-2021-324984. Epub ahead of print. PMID: 34853057.
  4. Vo DT, Fuller MR, Tindle C, Anandachar MS, Das S, Sahoo D, Ghosh P. SPT6 loss
    permits the transdifferentiation of keratinocytes into an intestinal fate that
    resembles Barrett's metaplasia. iScience. 2021 Sep 11;24(10):103121. doi:
    10.1016/j.isci.2021.103121. PMID: 34622168; PMCID: PMC8481972.
  5. Tindle C, Fuller M, Fonseca A, Taheri S, Ibeawuchi SR, Beutler N, Katkar GD,
    Claire A, Castillo V, Hernandez M, Russo H, Duran J, Crotty Alexander LE, Tipps
    A, Lin G, Thistlethwaite PA, Chattopadhyay R, Rogers TF, Sahoo D, Ghosh P, Das
    S. Adult stem cell-derived complete lung organoid models emulate lung disease in
    COVID-19. Elife. 2021 Aug 13;10:e66417. doi: 10.7554/eLife.66417. PMID:
    34463615; PMCID: PMC8463074.
  6. Reynoso S, Castillo V, Katkar GD, Lopez-Sanchez I, Taheri S, Espinoza C,
    Rohena C, Sahoo D, Gagneux P, Ghosh P. GIV/Girdin, a non-receptor modulator for
    Gαi/s, regulates spatiotemporal signaling during sperm capacitation and is
    required for male fertility. Elife. 2021 Aug 19;10:e69160. doi:
    10.7554/eLife.69160. PMID: 34409938; PMCID: PMC8376251.
  7. Mustafa M, Abd El-Hafeez AA, Abdelhafeez DA, Abdelhamid D, Mostafa YA, Ghosh
    P, Hayallah AM, A Abuo-Rahma GE. FAK inhibitors as promising anticancer targets:
    present and future directions. Future Med Chem. 2021 Sep;13(18):1559-1590. doi:
    10.4155/fmc-2021-0015. Epub 2021 Aug 3. PMID: 34340532; PMCID: PMC8386514.
  8. Sayed IM, Tindle C, Fonseca AG, Ghosh P, Das S. Functional assays with human
    patient-derived enteroid monolayers to assess the human gut barrier. STAR
    Protoc. 2021 Jul 17;2(3):100680. doi: 10.1016/j.xpro.2021.100680. PMID:
    34337445; PMCID: PMC8313751.
  9. Sahoo D, Swanson L, Sayed IM, Katkar GD, Ibeawuchi SR, Mittal Y, Pranadinata
    RF, Tindle C, Fuller M, Stec DL, Chang JT, Sandborn WJ, Das S, Ghosh P.
    Artificial intelligence guided discovery of a barrier-protective therapy in
    inflammatory bowel disease. Nat Commun. 2021 Jul 12;12(1):4246. doi:
    10.1038/s41467-021-24470-5. PMID: 34253728; PMCID: PMC8275683.
  10. Saul S, Karim M, Huang PT, Ghita L, Chiu W, Kumar S, Bhalla N, Leyssen P,
    Cohen CA, Huie K, Tindle C, Sibai M, Pinsky BA, Das S, Ghosh P, Dye JM, Solow-
    Cordero DE, Jin J, Jochmans D, Neyts J, Narayanan A, De Jonghe S, Einav S.
    Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication,
    inflammation, and lung injury by a drug repurposing screen. bioRxiv [Preprint].
    2021 Jun 15:2021.05.15.444128. doi: 10.1101/2021.05.15.444128. PMID: 34159337;
    PMCID: PMC8219101.

  11. A Circuit for Secretion-coupled Cellular Autonomy in Multicellular Eukaryotes
    Lingxia Qiao, Saptarshi Sinha, Amer Ali Abd El-Hafeez, I-Chung Lo, Krishna K. Midde, Tony Ngo, Nicolas Aznar, Inmaculada Lopez-Sanchez, Vijay Gupta, Marilyn G. Farquhar, Padmini Rangamani, Pradipta Ghosh
    bioRxiv 2021.03.18.436048; doi: https://doi.org/10.1101/2021.03.18.436048

  12. Regulation of DNA damage response by trimeric G-protein Signaling
    Amer Ali Abd El-Hafeez, Nina Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy, Pranavi Chamarthi, Navin Rajapakse, Soumita Das, Kathryn E. Luker, Tapas K. Hazra, Gary D. Luker, Pradipta Ghosh
    bioRxiv 2021.07.21.452842; doi: https://doi.org/10.1101/2021.07.21.452842. Accepted In Press, iScience

     

2020–2021:

  1. Elghazawy H, Bakkach J, Helal T, Aref AM, Kelany M, Abdallah LE, Abdelbakey
    FS, Ali D, Ali DZ, Ahmed MO, El-Hafeez AAA, Ghosh P, Alorabi MO. Clinico-
    pathological relationship between androgen receptor and tumour infiltrating
    lymphocytes in triple negative breast cancer. Ecancermedicalscience. 2021 Nov
    11;15:1317. doi: 10.3332/ecancer.2021.1317. PMID: 35047068; PMCID: PMC8723750.
  2. Toobian D, Ghosh P, Katkar GD. Parsing the Role of PPARs in Macrophage
    Processes. Front Immunol. 2021 Dec 22;12:783780. doi: 10.3389/fimmu.2021.783780.
    PMID: 35003101; PMCID: PMC8727354.
  3. Sayed IM, El-Hafeez AAA, Maity PP, Das S, Ghosh P. Modeling colorectal
    cancers using multidimensional organoids. Adv Cancer Res. 2021;151:345-383. doi:
    10.1016/bs.acr.2021.02.005. Epub 2021 Mar 26. PMID: 34148617; PMCID: PMC8221168.
  4. Loutfy SA, Abdallah ZF, Shaalan M, Moneer M, Karam A, Moneer MM, Sayed IM,
    Abd El-Hafeez AA, Ghosh P, Zekri AN. Prevalence of MMTV-Like <i>env</i>
    Sequences and Its Association with BRCA1/2 Genes Mutations Among Egyptian Breast
    Cancer Patients. Cancer Manag Res. 2021 Mar 26;13:2835-2848. doi:
    10.2147/CMAR.S294584. PMID: 33814932; PMCID: PMC8009344.
  5. Ear J, Abd El-Hafeez AA, Roy S, Ngo T, Rajapakse N, Choi J, Khandelwal S,
    Ghassemian M, McCaffrey L, Kufareva I, Sahoo D, Ghosh P. A long isoform of
    GIV/Girdin contains a PDZ-binding module that regulates localization and
    G-protein binding. J Biol Chem. 2021 Jan-Jun;296:100493. doi:
    10.1016/j.jbc.2021.100493. Epub 2021 Mar 3. PMID: 33675748; PMCID: PMC8042451.
  6. Shigeyasu K, Toden S, Ozawa T, Matsuyama T, Nagasaka T, Ishikawa T, Sahoo D,
    Ghosh P, Uetake H, Fujiwara T, Goel A. The PVT1 lncRNA is a novel epigenetic
    enhancer of MYC, and a promising risk-stratification biomarker in colorectal
    cancer. Mol Cancer. 2020 Nov 5;19(1):155. doi: 10.1186/s12943-020-01277-4. PMID:
    33148262; PMCID: PMC7643275.
  7. Kalogriopoulos NA, Lopez-Sanchez I, Lin C, Ngo T, Midde KK, Roy S, Aznar N,
    Murray F, Garcia-Marcos M, Kufareva I, Ghassemian M, Ghosh P. Receptor tyrosine
    kinases activate heterotrimeric G proteins via phosphorylation within the
    interdomain cleft of Gαi. Proc Natl Acad Sci U S A. 2020 Nov
    17;117(46):28763-28774. doi: 10.1073/pnas.2004699117. Epub 2020 Nov 2. PMID:
    33139573; PMCID: PMC7682395.
  8. Swanson L, Katkar GD, Tam J, Pranadinata RF, Chareddy Y, Coates J, Anandachar
    MS, Castillo V, Olson J, Nizet V, Kufareva I, Das S, Ghosh P. TLR4 signaling and
    macrophage inflammatory responses are dampened by GIV/Girdin. Proc Natl Acad Sci
    U S A. 2020 Oct 27;117(43):26895-26906. doi: 10.1073/pnas.2011667117. Epub 2020
    Oct 14. PMID: 33055214; PMCID: PMC7604444.
  9. Sayed IM, Chakraborty A, Abd El-Hafeez AA, Sharma A, Sahan AZ, Huang WJM,
    Sahoo D, Ghosh P, Hazra TK, Das S. The DNA Glycosylase NEIL2 Suppresses
    <i>Fusobacterium</i>-Infection-Induced Inflammation and DNA Damage in Colonic
    Epithelial Cells. Cells. 2020 Aug 28;9(9):1980. doi: 10.3390/cells9091980. PMID:
    32872214; PMCID: PMC7565382.
  10. Abbasi N, Long T, Li Y, Yee BA, Cho BS, Hernandez JE, Ma E, Patel PR, Sahoo
    D, Sayed IM, Varki N, Das S, Ghosh P, Yeo GW, Huang WJM. DDX5 promotes oncogene
    C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis.
    Life Sci Alliance. 2020 Aug 18;3(10):e202000772. doi: 10.26508/lsa.202000772.
    PMID: 32817263; PMCID: PMC7441524.

2019–2020:

  1. Dang D, Taheri S, Das S, Ghosh P, Prince LS, Sahoo D. Computational Approach
    to Identifying Universal Macrophage Biomarkers. Front Physiol. 2020 Apr
    8;11:275. doi: 10.3389/fphys.2020.00275. PMID: 32322218; PMCID: PMC7156600.
  2. Demb J, Yaseyyedi A, Liu L, Bustamante R, Earles A, Ghosh P, Gutkind JS,
    Gawron AJ, Kaltenbach TR, Martinez ME, Gupta S. Metformin Is Associated With
    Reduced Odds for Colorectal Cancer Among Persons With Diabetes. Clin Transl
    Gastroenterol. 2019 Nov;10(11):e00092. doi: 10.14309/ctg.0000000000000092. PMID:
    31770138; PMCID: PMC6890275.
  3. Ghosh P, Garcia-Marcos M. Do All Roads Lead to Rome in G-Protein Activation?
    Trends Biochem Sci. 2020 Mar;45(3):182-184. doi: 10.1016/j.tibs.2019.10.010.
    Epub 2019 Nov 18. PMID: 31753703; PMCID: PMC7147754.
  4. Limso C, Ngo JM, Nguyen P, Leal S, Husain A, Sahoo D, Ghosh P, Bhandari D.
    The Gα-interacting vesicle-associated protein interacts with and promotes cell
    surface localization of GRP78 during endoplasmic reticulum stress. FEBS Lett.
    2020 Mar;594(6):1088-1100. doi: 10.1002/1873-3468.13685. Epub 2019 Nov 30. PMID:
    31736058; PMCID: PMC7093220.
  5. Jansen AML, Ghosh P, Dakal TC, Slavin TP, Boland CR, Goel A. Novel candidates
    in early-onset familial colorectal cancer. Fam Cancer. 2020 Jan;19(1):1-10. doi:
    10.1007/s10689-019-00145-5. Epub 2019 Sep 25. PMID: 31555933; PMCID: PMC7241873.
  6. Saha S, Siddiqui SS, Khan N, Verhagen A, Jiang W, Springer S, Ghosh P, Varki
    A. Controversies about the subcellular localization and mechanisms of action of
    the Alzheimer's disease-protective CD33 splice variant. Acta Neuropathol. 2019
    Oct;138(4):671-672. doi: 10.1007/s00401-019-02065-1. Epub 2019 Aug 22. PMID:
    31440824.
  7. Ear J, Dunkel Y, Mittal Y, Lim BBC, Liu L, Holda MK, Nitsche U, Barbazán J,
    Goel A, Janssen KP, Aznar N, Ghosh P. Two Isoforms of the Guanine Nucleotide
    Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors. Sci Rep. 2019 Aug
    20;9(1):12124. doi: 10.1038/s41598-019-48420-w. PMID: 31431650; PMCID:
    PMC6702192.
  8. Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives
    EA, Chang G, Ghosh P, Kufareva I. Structural basis for GPCR-independent
    activation of heterotrimeric Gi proteins. Proc Natl Acad Sci U S A. 2019 Aug
    13;116(33):16394-16403. doi: 10.1073/pnas.1906658116. Epub 2019 Jul 30. Erratum
    in: Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20794. PMID: 31363053; PMCID:
    PMC6697900.
  9. Getz M, Swanson L, Sahoo D, Ghosh P, Rangamani P. A predictive computational
    model reveals that GIV/girdin serves as a tunable valve for EGFR-stimulated
    cyclic AMP signals. Mol Biol Cell. 2019 Jun 15;30(13):1621-1633. doi:
    10.1091/mbc.E18-10-0630. Epub 2019 Apr 24. PMID: 31017840; PMCID: PMC6727633.

2018–2019:

  1. Dunkel Y, Reid AL, Ear J, Aznar N, Millward M, Gray E, Pearce R, Ziman M,
    Ghosh P. Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral
    Blood of Patients with Cutaneous Melanoma. Sci Rep. 2018 Dec 21;8(1):18036. doi:
    10.1038/s41598-018-36173-x. PMID: 30575751; PMCID: PMC6303298.
  2. Midde K, Sun N, Rohena C, Joosen L, Dhillon H, Ghosh P. Single-Cell Imaging
    of Metastatic Potential of Cancer Cells. iScience. 2018 Dec 21;10:53-65. doi:
    10.1016/j.isci.2018.11.022. Epub 2018 Nov 15. PMID: 30500482; PMCID: PMC6263091.
  3. Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, Kalogriopoulos NA,
    Lopez-Sanchez I, Ghassemian M, Sahoo D, Kufareva I, Ghosh P. Convergence of Wnt,
    growth factor, and heterotrimeric G protein signals on the guanine nucleotide
    exchange factor Daple. Sci Signal. 2018 Feb 27;11(519):eaao4220. doi:
    10.1126/scisignal.aao4220. PMID: 29487190; PMCID: PMC5862031.

2017–2018:

  1. Aznar N, Sun N, Dunkel Y, Ear J, Buschman MD, Ghosh P. A Daple-Akt feed-
    forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.
    Mol Biol Cell. 2017 Dec 1;28(25):3709-3723. doi: 10.1091/mbc.E17-06-0405. Epub
    2017 Oct 11. PMID: 29021338; PMCID: PMC5706997.
  2. Siddiqui SS, Springer SA, Verhagen A, Sundaramurthy V, Alisson-Silva F, Jiang
    W, Ghosh P, Varki A. The Alzheimer's disease-protective CD33 splice variant
    mediates adaptive loss of function via diversion to an intracellular pool. J
    Biol Chem. 2017 Sep 15;292(37):15312-15320. doi: 10.1074/jbc.M117.799346. Epub
    2017 Jul 26. PMID: 28747436; PMCID: PMC5602391.
  3. Lizcano A, Secundino I, Döhrmann S, Corriden R, Rohena C, Diaz S, Ghosh P,
    Deng L, Nizet V, Varki A. Erythrocyte sialoglycoproteins engage Siglec-9 on
    neutrophils to suppress activation. Blood. 2017 Jun 8;129(23):3100-3110. doi:
    10.1182/blood-2016-11-751636. Epub 2017 Apr 17. PMID: 28416510; PMCID:
    PMC5465837.
  4. Ghosh P, Rangamani P, Kufareva I. The GAPs, GEFs, GDIs and…now, GEMs: New
    kids on the heterotrimeric G protein signaling block. Cell Cycle. 2017 Apr
    3;16(7):607-612. doi: 10.1080/15384101.2017.1282584. Epub 2017 Mar 13. PMID:
    28287365; PMCID: PMC5397260.
  5. Ghosh P. The stress polarity pathway: AMPK 'GIV'-es protection against
    metabolic insults. Aging (Albany NY). 2017 Feb 15;9(2):303-314. doi:
    10.18632/aging.101179. PMID: 28209925; PMCID: PMC5361665.

2016–2017:

  1. Ghosh P, Aznar N, Swanson L, Lo IC, Lopez-Sanchez I, Ear J, Rohena C,
    Kalogriopoulos N, Joosen L, Dunkel Y, Sun N, Nguyen P, Bhandari D. Biochemical,
    Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange
    Factor, GIV/Girdin. Curr Protoc Chem Biol. 2016 Dec 7;8(4):265-298. doi:
    10.1002/cpch.13. PMID: 27925669; PMCID: PMC5154557.
  2. Aznar N, Patel A, Rohena CC, Dunkel Y, Joosen LP, Taupin V, Kufareva I,
    Farquhar MG, Ghosh P. AMP-activated protein kinase fortifies epithelial tight
    junctions during energetic stress via its effector GIV/Girdin. Elife. 2016 Nov
    4;5:e20795. doi: 10.7554/eLife.20795. PMID: 27813479; PMCID: PMC5119889.
  3. Dunkel Y, Diao K, Aznar N, Swanson L, Liu L, Zhu W, Mi XY, Ghosh P.
    Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast
    cancers. FASEB J. 2016 Nov;30(11):3702-3713. doi: 10.1096/fj.201600500. Epub
    2016 Jul 20. PMID: 27440794; PMCID: PMC5067257.
  4. Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I,
    López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG,
    Ghosh P. GIV/Girdin activates Gαi and inhibits Gαs via the same motif. Proc Natl
    Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub
    2016 Sep 12. PMID: 27621449; PMCID: PMC5047194.
  5. Banerjee Mustafi S, Aznar N, Dwivedi SK, Chakraborty PK, Basak R, Mukherjee
    P, Ghosh P, Bhattacharya R. Mitochondrial BMI1 maintains bioenergetic
    homeostasis in cells. FASEB J. 2016 Dec;30(12):4042-4055. doi:
    10.1096/fj.201600321R. Epub 2016 Sep 9. PMID: 27613804; PMCID: PMC5102112.
  6. El Ghazal R, Yin X, Johns SC, Swanson L, Macal M, Ghosh P, Zuniga EI, Fuster
    MM. Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth.
    Neoplasia. 2016 May;18(5):294-306. doi: 10.1016/j.neo.2016.04.004. PMID:
    27237321; PMCID: PMC4887599.
  7. Ghosh P, Tie J, Muranyi A, Singh S, Brunhoeber P, Leith K, Bowermaster R,
    Liao Z, Zhu Y, LaFleur B, Tran B, Desai J, Jones I, Croxford M, Jover R, Goel A,
    Waring P, Hu S, Teichgraber V, Rohr UP, Ridder R, Shanmugam K, Gibbs P. Girdin
    (GIV) Expression as a Prognostic Marker of Recurrence in Mismatch Repair-
    Proficient Stage II Colon Cancer. Clin Cancer Res. 2016 Jul 15;22(14):3488-98.
    doi: 10.1158/1078-0432.CCR-15-2290. Epub 2016 Mar 30. PMID: 27029492; PMCID:
    PMC4947424.
  8. Barbazan J, Dunkel Y, Li H, Nitsche U, Janssen KP, Messer K, Ghosh P.
    Prognostic Impact of Modulators of G proteins in Circulating Tumor Cells from
    Patients with Metastatic Colorectal Cancer. Sci Rep. 2016 Feb 26;6:22112. doi:
    10.1038/srep22112. PMID: 26916336; PMCID: PMC4768264.
  9. Aznar N, Kalogriopoulos N, Midde KK, Ghosh P. Heterotrimeric G protein
    signaling via GIV/Girdin: Breaking the rules of engagement, space, and time.
    Bioessays. 2016 Apr;38(4):379-93. doi: 10.1002/bies.201500133. Epub 2016 Feb 16.
    PMID: 26879989; PMCID: PMC5123561.
  10. Ghosh P. The untapped potential of tyrosine-based G protein signaling.
    Pharmacol Res. 2016 Mar;105:99-107. doi: 10.1016/j.phrs.2016.01.017. Epub 2016
    Jan 22. PMID: 26808081; PMCID: PMC4775314.

2015–2016:

  1. Lopez-Sanchez I, Ma GS, Pedram S, Kalogriopoulos N, Ghosh P. GIV/girdin binds
    exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles.
    Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):287-93. doi:
    10.1016/j.bbrc.2015.10.111. Epub 2015 Oct 26. PMID: 26514725; PMCID: PMC4659757.
  2. Lopez-Sanchez I, Kalogriopoulos N, Lo IC, Kabir F, Midde KK, Wang H, Ghosh P.
    Focal adhesions are foci for tyrosine-based signal transduction via GIV/Girdin
    and G proteins. Mol Biol Cell. 2015 Dec 1;26(24):4313-24. doi:
    10.1091/mbc.E15-07-0496. Epub 2015 Oct 7. PMID: 26446841; PMCID: PMC4666128.
  3. Ma GS, Lopez-Sanchez I, Aznar N, Kalogriopoulos N, Pedram S, Midde K,
    Ciaraldi TP, Henry RR, Ghosh P. Activation of G proteins by GIV-GEF is a pivot
    point for insulin resistance and sensitivity. Mol Biol Cell. 2015 Nov
    15;26(23):4209-23. doi: 10.1091/mbc.E15-08-0553. Epub 2015 Sep 16. PMID:
    26378251; PMCID: PMC4642855.
  4. Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman
    I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. Cyclin-dependent kinase 5
    activates guanine nucleotide exchange factor GIV/Girdin to orchestrate
    migration-proliferation dichotomy. Proc Natl Acad Sci U S A. 2015 Sep
    1;112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18. PMID:
    26286990; PMCID: PMC4568279.
  5. Ghosh P. Heterotrimeric G proteins as emerging targets for network based
    therapy in cancer: End of a long futile campaign striking heads of a Hydra.
    Aging (Albany NY). 2015 Jul;7(7):469-74. doi: 10.18632/aging.100781. PMID:
    26224586; PMCID: PMC4543036.
  6. Aznar N, Midde KK, Dunkel Y, Lopez-Sanchez I, Pavlova Y, Marivin A, Barbazán
    J, Murray F, Nitsche U, Janssen KP, Willert K, Goel A, Abal M, Garcia-Marcos M,
    Ghosh P. Daple is a novel non-receptor GEF required for trimeric G protein
    activation in Wnt signaling. Elife. 2015 Jun 30;4:e07091. doi:
    10.7554/eLife.07091. PMID: 26126266; PMCID: PMC4484057.
  7. Ghosh P. G protein coupled growth factor receptor tyrosine kinase: no longer
    an oxymoron. Cell Cycle. 2015;14(16):2561-5. doi: 10.1080/15384101.2015.1066538.
    Epub 2015 Jun 30. PMID: 26126131; PMCID: PMC4613836.
  8. Ma GS, Aznar N, Kalogriopoulos N, Midde KK, Lopez-Sanchez I, Sato E, Dunkel
    Y, Gallo RL, Ghosh P. Therapeutic effects of cell-permeant peptides that
    activate G proteins downstream of growth factors. Proc Natl Acad Sci U S A. 2015
    May 19;112(20):E2602-10. doi: 10.1073/pnas.1505543112. Epub 2015 Apr 29. PMID:
    25926659; PMCID: PMC4443320.
  9. Lo IC, Gupta V, Midde KK, Taupin V, Lopez-Sanchez I, Kufareva I, Abagyan R,
    Randazzo PA, Farquhar MG, Ghosh P. Activation of Gαi at the Golgi by GIV/Girdin
    imposes finiteness in Arf1 signaling. Dev Cell. 2015 Apr 20;33(2):189-203. doi:
    10.1016/j.devcel.2015.02.009. Epub 2015 Apr 9. PMID: 25865347; PMCID:
    PMC4415880.
  10. Midde KK, Aznar N, Laederich MB, Ma GS, Kunkel MT, Newton AC, Ghosh P.
    Multimodular biosensors reveal a novel platform for activation of G proteins by
    growth factor receptors. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E937-46.
    doi: 10.1073/pnas.1420140112. Epub 2015 Feb 17. Erratum in: Proc Natl Acad Sci U
    S A. 2015 Mar 24;112(12):E1509. PMID: 25713130; PMCID: PMC4352799.

2014–2015:

  1. Ghosh P. G protein coupled growth factor receptor tyrosine kinase: no longer
    an oxymoron. Cell Cycle. 2015;14(16):2561-5. doi: 10.1080/15384101.2015.1066538.
    Epub 2015 Jun 30. PMID: 26126131; PMCID: PMC4613836.
  2. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML,
    Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Correction:
    Genome-wide mutational landscape of mucinous carcinomatosis peritonei of
    appendiceal origin. Genome Med. 2014 Jul 26;6(7):53. doi:
    10.1186/s13073-014-0053-y. PMID: 25228923; PMCID: PMC4165363.
  3. Lin C, Ear J, Midde K, Lopez-Sanchez I, Aznar N, Garcia-Marcos M, Kufareva I,
    Abagyan R, Ghosh P. Structural basis for activation of trimeric Gi proteins by
    multiple growth factor receptors via GIV/Girdin. Mol Biol Cell. 2014 Nov
    5;25(22):3654-71. doi: 10.1091/mbc.E14-05-0978. Epub 2014 Sep 3. PMID: 25187647;
    PMCID: PMC4230624.
  4. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh
    S, Shanmugam K, Aroonsakool N, Murray F, Ho SB, Seki E, Brenner DA, Ghosh P.
    GIV/Girdin is a central hub for profibrogenic signalling networks during liver
    fibrosis. Nat Commun. 2014 Jul 21;5:4451. doi: 10.1038/ncomms5451. PMID:
    25043713; PMCID: PMC4107319.
  5. Wang H, Misaki T, Taupin V, Eguchi A, Ghosh P, Farquhar MG. GIV/girdin links
    vascular endothelial growth factor signaling to Akt survival signaling in
    podocytes independent of nephrin. J Am Soc Nephrol. 2015 Feb;26(2):314-27. doi:
    10.1681/ASN.2013090985. Epub 2014 Jul 10. PMID: 25012178; PMCID: PMC4310647.
  6. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML,
    Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Genome-wide
    mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.
    Genome Med. 2014 May 29;6(5):43. doi: 10.1186/gm559. PMID: 24944587; PMCID:
    PMC4062050.

2013–2014:

  1. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML,
    Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Correction:
    Genome-wide mutational landscape of mucinous carcinomatosis peritonei of
    appendiceal origin. Genome Med. 2014 Jul 26;6(7):53. doi:
    10.1186/s13073-014-0053-y. PMID: 25228923; PMCID: PMC4165363.
  2. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML,
    Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. Genome-wide
    mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.
    Genome Med. 2014 May 29;6(5):43. doi: 10.1186/gm559. PMID: 24944587; PMCID:
    PMC4062050.
  3. Ghosh P, Cho M, Rawat G, Simkin PA, Gardner GC. Treatment of acute gouty
    arthritis in complex hospitalized patients with anakinra. Arthritis Care Res
    (Hoboken). 2013 Aug;65(8):1381-4. doi: 10.1002/acr.21989. PMID: 23650178.
  4. López-Sánchez I, Garcia-Marcos M, Mittal Y, Aznar N, Farquhar MG, Ghosh P.
    Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange
    factor, GIV/Girdin. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5510-5. doi:
    10.1073/pnas.1303392110. Epub 2013 Mar 18. PMID: 23509302; PMCID: PMC3619294.

2012–2013:

  1. Dunkel Y, Ong A, Notani D, Mittal Y, Lam M, Mi X, Ghosh P. STAT3 protein up-
    regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and
    GIV enhances STAT3 activation in a positive feedback loop during wound healing
    and tumor invasion/metastasis. J Biol Chem. 2012 Dec 7;287(50):41667-83. doi:
    10.1074/jbc.M112.390781. Epub 2012 Oct 12. PMID: 23066027; PMCID: PMC3516717.
  2. Klionsky DJ, et al.
    Guidelines for the use and interpretation of assays for monitoring autophagy.
    Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496. PMID: 22966490;
    PMCID: PMC3404883.
  3. Garcia-Marcos M, Kietrsunthorn PS, Pavlova Y, Adia MA, Ghosh P, Farquhar MG.
    Functional characterization of the guanine nucleotide exchange factor (GEF)
    motif of GIV protein reveals a threshold effect in signaling. Proc Natl Acad Sci
    U S A. 2012 Feb 7;109(6):1961-6. doi: 10.1073/pnas.1120538109. Epub 2012 Jan 25.
    PMID: 22308453; PMCID: PMC3277514.

2011–2012:

  1. Lin C, Ear J, Pavlova Y, Mittal Y, Kufareva I, Ghassemian M, Abagyan R,
    Garcia-Marcos M, Ghosh P. Tyrosine phosphorylation of the Gα-interacting protein
    GIV promotes activation of phosphoinositide 3-kinase during cell migration. Sci
    Signal. 2011 Sep 27;4(192):ra64. doi: 10.1126/scisignal.2002049. PMID: 21954290;
    PMCID: PMC4226136.
  2. Fukasawa H, Obayashi H, Schmieder S, Lee J, Ghosh P, Farquhar MG.
    Phosphorylation of podocalyxin (Ser415) Prevents RhoA and ezrin activation and
    disrupts its interaction with the actin cytoskeleton. Am J Pathol. 2011
    Nov;179(5):2254-65. doi: 10.1016/j.ajpath.2011.07.046. Epub 2011 Sep 25. PMID:
    21945805; PMCID: PMC3204015.
  3. Mittal Y, Pavlova Y, Garcia-Marcos M, Ghosh P. Src homology domain
    2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates
    G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the
    GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. J Biol Chem.
    2011 Sep 16;286(37):32404-15. doi: 10.1074/jbc.M111.275685. Epub 2011 Jul 28.
    PMID: 21799016; PMCID: PMC3173146.
  4. Garcia-Marcos M, Kietrsunthorn PS, Wang H, Ghosh P, Farquhar MG. G Protein
    binding sites on Calnuc (nucleobindin 1) and NUCB2 (nucleobindin 2) define a new
    class of G(alpha)i-regulatory motifs. J Biol Chem. 2011 Aug 12;286(32):28138-49.
    doi: 10.1074/jbc.M110.204099. Epub 2011 Jun 8. PMID: 21653697; PMCID:
    PMC3151059.
  5. Ghosh P, Garcia-Marcos M, Farquhar MG. GIV/Girdin is a rheostat that fine-
    tunes growth factor signals during tumor progression. Cell Adh Migr. 2011 May-
    Jun;5(3):237-48. doi: 10.4161/cam.5.3.15909. Epub 2011 May 1. PMID: 21546796;
    PMCID: PMC3210208.

2010–2011:

  1. Garcia-Marcos M, Jung BH, Ear J, Cabrera B, Carethers JM, Ghosh P. Expression
    of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon
    cancer. FASEB J. 2011 Feb;25(2):590-9. doi: 10.1096/fj.10-167304. Epub 2010 Oct
    25. PMID: 20974669; PMCID: PMC3023389.
  2. Lee JK, Bhargava V, Mittal RK, Ghosh P. Achalasia, alcohol-stasis, and acute
    necrotizing esophagitis: connecting the dots. Dig Dis Sci. 2011 Feb;56(2):612-4.
    doi: 10.1007/s10620-010-1297-z. Epub 2010 Jun 16. PMID: 20552400; PMCID:
    PMC3029818.
  3. Ghosh P, Beas AO, Bornheimer SJ, Garcia-Marcos M, Forry EP, Johannson C, Ear
    J, Jung BH, Cabrera B, Carethers JM, Farquhar MG. A G{alpha}i-GIV molecular
    complex binds epidermal growth factor receptor and determines whether cells
    migrate or proliferate. Mol Biol Cell. 2010 Jul 1;21(13):2338-54. doi:
    10.1091/mbc.e10-01-0028. Epub 2010 May 12. PMID: 20462955; PMCID: PMC2893996.
  4. Garcia-Marcos M, Ghosh P, Ear J, Farquhar MG. A structural determinant that
    renders G alpha(i) sensitive to activation by GIV/girdin is required to promote
    cell migration. J Biol Chem. 2010 Apr 23;285(17):12765-77. doi:
    10.1074/jbc.M109.045161. Epub 2010 Feb 15. PMID: 20157114; PMCID: PMC2857069.

2009–2010:

  1. Garcia-Marcos M, Ghosh P, Farquhar MG. GIV is a nonreceptor GEF for G alpha i
    with a unique motif that regulates Akt signaling. Proc Natl Acad Sci U S A. 2009
    Mar 3;106(9):3178-83. doi: 10.1073/pnas.0900294106. Epub 2009 Feb 11. PMID:
    19211784; PMCID: PMC2651282.

2005–2009: Residency/Fellowship Training Period (not in lab)

  1. Lee JK, Carethers JM, Ghosh P. ArterioVenous Malformation within Jejunal
    Diverticulum: an unusual cause of massive gastrointestinal bleeding.
    Gastroenterol Res Pract. 2009;2009:384506. doi: 10.1155/2009/384506. Epub 2009
    Sep 10. PMID: 19753317; PMCID: PMC2742646.
  2. Lee JK, Ghosh P, McWhorter V, Payne M, Olson R, Krinsky ML, Ramamoorthy S,
    Carethers JM. Evidence for colorectal sarcomatoid carcinoma arising from
    tubulovillous adenoma. World J Gastroenterol. 2008 Jul 21;14(27):4389-94. doi:
    10.3748/wjg.14.4389. PMID: 18666331; PMCID: PMC2731194.
  3. Ghosh P, Garcia-Marcos M, Bornheimer SJ, Farquhar MG. Activation of Galphai3
    triggers cell migration via regulation of GIV. J Cell Biol. 2008 Jul
    28;182(2):381-93. doi: 10.1083/jcb.200712066. PMID: 18663145; PMCID: PMC2483528.
  4. Lee JK, Kum J, Ghosh P. Nonmetastatic cancer of the colon associated with
    pyogenic liver abscess. Am J Gastroenterol. 2008 Mar;103(3):798-9. doi:
    10.1111/j.1572-0241.2007.01612_1.x. PMID: 18341498.
  5. Ghosh P, Olson RK, Harmon G. Sugar rush in the colon: why incidental findings
    on PET scan justify colonoscopy? Am J Gastroenterol. 2007 Nov;102(11):2609-10.
    doi: 10.1111/j.1572-0241.2007.01514_9.x. PMID: 17958772.
  6. Ghosh P, Miyai K, Chojkier M. Gastric adenocarcinoma inducing portal
    hypertension: a rare presentation. World J Gastroenterol. 2007 Feb
    14;13(6):960-3. doi: 10.3748/wjg.v13.i6.960. PMID: 17352032; PMCID: PMC4065938.
  7. Ghosh P, Kum J. Mesenteric panniculitis and sclerosing mesenteritis: a
    continuum of inflammation fibrosis. Clin Gastroenterol Hepatol. 2007
    May;5(5):A32. doi: 10.1016/j.cgh.2006.10.017. Epub 2007 Jan 29. PMID: 17261382.
  8. Ghosh P, Strong C, Naugler W, Haghighi P, Carethers JM. Peritoneal mice
    implicated in intestinal obstruction: report of a case and review of the
    literature. J Clin Gastroenterol. 2006 May-Jun;40(5):427-30. doi:
    10.1097/00004836-200605000-00012. PMID: 16721225.
  9. Ghosh P, Carethers JM. Multiple "apple-core" lesions in chronic ischemic
    colitis: the great masquerader. Am J Gastroenterol. 2009 Nov;104(11):2870-2.
    doi: 10.1038/ajg.2009.397. PMID: 19888260; PMCID: PMC6701951.
  10. Lee JK, Carethers JM, Ghosh P. ArterioVenous Malformation within Jejunal
    Diverticulum: an unusual cause of massive gastrointestinal bleeding.
    Gastroenterol Res Pract. 2009;2009:384506. doi: 10.1155/2009/384506. Epub 2009
    Sep 10. PMID: 19753317; PMCID: PMC2742646.
  11. Park FD, Lee JK, Madduri GD, Ghosh P. Generalized megaviscera of lupus:
    refractory intestinal pseudo-obstruction, ureterohydronephrosis and
    megacholedochus. World J Gastroenterol. 2009 Jul 28;15(28):3555-9. doi:
    10.3748/wjg.15.3555. PMID: 19630114; PMCID: PMC2715985.

2004–2005:

  1. Ghosh P, Kornfeld S. The GGA proteins: key players in protein sorting at the
    trans-Golgi network. Eur J Cell Biol. 2004 Jul;83(6):257-62. doi:
    10.1078/0171-9335-00374. PMID: 15511083.
  2. Ghosh P, Kornfeld S. The cytoplasmic tail of the cation-independent mannose
    6-phosphate receptor contains four binding sites for AP-1. Arch Biochem Biophys.
    2004 Jun 15;426(2):225-30. doi: 10.1016/j.abb.2004.02.011. PMID: 15158672.

2003–2004:

  1. Ghosh P, Griffith J, Geuze HJ, Kornfeld S. Mammalian GGAs act together to
    sort mannose 6-phosphate receptors. J Cell Biol. 2003 Nov 24;163(4):755-66. doi:
    10.1083/jcb.200308038. PMID: 14638859; PMCID: PMC2173681.
  2. Ghosh P, Dahms NM, Kornfeld S. Mannose 6-phosphate receptors: new twists in
    the tale. Nat Rev Mol Cell Biol. 2003 Mar;4(3):202-12. doi: 10.1038/nrm1050.
    PMID: 12612639.
  3. Ghosh P, Kornfeld S. AP-1 binding to sorting signals and release from
    clathrin-coated vesicles is regulated by phosphorylation. J Cell Biol. 2003 Mar
    3;160(5):699-708. doi: 10.1083/jcb.200211080. Epub 2003 Feb 25. PMID: 12604586;
    PMCID: PMC2173368.
  4. Ghosh P, Kornfeld S. Phosphorylation-induced conformational changes regulate
    GGAs 1 and 3 function at the trans-Golgi network. J Biol Chem. 2003 Apr
    18;278(16):14543-9. doi: 10.1074/jbc.M212543200. Epub 2003 Feb 10. PMID:
    12578827.

2002–2003:

  1. Doray B*, Ghosh P*, Griffith J, Geuze HJ, Kornfeld S. Cooperation of GGAs and
    AP-1 in packaging MPRs at the trans-Golgi network. Science. 2002 Sep
    6;297(5587):1700-3. doi: 10.1126/science.1075327. PMID: 12215646. *Co-first author.
  2. Doray B, Bruns K, Ghosh P, Kornfeld SA. Autoinhibition of the ligand-binding
    site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif. Proc
    Natl Acad Sci U S A. 2002 Jun 11;99(12):8072-7. doi: 10.1073/pnas.082235699.
    PMID: 12060753; PMCID: PMC123022.
  3. Do H, Lee WS, Ghosh P, Hollowell T, Canfield W, Kornfeld S. Human mannose
    6-phosphate-uncovering enzyme is synthesized as a proenzyme that is activated by
    the endoprotease furin. J Biol Chem. 2002 Aug 16;277(33):29737-44. doi:
    10.1074/jbc.M202369200. Epub 2002 Jun 10. PMID: 12058031.
  4. Doray B, Bruns K, Ghosh P, Kornfeld S. Interaction of the cation-dependent
    mannose 6-phosphate receptor with GGA proteins. J Biol Chem. 2002 May
    24;277(21):18477-82. doi: 10.1074/jbc.M201879200. Epub 2002 Mar 8. PMID:
    11886874.